Effects of the herbicide Roundup™ on the ultrastructural pattern of hepatocytes in carp (Cyprinus carpio)

Acute toxicity and histopathological alterations of Roundup® herbicide on "cachama blanca" (Piaractus brachypomus)

“…Moreover, in T 2 eosinophilic reticular material began to appear in the cytoplasm of the hepatocytes and increased with increasing Roundup ® concentrations, generating cytoplasmatic hyaline droplets in T 5 (Fig.6). These hyaline droplets have been described by Szarek et al (2000) and by Jiraungkoorskul et al (2003) in others fishes exposed to Roundup ® . The hyaline droplets may represent alterations in the protein metabolism and synthesis (Papadimitriou et al 2000, Jiraungkoorskul et al 2003 due to failures in the transcription process caused by Roundup ® (Marc et al 2005).…”

“…Previous studies have determined that the toxicity of Roundup ® in fishes is given by the POEA and that its toxicity is affected by physical-chemical water parameters, such as pH, temperature and hardness (Folmar et al 1979), as well as by the fish species with a LC 50 (lethal concentration 50) for the Roundup ® in teleosts ranging from 2.3 to 54.8mg L -1 (Folmar et al 1979, Hildebrand et al 1982, Jiraungkoorskul et al 2002. Several authors have reported the development of necrotic and proliferative lesions, aneurysms and leukocyte infiltration in the gills (Neškovic et al 1996, Jiraungkoorskul et al 2002, as well as degenerative changes, lipidic vacuolization and hyaline droplets in hepatocytes (Szarek et al 2000, Jiraungkoorskul et al 2003) in fishes exposed to commercial formulations of GP.…”

Assessment of the health status of wild fish inhabiting a cotton basin heavily impacted by pesticides in Benin (West Africa)

“…Similar lesions were observed in African catfish sampled from polluted rivers in South Africa by Van Dyk et al (2012). Several investigators reported degenerative changes, lipid vacuolization, and hyaline droplets in hepatocytes of fish exposed to commercial formulations of glyphosate (Szarek et al, 2000;Jiraungkoorskul et al, 2002Jiraungkoorskul et al, , 2003Langiano and Martinez, 2008;Albinati et al, 2007 and). In Nigeria, Olarinmoye et al (2011) described hydropic degeneration, hepatic necrosis, hemosiderosis and the foci of cell alterations in the liver of brackish water catfish, Chrysitchtys nigrodigitatus that were exposed to organochlorine pesticides.…”

Bioaccumulation and ultrastructural alterations of gill and liver in Asian sea bass,Lates calcarifer(Bloch) in sublethal copper exposure

“…The result of this study was similar to that of Subhadra (1982, 1985) who studied on the chronic effects of Cd (0.2 mg L −1 ) in cat fish H. fossilis and found that after 60 days of exposure, liver glycogen increased which was related to the decreased activity of lactate dehydrogenases, pyruvate dehydrogenases and succinate dehydrogenase in the liver. A wide spectrum of RER modifications, appearance of myelinoid bodies, deformation of mitochondria and the nuclear envelope are also herbicide induced alterations in hepatocytes of rainbow trout, O. mykiss, and carp, C. carpio, as reported respectively by Braunbeck et al (1992) and Szarek et al (2000). According to Franchini et al (1991), the increase in heterochromatin in the nuclei, in addition to the pathological changes within RER, suggests impairment to the synthetic and secretory activities of the cell.…”