Abstract:The aim of the present study was to investigate the effects of the anti-asthenic drug ladasten on behavioral patterns and T-cell subsets in blood, spleen, and thymus in socially stressed male C57Bl/6 mice. Mice subjected to social defeat stress (SDS) for 25 days developed a depressive-like phenotype. The submissive SDS animals were assigned to one of two treatment groups: one group was treated with ladasten (30 mg/kg, i.p.) for up to 5 days, and the other one was administered vehicle as a control. Twenty four … Show more
A number of new sulfonamide compounds with adamantane and memantine fragments were synthesized and characterized. Thermodynamic functions of sublimation processes have been determined on the basis of experimental values of saturated vapor pressures measured by the transpiration method in a wide temperature range. Thermophysical characteristics of fusion processes (melting points and fusion enthalpies) of the considered substances were studied using the DSC method. Correlation equations linking the thermodynamic characteristics of sublimation with melting points and packing densities of crystals have been proposed.
A number of sulfonamide compounds with adamantane (tricyclo[3.3.1.13,7]decane) and memantine (3,5-dimethyladamantan-1-amine) fragments have been synthesized and characterized.
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