Effects of the Modified Linggui Zhugan Decoction () Combined with Short-term Very Low Calorie Diets on Glycemic Control in Newly Diagnosed Type 2 Diabetics

Chen, Ding-sheng; Ke, Bin; Huang, Yingjuan; Meng, Jian; Zhang, Junjie; Chen, Zexiong; Michalsen, Andreas; Qin, Jian

doi:10.1016/s0254-6272(11)60038-1

Cited by 20 publications

(16 citation statements)

References 16 publications

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“…Moreover, LGZG was found to restrain the weight gain caused by antipsychotic medications without any obvious side effect [4], suggesting that LGZG may bring benefits for metabolic syndrome (MS), which is regarded as having the properties of phlegm and fluid retention in TCM. LGZG also demonstrated clinical benefits for hemorheology in hyperlipidemic rats, indicating that it might also be an alternative choice for hyperlipidemia treatment [5, 6]. Taken together, it is of great significance to explore the effect and possible mechanisms of LGZG on nonalcoholic fatty liver disease (NAFLD), the hepatic component of MS with a high prevalence.…”

Section: Introductionmentioning

confidence: 99%

Chinese Medicine Formula Lingguizhugan Decoction Improves Beta-Oxidation and Metabolism of Fatty Acid in High-Fat-Diet-Induced Rat Model of Fatty Liver Disease

Liu

Yang

Zou

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Lingguizhugan decoction (LGZG), a classic traditional Chinese medicine (TCM) formula, has been used to treat obesity and hyperlipidemia in recent years, but the related mechanisms underlying the regulation of lipid metabolism by LGZG are not clear yet. Here, we reported the effectiveness and possible mechanisms of LGZG on rats with fatty liver disease induced by high-fat diet (HFD). Our results demonstrated that LGZG significantly attenuated HFD-induced fatty liver disease, as measured by body weight, liver index, epididymal fat pad-body weight ratio (EFP/BW), liver injury, and hepatic triglycerides (TG) probably through increasing serum thyroid hormone levels, improving beta-oxidation (via modulation of TRβ1 and CPT1A expression), metabolism and transport (through modulation of SREBP-1c, ACSL and ApoB100 expression) of fatty acid. In addition, we discovered the herbal combination with the properties of warming yang to relieve water retention in the formula and proposed the biological basis of LGZG conventional effect via further study on disassembled formula. This study, for the first time, revealed the mechanisms through which LGZG regulates lipid metabolism. Furthermore, our study suggested that it might be feasible to understand the scientific implications of TCM from the perspective of classic formulas' conventional efficacy.

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Section: Introductionmentioning

confidence: 99%

Chinese Medicine Formula Lingguizhugan Decoction Improves Beta-Oxidation and Metabolism of Fatty Acid in High-Fat-Diet-Induced Rat Model of Fatty Liver Disease

Liu

Yang

Zou

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…It consists of four herbs only: Poria, Cinnamomi Ramulus, Atractylodis Macrocephalae Rhizoma, and Glycyrrhizae Radix at the weight ratio of 4 : 3 : 3 : 2 [155]. Caloric restriction therapy has been studied with metabolic disorders such as type 2 diabetes [156, 157] and obesity [158] to normalize metabolism. Recently, scientists have studied caloric restriction therapy supplemented with LGZD in Wistar rats [155].…”

Section: Studies Of Tcm Formulaementioning

confidence: 99%

A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

Sham

Chan

Wang

et al. 2014

BioMed Research International

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Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

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“…In China, a number of Chinese herbs have been shown to possess antidiabetic activities with few adverse effects (78), including Coptis chinensis, Astragalus membranaceus and Lonicera japonica (79,80); however, the mechanisms involved remain unclear. Berberine, a botanical alkaloid (Fig.…”

Section: Emerging Potential Drugs Targeting Gpr40 For the Regulation mentioning

confidence: 99%

GPR40: A therapeutic target for mediating insulin secretion

Feng

Leng

Xie

et al. 2012

International Journal of Molecular Medicine

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G-protein-coupled receptor 40 (GPR40), known as free fatty acid receptor 1, is mainly expressed in pancreatic β-cells and activated by medium- and long-chain fatty acids. Increasing evidence indicates that the activation of GPR40 in cells causes insulin secretion, and GPR40 has become an attractive therapeutic target for type 2 diabetes. Recently, certain novel GPR40 agonists have been identified that regulate glucose-stimulated insulin secretion, leading to the development of new drugs for the treatment of type 2 diabetes. In this review, we focus on progress in the physiological role of GPR40 and potential drugs targeting GPR40 over the past decade.

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Effects of the Modified Linggui Zhugan Decoction () Combined with Short-term Very Low Calorie Diets on Glycemic Control in Newly Diagnosed Type 2 Diabetics

Cited by 20 publications

References 16 publications

Chinese Medicine Formula Lingguizhugan Decoction Improves Beta-Oxidation and Metabolism of Fatty Acid in High-Fat-Diet-Induced Rat Model of Fatty Liver Disease

Chinese Medicine Formula Lingguizhugan Decoction Improves Beta-Oxidation and Metabolism of Fatty Acid in High-Fat-Diet-Induced Rat Model of Fatty Liver Disease

A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

GPR40: A therapeutic target for mediating insulin secretion

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