Effects of the intake of &lt;i&gt;Undaria pinnatifida &lt;/i&gt;(Wakame) and its &lt;i&gt;sporophylls &lt;/i&gt;(Mekabu) on postprandial glucose and insulin metabolism

Tanemura, Yoko; Yamanaka-Okumura, Hisami; Sakuma, Masae; Nii, Yoshitaka; Taketani, Yutaka; Takeda, Eiji

doi:10.2152/jmi.61.291

Cited by 31 publications

(38 citation statements)

References 26 publications

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“…cocoa and grapes, increase cerebral blood flow. Tanemura et al (2014) examined the postprandial blood glucose profiles of 12 healthy adults (eight men, four women, average age 25) after a meal with and without the inclusion of fresh, cooked, whole U. pinnatifida (wakame), or sporophylls of U. pinnatifida (mekabu). An average Japanese cooked breakfast of white rice (200 g), boiled soya beans, broccoli, and potatoes was supplemented with either 70 g fresh wakame or 70 g fresh mekabu.…”

Section: Type 2 Diabetesmentioning

confidence: 99%

“…The small mekabu shoots that grow from the parent wakame seaweed thallus are more viscous when cooked. This is due to their higher content of soluble viscous fibre, which affects carbohydrate metabolism and delays gastric emptying (Tanemura et al 2014). It was concluded that the addition of fresh, brown seaweed to meals could be useful in controlling blood glucose levels for people with type 2 diabetes.…”

Section: Type 2 Diabetesmentioning

confidence: 99%

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Seaweeds as nutraceuticals for health and nutrition

2019

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Throughout human history, seaweeds have been used as food, folk remedies, dyes, and mineral-rich fertilisers. Seaweeds as nutraceuticals or functional foods with dietary benefits beyond their fundamental macronutrient content, are now a major research and industrial development concept. The occurrence of dietary and lifestyle-related diseases, notably type 2 diabetes, obesity, cancer, and metabolic syndrome has become a health epidemic in developed countries. Global epidemiological studies have shown that countries where seaweed is consumed on a regular basis have significantly fewer instances of obesity and dietary-related disease. This review outlines recent developments in seaweed applications for human health from an epidemiological perspective and as a functional food ingredient.

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Section: Type 2 Diabetesmentioning

confidence: 99%

Section: Type 2 Diabetesmentioning

confidence: 99%

Seaweeds as nutraceuticals for health and nutrition

2019

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“…The consumption of commercial blend of Ascophyllum nodosum and Fucus vesiculosus was associated with improved insulin regulation and sensitivity, measured in human subjects using the Cederholm index upon carbohydrate ingestion, compared with placebo [ 45 ]. Consumption of mekabu (sporophylls of Undaria pinnatifida ) with a white rice-based breakfast by healthy volunteers demonstrated a reduction of post-prandial glucose concentration and this was attributed to the content and viscosity of fucoxanthin in mekabu [ 46 ]. Recently, a study involving more than 4000 participants in Korea revealed that insulin level and insulin resistance were inversely associated with dietary intake of flavonols and flavones, thereby reducing the risk of T2DM [ 47 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Bioactive Compounds from Seaweed for Diabetes Management

et al. 2015

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Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the search for new preventive and treatment strategies. Improved comprehension of T2DM pathophysiology provided various new agents and approaches against T2DM including via nutritional and lifestyle interventions. Seaweeds are rich in dietary fibres, unsaturated fatty acids, and polyphenolic compounds. Many of these seaweed compositions have been reported to be beneficial to human health including in managing diabetes. In this review, we discussed the diversity of seaweed composition and bioactive compounds which are potentially useful in preventing or managing T2DM by targeting various pharmacologically relevant routes including inhibition of enzymes such as α-glucosidase, α-amylase, lipase, aldose reductase, protein tyrosine phosphatase 1B (PTP1B) and dipeptidyl-peptidase-4 (DPP-4). Other mechanisms of action identified, such as anti-inflammatory, induction of hepatic antioxidant enzymes’ activities, stimulation of glucose transport and incretin hormones release, as well as β-cell cytoprotection, were also discussed by taking into consideration numerous in vitro, in vivo, and human studies involving seaweed and seaweed-derived agents.

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“…Another study investigated the enrichment of a test meal enriched with Wakame and Mekabu, two nutritionally identical preparations obtained from U. pinnatifida characterized by different viscosities. The Mekabu meal significantly reduced the postprandial blood glucose levels (30 min) and glucose AUC, modifying the high glycaemic index of white rice, thus confirming the usefulness of this brown seaweed in controlling T2DM [ 177 ].…”

Section: Clinical Studies Investigating Brown Seaweeds For Ms Treamentioning

confidence: 89%

Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

Gabbia

Martin

2020

Molecules

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Metabolic syndrome is characterized by the coexistence of different metabolic disorders which increase the risk of developing type 2 diabetes mellitus and cardiovascular diseases. Therefore, metabolic syndrome leads to a reduction in patients’ quality of life as well as to an increase in morbidity and mortality. In the last few decades, it has been demonstrated that seaweeds exert multiple beneficial effects by virtue of their micro- and macronutrient content, which could help in the management of cardiovascular and metabolic diseases. This review aims to provide an updated overview on the potential of brown seaweeds for the prevention and management of metabolic syndrome and its associated diseases, based on the most recent evidence obtained from in vitro and in vivo preclinical and clinical studies. Owing to their great potential for health benefits, brown seaweeds are successfully used in some nutraceuticals and functional foods for treating metabolic syndrome comorbidities. However, some issues still need to be tackled and deepened to improve the knowledge of their ADME/Tox profile in humans, in particular by finding validated indexes of their absorption and obtaining reliable information on their efficacy and long-term safety.

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Effects of the intake of <i>Undaria pinnatifida </i>(Wakame) and its <i>sporophylls </i>(Mekabu) on postprandial glucose and insulin metabolism

Cited by 31 publications

References 26 publications

Seaweeds as nutraceuticals for health and nutrition

Seaweeds as nutraceuticals for health and nutrition

Potential Bioactive Compounds from Seaweed for Diabetes Management

Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases

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