Effects of the GnRH analogue deslorelin implants on reproduction in female domestic cats

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats

“…Although LH release was not monitored in this study, it is well documented that GnRH administration does cause suppression of LH in almost all the species including dogs [25] and [26]. It is, therefore, a possibility that the decreased levels of estradiol observed in the implanted cats may be the result of suppressed gonadotropins in these animals [3]. In this study, LH suppression by deslorelin implantation seems to be quite effective and consistent, and might have resulted in the lower expression of LHR mRNA observed in the implanted cats.…”

“…Previous studies in female cats have shown the ability of GnRH-agonists to suppress their reproductive tract and/or function, but an upregulation/flare-up effect was reported during the early stages of the treatment that resulted into exhibition of estrus symptoms which is undesirable [1] and [3]. However, such an upregulation effect was not observed with the implantation of GnRH-agonist in the prepubertal female dogs [4].…”

“…Estrus behavior (rubbing and rolling, lordosis, tail deflection, treading of the hind limbs, vocalization, and the acceptance of mating with intact males) of all the cats was monitored as described previously [2] and [3] throughout the experimental period of 48 weeks. Estrus detection was confirmed by vaginal cytological pattern consisting of a clear background with more than 80% of superficial cells [9] and/or serum estradiol concentrations more than 20 pg/mL [2] and [6] or 42.2 to 157.8 pmol/L [10].…”

“…Nonsurgical contraception in the female cat is thought to be potentially a challenge, considering the unique pattern of estrous cycle in this species [2]. However, GnRH-agonists can be used for the purpose of contraception in mammals at a wide range of age and at different stages of estrous cycles [1], [3], [4], [5], [6] and [7]. Although the use of GnRH-agonist for the control of cat population may still be too expensive, cat breeders might consider it as an option to control estrus in breeding queens.…”

Di̇şi̇ Köpek Ve Kedi̇lerde Üremeni̇n Kontrolünde GNRH Agoni̇stleri̇

“…Kedilerde deslorelinin implant uygulamalarından sonra fertilitenin tekrar eski haline döndüğü kızgınlıkların doğal olarak meydana geldiği ve normal sayıda yavru yaptıkları bildirilmektedir (10,12).…”