Effects of the melanogenic inhibitor, uracil, derived from Lactobacillus plantarum TWK10-fermented soy milk on anti-melanogenesis in B16F0 mouse melanoma cells

Chang, Chia-Jen; Dai, Ru-Yu; Leu, Yann‐Lii; Tsai, Tsung‐Yu

doi:10.1016/j.jff.2015.05.022

Cited by 18 publications

(15 citation statements)

References 55 publications

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“…They are also rich in glucoside isoflavones, such as daidzin and genistin [ 1 ]. Previous studies have shown that soymilk fermented with probiotics such as lactic acid bacteria (LAB), or its metabolites inhibit pathogen growth [ 2 ], blocks melanin production [ 3 , 4 ], suppresses serum cholesterol [ 5 , 6 ], exhibits anti-obesity effects [ 7 ] and modulates the immune system [ 2 , 8 ]. LAB-fermented soymilk also reduces the risk of atherosclerosis and related cardiovascular diseases [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Lactobacillus plantarum TWK10-Fermented Soymilk on Deoxycorticosterone Acetate-Salt-Induced Hypertension and Associated Dementia in Rats

2016

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Oxidative stress resulting from excessive production of reactive oxygen species is the major mediator of neuronal cell degeneration observed in neurodegenerative diseases, such as Alzheimer’s disease (AD) and vascular dementia (VaD). Additionally, hypertension has been shown to be a positive risk factor for VaD. Therefore, the objective of this study was to investigate the effects of Lactobacillus plantarum strain TWK10 (TWK10)-fermented soymilk on the protection of PC-12 cells in H2O2-, oxygen-glucose deprivation (OGD)- and deoxycorticosterone acetate (DOCA)-salt-induced rat models of VaD. Notably, the viabilities of H2O2-treated PC-12 cells and OGD model were significantly increased by treatment with TWK10-fermented soymilk ethanol extract (p < 0.05). In addition, oral administration of TWK10-fermented soymilk extract in DOCA-salt hypertension-induced VaD rats resulted in a significant decrease in blood pressure (p < 0.05), which was regulated by inhibiting ACE activity and promoting NO production, in addition to decreased escape latency and increased target crossing (p < 0.05). In conclusion, these results demonstrated that TWK10-fermented soymilk extract could improve learning and memory in DOCA-salt hypertension-induced VaD rats by acting as a blood pressure-lowering and neuroprotective agent.

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Section: Introductionmentioning

confidence: 99%

Effects of Lactobacillus plantarum TWK10-Fermented Soymilk on Deoxycorticosterone Acetate-Salt-Induced Hypertension and Associated Dementia in Rats

2016

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“…A previous investigation using an anti-melanogenic compound, c-phycocyanin, from spirulina, showed suppressed TYR expression through inhibition of p38 MAPK-mediated CREB activation [ 46 ]. Similarly, another study also reported the positive correlation between the suppression of p38 MAPK phosphorylation and the downregulation of MITF [ 33 ]. However, they did not clarify whether p38 directly acts on MITF phosphorylation or via CREB in this study.…”

Section: Major Pathways Involved In Melanogenesismentioning

confidence: 85%

“…In the cAMP signaling pathway, there are several critical points where skin-whitening compounds are involved in exerting their hypopigmenting effects. The major therapeutic target or regulatory points are: suppression of cAMP induction [ 30 ], inhibition of cAMP binding to PKA [ 36 , 43 ], inhibition of CREB activation and MITF downregulation [ 30 ], and inhibition of MC1R expression [ 33 ].…”

Section: Major Pathways Involved In Melanogenesismentioning

confidence: 99%

Hypopigmenting Effects of Brown Algae-Derived Phytochemicals: A Review on Molecular Mechanisms

et al. 2017

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There is a rapid increase in the demand for natural hypopigmenting agents from marine sources for cosmeceutical and pharmaceutical applications. Currently, marine macroalgae are considered as a safe and effective source of diverse bioactive compounds. Many research groups are exploring marine macroalgae to discover and characterize novel compounds for cosmeceutical, nutraceutical, and pharmaceutical applications. Many types of bioactive secondary metabolites from marine algae, including phlorotannins, sulfated polysaccharides, carotenoids, and meroterpenoids, have already been documented for their potential applications in the pharmaceutical industry. Among these metabolites, phlorotannins from brown algae have been widely screened for their pharmaceutical and hypopigmenting effects. Unfortunately, the majority of these articles did not have detailed investigations on molecular targets, which is critical to fulfilling the criteria for their cosmeceutical and pharmaceutical use. Very recently, a few meroterpenoids have been discovered from Sargassum sp., with the examination of their anti-melanogenic properties and mechanisms. Despite the scarcity of in vivo and clinical investigations of molecular mechanistic events of marine algae-derived hypopigmenting agents, identifying the therapeutic targets and their validation in humans has been a major challenge for future studies. In this review, we focused on available data representing molecular mechanisms underlying hypopigmenting properties of potential marine brown alga-derived compounds.

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“…Uracil (9) in particular was previously evidenced to block the expression of melanin synthesis related genes. [37] The above results seemed to indicate that compounds 4, 7, 1, 3, 11, 6 and 9 could be lead natural compounds for development of new antimelanogenic drugs with improved safety margin, since they selectively suppressed melanin production with no effect on cell viability. Also their IC 50 values were lower than arbutin, the positive control.…”

Section: Antimelanogenic Activitymentioning

confidence: 87%

“…Compound 8 was not further investigated due to limited amount. Apart from compounds 3 [14] and 9, [37] the antimelanogenic activity of the tested compounds is described for the first time. In terms of IC 50 values, compounds 4, 7 and 1 were the most active, IC 50 = 30.8 � 5.75, 38.5 � Notably, the tested compounds were found to be more potent inhibitors of melanin production than arbutin, the positive control, IC 50 = 151.7 � 1.27.…”

Section: Antimelanogenic Activitymentioning

confidence: 99%

Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami

Elsbaey

Sallam

El-Metwally

et al. 2019

Chemistry & Biodiversity

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Two new compounds, named 3,4‐dimethoxyphenyl α‐d‐ribofuranoside (1) and 3β‐(β‐d‐glucopyranosyloxy)olean‐12‐ene‐23,28,30‐trioic acid (2), together with thirteen known compounds, were isolated from the white beans culture of the marine derived endophytic fungus Aspergillus amstelodami. Structure elucidation of the new compounds was carried out by one‐, two‐dimensional spectroscopy, and high resolution electrospray ionization mass. The antimelanogenic and anti‐allergic activity of the isolated compounds were investigated. Compounds 4, 7, 1, 3, 11, 6 and 9 selectively suppressed melanin production in B16 melanoma cells, using arbutin as a positive control. Their IC50 values were 30.8±5.57, 38.5±6.08, 52.6±6.64, 98.0±1.16, 100.4±3.05, 112.0±0.22 and 144.7±2.35 μm, respectively, while that of arbutin was 151.7±1.27 μm. The tested compounds did not show any significant anti‐allergic activity in RBL‐2H3 cells, as compared to quercetin.

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Effects of the melanogenic inhibitor, uracil, derived from Lactobacillus plantarum TWK10-fermented soy milk on anti-melanogenesis in B16F0 mouse melanoma cells

Cited by 18 publications

References 55 publications

Effects of Lactobacillus plantarum TWK10-Fermented Soymilk on Deoxycorticosterone Acetate-Salt-Induced Hypertension and Associated Dementia in Rats

Effects of Lactobacillus plantarum TWK10-Fermented Soymilk on Deoxycorticosterone Acetate-Salt-Induced Hypertension and Associated Dementia in Rats

Hypopigmenting Effects of Brown Algae-Derived Phytochemicals: A Review on Molecular Mechanisms

Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami

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