Effects of the Hyptis martiusii Benth. leaf essential oil and 1,8-cineole (eucalyptol) on the central nervous system of mice

Traditional remedies have been used for thousand years for the prevention and treatment of infectious diseases, particularly in developing countries. Of growing interest, the plant Artemisia annua, known for its malarial properties, has been studied for its numerous biological activities including metabolic, anti-tumor, anti-microbial and immunomodulatory properties. Artemisia annua is very rich in secondary metabolites such as monoterpenes, sesquiterpenes and phenolic compounds, of which the biological properties have been extensively studied. The purpose of this review is to gather and describe the data concerning the main chemical components produced by Artemisia annua and to describe the state of the art about the biological activities reported for this plant and its compounds beyond malaria.

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“…Insecticidal, expectorant, anti-inflammatory, antibacterial, antifungal, antitumor [43][44][45][46][47][48][49] Table 1. Cont.…”

Section: 8-cineolementioning

confidence: 99%

Artemisia annua, a Traditional Plant Brought to Light

Septembre-Malaterre

Rakoto

Marodon³

et al. 2020

IJMS

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“…Sleep regulatory activity was also determined for 1,8-cineole by way of experiments utilizing sodium pentobarbital- or ethyl ether-induced assays based on female Swiss mice treated with 50 mg/kg i.p. of the monoterpene [ 203 ]). Detailed results analyses of both tests bring to light the positive influence of eucalyptol ( w ) on increasing sleep time.…”

Section: Insomniamentioning

confidence: 99%

Activity of Selected Group of Monoterpenes in Alzheimer’s Disease Symptoms in Experimental Model Studies—A Non-Systematic Review

Wojtunik-Kulesza

Rudkowska

Kasprzak-Drozd

et al. 2021

IJMS

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Alzheimer’s disease (AD) is the leading cause of dementia and cognitive function impairment. The multi-faced character of AD requires new drug solutions based on substances that incorporate a wide range of activities. Antioxidants, AChE/BChE inhibitors, BACE1, or anti-amyloid platelet aggregation substances are most desirable because they improve cognition with minimal side effects. Plant secondary metabolites, used in traditional medicine and pharmacy, are promising. Among these are the monoterpenes—low-molecular compounds with anti-inflammatory, antioxidant, enzyme inhibitory, analgesic, sedative, as well as other biological properties. The presented review focuses on the pathophysiology of AD and a selected group of anti-neurodegenerative monoterpenes and monoterpenoids for which possible mechanisms of action have been explained. The main body of the article focuses on monoterpenes that have shown improved memory and learning, anxiolytic and sleep-regulating effects as determined by in vitro and in silico tests—followed by validation in in vivo models.

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“…In this context, it is observed that foods rich in bioactive compounds could be a safer therapeutic alternative and in some cases more effective in preventing or treating anxiety and pain (SILVA et al, 2020;DHAWAN et al, 2001;NASCIMENTO-SILVA, 2019). In particular, essential oils and their chemical components have shown promising results in studies using animal models of anxiety and pain that reinforce the great neuro-pharmacological potential of these natural products (DOBETSBERGER;BUCHBAUER, 2011;LA ROCCA et al, 2017;SOBREIRA et al, 2019).…”

Section: Introductionmentioning

confidence: 97%