Anxiolytic and antinociceptive-like effects of cinnamic alcohol by possible GABAergic pathway modulation: In vivo and in silico studies

Andrade, Humberto Hugo Nunes de; Monteiro, Álefe Brito; Braga, Renan Marinho; Cruz, Ryldene Marques Duarte da; Salvadori, Mirian Graciela da Silva Stiebbe; Scotti, Marcus Tullius; Sousa, Damião Pergentino de; Almeida, Reinaldo Nóbrega de

doi:10.34117/bjdv6n7-690

Cited by 6 publications

(3 citation statements)

References 36 publications

(38 reference statements)

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“…Moreover, cinnamic alcohols (a phenylpropanoid of cinnamon)-treated animals (6.25, 12.5, 25 mg/kg) exhibited reduced paw licking behavior in the first and second phases of the formalin test. Cinnamic alcohol’s anxiolytic and antinociceptive-like effects were suggested to be due to GABAergic system modulation [ 61 ]. The clove-NG inhibited the rat’s paw licking time in the late phase.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Esmaeili

Zahmatkeshan

Yousefpoor

et al. 2022

BMC Complement Med Ther

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Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Esmaeili

Zahmatkeshan

Yousefpoor

et al. 2022

BMC Complement Med Ther

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“…The first phase (neurogenic) begins immediately after the intraplantar injection of formalin and is associated with the stimulation of nociceptors (usually C fibers) by glutamate, histamine, substance P, and nitric oxide. The second phase, related to local inflammation, is more continual and durable and involves the release of pro-inflammatory agents (TNF-α, interleukins, bradykinin, prostaglandins, and serotonin) ( Hunskaar and Hole, 1987 ; Silva et al, 2017 ; Andrade et al, 2020 ). In general, analgesic agents with central action inhibit both phases of the formalin test, such as opioid analgesics, while peripheral analgesic drugs suppress only the second phase ( Aragão Neto et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice

Mangueira

Sousa²,

Batista³

et al. 2022

Front. Pharmacol.

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Acridine derivatives have been found with anticancer and antinociceptive activities. Herein, we aimed to evaluate the toxicological, antitumor, and antinociceptive actions of N’-(6-chloro-2-methoxyacridin-9-yl)-2-cyanoacetohydrazide (ACS-AZ), a 9-aminoacridine derivative with antimalarial activity. The toxicity was assessed by acute toxicity and micronucleus tests in mice. The in vivo antitumor effect of ACS-AZ (12.5, 25, or 50 mg/kg, intraperitoneally, i.p.) was determined using the Ehrlich tumor model, and toxicity. The antinociceptive efficacy of the compound (50 mg/kg, i.p.) was investigated using formalin and hot plate assays in mice. The role of the opioid system was also investigated. In the acute toxicity test, the LD50 (lethal dose 50%) value was 500 mg/kg (i.p.), and no detectable genotoxic effect was observed. After a 7-day treatment, ACS-AZ significantly (p < 0.05) reduced tumor cell viability and peritumoral microvessels density, suggesting antiangiogenic action. In addition, ACS-AZ reduced (p < 0.05) IL-1β and CCL-2 levels, which may be related to the antiangiogenic effect, while increasing (p < 0.05) TNF-α and IL-4 levels, which are related to its direct cytotoxicity. ACS-AZ also decreased (p < 0.05) oxidative stress and nitric oxide (NO) levels, both of which are crucial mediators in cancer known for their angiogenic action. Moreover, weak toxicological effects were recorded after a 7-day treatment (biochemical, hematological, and histological parameters). Concerning antinociceptive activity, ACS-AZ was effective on hotplate and formalin (early and late phases) tests (p < 0.05), characteristic of analgesic agents with central action. Through pretreatment with the non-selective (naloxone) and μ1-selective (naloxonazine) opioid antagonists, we observed that the antinociceptive effect of ACS-AZ is mediated mainly by μ1-opioid receptors (p < 0.05). In conclusion, ACS-AZ has low toxicity and antitumoral activity related to cytotoxic and antiangiogenic actions that involve the modulation of reactive oxygen species, NO, and cytokine levels, in addition to antinociceptive properties involving the opioid system.

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“…These behavioral conditions directly interfere in the management of asthma and have been associated with low adherence to treatment and increased morbidity and mortality [37]. In search of a better understanding of the mechanisms involved in the anxiety-like response, EPM test has been widely used as one of the main murine models in the search for new anxiolytic drugs as the well-established benzodiazepines [38].…”

Section: Effect Of Warifteine Treatment On Leukocyte Recruitment To Balfmentioning

confidence: 99%

Warifteine Therapeutic Treatment Reduced Leukocyte Recruitment and Anxiety-Like Response in Ovalbumin-Induced Allergic Pulmonary Inflammation / Tratamento Terapêutico Com Warifteína Reduz Recrutamento De Leucócitos E Resposta Semelhante Á Ansiedade Na Inflamação Pulmonar Alérgica Induzida Por Ovalbumina

Sousa

Ferreira

Neto

et al. 2020

BJD

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Anxiolytic and antinociceptive-like effects of cinnamic alcohol by possible GABAergic pathway modulation: In vivo and in silico studies

Abstract: Anxiolytic and antinociceptive-like effects of cinnamic alcohol by possible GABAergic pathway modulation: In vivo and in silico studies Efeitos ansiolítico e antinociceptivo do álcool cinâmico por possível modulação da via GABAérgica: Estudos in vivo e in sílico

Cited by 6 publications

References 36 publications

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice

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