Effects of the Autologous Platelet-Rich Plasma in Nasal Pack on Postoperative Quality of Life

Kuzucu, İhsan; Beriat, Güçlü Kaan; Ezerarslan, Hande; Özdemir, Sedat; Kocatürk, Sinan

doi:10.1097/scs.0000000000003664

Cited by 12 publications

(8 citation statements)

References 9 publications

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“…Platelet-rich plasma (PRP) contains a high number of platelets, growth factors (GF), and bioactive and neurotropic agents, crucial for wound healing and tissue repair. PRP has been used in various medical realms, such as orthopedic surgery, maxillofacial interventions, wound healing, and post-burn care (16,17).PRP has been studied in recent years as an alternative treatment for anosmia (12,18).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Platelet-Rich Plasma as an Adjuvant Therapy to Endoscopic Sinus Surgery in Anosmia Patients with Sinonasal Polyposis: A Randomized Controlled Clinical Trial

Tabrizi

Asadi

Mohammadi

et al. 2021

Med. J. Islam. Republ. Iran

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Section: Introductionmentioning

confidence: 99%

Efficacy of Platelet-Rich Plasma as an Adjuvant Therapy to Endoscopic Sinus Surgery in Anosmia Patients with Sinonasal Polyposis: A Randomized Controlled Clinical Trial

Tabrizi

Asadi

Mohammadi

et al. 2021

Med. J. Islam. Republ. Iran

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“…Among the studies in the literature conducted in the field of otolaryngology, there are various studies demonstrating the positive effects of PRP on tissue regeneration in tympanic membrane perforations, after rhinoplasty operations, after septoplasty and endoscopic sinus surgery by being absorbed into nasal packings, in vocal cord injuries and acute facial nerve injuries ( 14 , 15 , 16 , 17 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

Protective and Therapeutic Effect of Platelet-Rich Plasma on Experimental Cisplatin Ototoxicity

Gözaydın,

Ünal,

Özdemir

et al. 2023

TAO

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Objective: Cisplatin is a chemotherapeutic agent with an ototoxic effect that is frequently used in head and neck cancers. There are studies in the literature conducted with various antioxidant substances to protect and/or prevent ototoxicity. This study aims to investigate whether platelet-rich plasma (PRP) has a protective and therapeutic effect on cisplatin ototoxicity. Methods: A total of 40 Sprague Dawley albino rats were divided into six groups as control group (n=6), PRP-only group (n=6), cisplatin group (n=6), cisplatin + PRP group (n=6), PRP + cisplatin group (n=6), and donor group (n=10). At the beginning of the study and the 8 th day, they were tested with distortion product otoacoustic emission (DPOAE). Assessment of DPOAE results was based on the signal-to-noise ratio in 2000, 3000, 4000, 6000, and 8000 Hz frequency bands. On the 8 th day, the rats were sacrificed. For histological examinations, the temporal bones were dissected and fixed. After hematoxylin and eosin staining, the tissues were evaluated by light microscopy. Results: In the DPOAE tests performed on the 0 th and 8 th days of the cisplatin group, it was observed that cisplatin caused hearing loss in the rat ears. It was determined that the cisplatin group at 2000 Hz, 3000 Hz and 4000 Hz had a significant decrease in hearing compared to all groups (p<0.015), while the cisplatin group at 6000 and 8000 Hz was characterized by hearing loss at a higher rate than all groups (p<0.001). At the end of the study, negative effects of cisplatin on both cellular dimensions (cytoplasmic vacuolization, cell degeneration, dilatation, apoptotic cells, nerve degeneration) and hearing function were observed. No protective or therapeutic effect of PRP on cisplatin ototoxicity was observed. Conclusion: Our study showed that platelet-rich plasma did not have a significant effect in the treatment of hearing loss due to cisplatin ototoxicity and in preventing hearing loss in rats.

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“…They found significant improvements in crusting and bleeding, as well as mucocilliary clearance [ 238 ]. Kuzucu et al conducted a study of 25 patients receiving standard nasal packs infused with PVRP and reported lower NOSE scores, less bleeding and crust formation compared to the control group, where the subjects received only saline nasal packing, confirming the hypothesis of accelerated healing in the septal and conchal mucosa [ 239 ].…”

Section: Use Of Plasma Rich With Platelets and Extracellular Vesicles...mentioning

confidence: 99%

Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

Troha

Vozel

Arko

et al. 2023

IJMS

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The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.

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Effects of the Autologous Platelet-Rich Plasma in Nasal Pack on Postoperative Quality of Life

Abstract: According to the authors' study on PRP, the authors found out that by using PRP wound can be healed faster in early period of postoperative. It was seen with the authors' research that on postoperative early period crusts, bleeding and postoperative complaints are lesser.

Cited by 12 publications

References 9 publications

Efficacy of Platelet-Rich Plasma as an Adjuvant Therapy to Endoscopic Sinus Surgery in Anosmia Patients with Sinonasal Polyposis: A Randomized Controlled Clinical Trial

Efficacy of Platelet-Rich Plasma as an Adjuvant Therapy to Endoscopic Sinus Surgery in Anosmia Patients with Sinonasal Polyposis: A Randomized Controlled Clinical Trial

Protective and Therapeutic Effect of Platelet-Rich Plasma on Experimental Cisplatin Ototoxicity

Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

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