Effects of the cimetidine on the biliary excretion of rosebengal in rats

Abstract

Effect of the cimetidine on the biliary excretion of Rosebengal (RBG) was determined in rat after treatment with two different doses of cimetidine 80 mg/kg and/or 10mg/kg in aqueous solution administered intraperitoneally. Rosebengal (4mg/kg) was administered i.p. After treatment the excretion pattern of the effect of cimetidine on bile flow, plasma and liver were studied. The study showed that cimetidine at 80mg/kg increased the plasma concentration of RBG excreted up to 45min after administration while bile flow continued to increase even after 120 mini of treatment. At both concentrations of cimetidine there was a tendency in the direction of an increase in bile flew, plasma, liver weight and RBG liver concentrations, while there was decrease in RBG biliary excretion and RBG bile concentration. The excretion of RBG from hepatic cells in bile suggests that cimetidine has negative effect on the liver cells.