Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on plasma omentin-1 levels in patients with type 2 diabetes mellitus

Cardioprotective Properties of Omentin-1 in Type 2 Diabetes: Evidence from Clinical and In Vitro Studies

“…We observed a weak tendency of omentin-1 levels associating with aorta distensibility, but not with pulse wave velocity. Other studies reported increases in omentin-1 levels following a 6–month metformin intervention in women with the polycystic ovary syndrome [30], and following treatment of Chinese patients with DM2 with poor glycemic control with metformin combined with liraglutide [31]. Although metformin improved glycemic control [22], we observed no effect of metformin on omentin-1 levels in our study population containing men with well-controlled DM2.…”

“…Although metformin improved glycemic control [22], we observed no effect of metformin on omentin-1 levels in our study population containing men with well-controlled DM2. It remains to be clarified whether this can be ascribed to differences among the study cohorts, such as gender, glycemic control, disease status, ethnicity, and the lack of a ‘metformin only’ group in the Chinese study [31].…”

“…In this respect, the clinical studies that addressed this issue reported no impact of gender on circulating omentin-1 levels [35]–[38]. However, one should note that others reported conflicting data with elevated levels found in both men and women as compared to the other gender [8], [12], and sometimes dependent on disease status [31]. Furthermore, it is unclear how omentin-1 synthesis is regulated in response to external stimuli.…”

Synovial Fluid Omentin-1 Levels are Inversely Correlated with Radiographic Severity of Knee Osteoarthritis

“…6 Omentin is codified by 2 genes, omentin-1 and omentin-2, and the former is the major circulating form in human extracellular fluid. 7 It has been reported that omentin was present in synovial fluid (SF) of patients with rheumatoid arthritis (RA) and OA, suggesting it may be implicated in the pathophysiological process of OA. 8 However, there have been no such studies clarifying the relationship between serum and SF levels of omentin-1 and disease severity of primary knee OA.…”

Comparative effectiveness of diet alone and diet plus metformin treatment on omentin levels in type 2 diabetes patients with nonalcoholic fatty liver disease: a prospective randomized trial

“…Other studies demonstrated that metformin treatment decreased omentin levels in diabetes and polycystic ovary syndrome (28,29). However, Esteghamati et al found that both insulin sensitizers -metformin and pioglitazone-are decresed serum omentin concentrations in diabetic patients (30).…”