“…9 ( 78 ‒ 81 )], were effective against SARS-CoV-2 infection with IC 50 s of 0.023, 0.22, 0.19, 0.3 and 0.41 μmol/L, respectively, in Vero E6 cells ( Table 3 ). As reported, MDL-28170, a cathepsin B inhibitor, could impairs infection by SARS-CoV and Ebola virus 192 , 193 , ONO 5334 is a cathepsin K inhibitor 194 , and VBY-825 acts as a reversible cathepsin protease inhibitor 195 . Apilimod, a specific PIKfyve kinase inhibitor, was shown to be effective in inhibiting virus entry, which is in agreement with the report that PIKfyve is predominately presented in early endosomes and plays an important role in maintaining endomembrane homeostasis 196 .…”