Synovial Fluid Omentin-1 Levels are Inversely Correlated with Radiographic Severity of Knee Osteoarthritis

Xu, Lin; Zhu, Guozhong; Wang, Þ Lei; Dan-feng, Wang; Jiang, Xiaorui

doi:10.2310/jim.0b013e31824443cb

Cited by 36 publications

(28 citation statements)

References 21 publications

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“…Stwierdzono zmniejszone stężenie tego białka u pacjentów z aktywną chorobą Leśniowskiego-Crohna, które w większym stopniu korelowało z nasileniem choroby zapalnej jelit niż stę-żenie białka C-reaktywnego. Dlatego też oznaczanie What is more, low omentin concentrations have been detected in the synovial fluid in patients with osteoarthritis, which points to the usefulness of omentin as a biomarker for determining the stage of the degenerative process [18].…”

Section: Omentynaunclassified

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Role of omentin and vaspin in metabolic diseases in association with psoriasis

Kiluk¹,

Baran²,

Flisiak³

2017

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Psoriasis is a chronic skin disease characterized by systemic inflammation associated with an increased risk of metabolic and cardiovascular complications. A special role in maintaining systemic inflammation is attributed to obesity. Adipose tissue is an active endocrine organ which, through adipokine secretion, is involved in the regulation of many systemic metabolic pathways. Obesity increases the risk of developing type 2 diabetes mellitus, atherosclerosis, cardiovascular diseases and hypertension. The paper presents the characteristics of two relatively recently discovered and little known adipokines: omentin and vaspin. They are considered to have beneficial effects preventing the development of metabolic disorders associated with obesity. In addition, attention was given to their possible involvement in the pathogenesis of psoriasis and potential use as markers of disease severity and the risk of developing metabolic complications. stReszczenIe Łuszczyca jest przewlekłą chorobą skóry, w której ogólnoustrojowy stan zapalny wiąże się ze zwiększonym ryzykiem rozwoju powikłań metabolicznych i sercowo-naczyniowych. Szczególne znaczenie w podtrzymaniu stanu zapalnego w organizmie ma otyłość. Tkanka tłuszczo-wa jest aktywnym organem endokrynnym, który poprzez wydzielane adipokiny bierze udział w regulacji licznych szlaków metabolicznych ustroju. Otyłość zwiększa ryzyko rozwoju cukrzycy typu 2, miażdżycy, chorób sercowo-naczyniowych oraz nadciśnienia. W pracy przedstawiono charakterystykę stosunkowo nowo odkrytych i mało poznanych adipokin: omentyny i waspiny, którym przypisuje się korzystne działanie, chroniące przed rozwojem zaburzeń metabolicznych towarzyszących otyłości. Ponadto zwrócono uwagę na ich potencjalny udział w patogenezie łuszczycy oraz możliwość wykorzystania jako markerów nasilenia choroby oraz ryzyka rozwoju powikłań metabolicznych.

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Section: Omentynaunclassified

“…Ponadto małe stężenie omentyny stwierdzono w płynie maziowym pacjentów z chorobą zwyrodnieniową stawów, co sugeruje znaczenie tej substancji jako biomarkera zaawansowania procesu zwyrodnienia [18].…”

Section: Omentynaunclassified

Role of omentin and vaspin in metabolic diseases in association with psoriasis

Kiluk¹,

Baran²,

Flisiak³

2017

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“…The studies by Duan et al, 24 , Hao et al, 25 and Xu et al, 26 suggest that adipokines are involved in various forms of OA whereas the study by van Spil and co-workers 14 suggests that adipokines are not involved in cartilage metabolism. Clearly, this is an active area of research and further studies are required to explain the differing outcomes of these studies.…”

Section: Introductionmentioning

confidence: 96%

“…Therefore, this adipokine has the capacity of modulating glucose metabolism and insulin signaling. Xu et al, 26 used ELISAs to measure omentin-1 levels in serum and synovial fluid of patients with knee OA and correlated the values with radiographic disease severity using the KellgreneLawrence (KL) grading system. There were no significant differences in serum omentin-1 levels between patients with OA and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Osteoarthritis year 2012 in review: biomarkers

Mobasheri

2012

Osteoarthritis and Cartilage

106

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Novel OA biomarkers are needed for sub-clinical disease diagnosis. Proteomic techniques are beginning to yield useful data and deliver new OA biomarkers in serum and urine. Combining biochemical markers with tissue and cell imaging techniques and bioinformatics (i.e., machine learning, clustering, data visualization) may facilitate the development of biomarker combinations enabling earlier detection of OA.

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“…3 All joints may be affected, but the knee is the most clinically significant site of primary OA involvement. 4 The causes of disease onset and individual variation in susceptibility and progression remain elusive. A suite of OA risk factors has been identified, including genetic variation, age, sex, obesity, reproductive status (e.g., postmenopausal) in females, mechanical stresses, leg muscle strength, and related parameters, and history of previous joint trauma.…”

Section: Introductionmentioning

confidence: 99%