Effects of the ancillary ligands of polypyridyl ruthenium(ii) complexes on the DNA-binding behaviors

Two New Co(II) and Ni(II) Complexes with 3-(2-Pyridyl)pyrazole-Based Ligand: Synthesis, Crystal Structures, and Bioactivities

“…170.78 (13) metal ions with the ligand L. Moreover, when the results were compared with that of Cu(II) and Zn(II) complexes previously reported, [19][20][21] it can be seen that 1 showed equivalently cytotoxicity against HL-60 but lower activity against BGC-823 and MDA-MB-435. On the other hand, among these three cancer cells lines, HL-60 was the most sensitive to the tested compounds (1, 2 and L) with inhibitory rate ranged from Ϫ5.42 to 89.29%.…”

“…Usually, their anti-tumor activities can increase more or less compared with those of either the free ligands or metal ions alone, which may be due to the different binding properties of these complexes to DNA. [10][11][12][13] It is necessary to understand the DNA binding properties for developing new potential DNA targeting anti-tumor drugs. In general, metal complexes interact with double helix DNA in either non-covalent or covalent way, the former including three binding modes, namely, intercalation, groove binding and external static electronic effects.…”

Synthesis, Characterization and DNA Binding Studies of [Ruthenium(II)(bpy)2L]2+ where L are Derivatives of imidazo[4,5-f]-1,10-phenanthrolines

“…The studies on the binding of Ru(II) complexes with DNA have become prominent recently, investigating the binding mode either reversible or non-covalent. Numerous reports have been published on the DNA binding of metal complexes with bipyridyl ligands (Kumar et al 2010;Narra et al 2006;Xiong & Ji 1999) and significant effect on the spectral and DNA binding behaviour of the complexes were observed through varying the ancillary ligands of metal complexes (Liu et al 2001;Xu et al 2003).…”

Synthesis, characterization and DNA binding and photocleavage studies of [Ru(bpy)2BDPPZ]2+, [Ru(dmb)2BDPPZ]2+ and [Ru(phen)2BDPPZ]2+ complexes and their antimicrobial activity

“…[11] Since many useful applications require that the complexes bind to DNA in an intercalative mode, much work has been done on modifying intercalative ligands, and the influence of ancillary ligands on DNA binding. [12] Arockiasamy et al [13] studied the binding and photocleavage studies of new ruthenium(II) complexes [Ru(bpy) 2 HBT] 2+ and [Ru(phen) 2 HBT] 2+ (HBT = 11H,13H-4,5,9,10,12,14 hexaazabenzo [b]triphenylene). As the ruthenium(II) polypyridyl complexes bind to DNA in three dimensions, the ancillary ligands can also play an important role in governing the DNA binding.…”