Effects of the Administration of Probiotics on Fecal Microbiota Diversity and Composition in Healthy Individuals

Noh, Choong‐Kyun; Kim, Bong Sun; Hong, Gana; Cheong, Jae Youn; Lee, Kwang Jae

doi:10.5056/jnm17140

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…Such interesting results also occurred in this study, which showed various responses to probiotic administrations in different enterotypes. The α‐diversity did not change significantly in two enterotypes after the administration of probiotics, which is consistent with previous findings that the α‐diversity of intestinal flora was not significantly affected by the administration of probiotics (Noh et al., 2018 ). Examinations of the β‐diversity indicated that the samples that belonged to the same individual mostly clustered together regardless of the probiotic interventions.…”

Section: Discussionsupporting

confidence: 92%

Effect of the administration of probiotics on the fecal microbiota of adult individuals

Zhao

Jin

Shen

et al. 2021

Food Science & Nutrition

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Probiotics have been used to ameliorate ailments by modulating gut microbiota. However, to date, the effects of probiotic supplementation on the composition of fecal microbiota in healthy adults remain obscure. In this study, nine healthy volunteers were recruited to take probiotics (a mixture of Lactobacillus casei Zhang, L. plantarum P‐8, and Bifidobacterium lactis V9, 2:2:3, 1 × 1010 CFU/day) for 28 days. The fecal samples were collected at 0 and 28 days, and V4 of the 16S rRNA gene sequenced by Illumina MiSeq was used to analyze the fecal microbiota. The enterotype has been used to characterize the composition of gut microbiota. Nine adults were divided into Type P (fecal microbiota dominated by Prevotella, 4 adults) and Type B (fecal microbiota dominated by Bacteroides, 5 adults) based on an enterotype analysis. The responses of variation had been found in two enterotypes. The α‐diversity was not changed significantly after the administration of probiotics in both Type P and B. However, the community structure in Type B was substantially influenced. After the administration of probiotics, Weissella and Leuconostoc were significantly higher in Type P, while Collinsella significantly increased in Type B. The different pathways involving pathogen infections were downregulated at 28 days. The Type VI secretion system and the EHEC/EPEC pathogenicity signature were downregulated in Type B and Type P, respectively.

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Section: Discussionsupporting

confidence: 92%

Effect of the administration of probiotics on the fecal microbiota of adult individuals

Zhao

Jin

Shen

et al. 2021

Food Science & Nutrition

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“…The evidence is not high quality, however, as the studies have been limited by significant heterogeneity in terms of types of bacteria used, timing of administration, and quality of the studies as well as the fact that the majority of these studies were performed prior to more recent breakthroughs in microbiome analysis. Notably, 4-week administration of probiotics to healthy volunteers does not alter gut microbiota [ 76 ]. However, there are questions about sustainability after probiotic administration as well as geographic variation in the intestine whereby the microbiota might resist or enhance colonization based upon probiotic effects [ 77 ].…”

Section: Therapeutic Approaches Targeting the Intestinementioning

confidence: 99%

Gut integrity in critical illness

2019

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BackgroundThe gut is hypothesized to be the “motor” of critical illness. Under basal conditions, the gut plays a crucial role in the maintenance of health. However, in critical illness, all elements of the gut are injured, potentially worsening multiple organ dysfunction syndrome.Main bodyUnder basal conditions, the intestinal epithelium absorbs nutrients and plays a critical role as the first-line protection against pathogenic microbes and as the central coordinator of mucosal immunity. In contrast, each element of the gut is impacted in critical illness. In the epithelium, apoptosis increases, proliferation decreases, and migration slows. In addition, gut barrier function is worsened via alterations to the tight junction, resulting in intestinal hyperpermeability. This is associated with damage to the mucus that separates the contents of the intestinal lumen from the epithelium. Finally, the microbiome of the intestine is converted into a pathobiome, with an increase in disease-promoting bacteria and induction of virulence factors in commensal bacteria. Toxic factors can then leave the intestine via both portal blood flow and mesenteric lymph to cause distant organ damage.ConclusionThe gut plays a complex role in both health and critical illness. Here, we review gut integrity in both health and illness and highlight potential strategies for targeting the intestine for therapeutic gain in the intensive care unit.

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“…In the past few decades, foodborne probiotics have drawn great research interest in food nutrition and human health. − Therein, lactic acid bacteria (LAB), used for thousands of years for production and preservation of fermented food, have been proven to possess health-promoting properties and have become one of the most commonly consumed dietary supplements. − Many probiotics have shown diverse benefits, such as growth inhibition of pathogenic bacteria, alleviation of constipation, improved barrier function of intestinal epithelial cells, stimulation of the immune response, and maintaining the homeostasis of the gastrointestinal tract. Although probiotics have lots of special functions and benefits to human health, in vivo behaviors and metabolism, biodistribution, and related immunomodulation of foodborne probiotics are still currently poorly studied.…”

Section: Introductionmentioning

confidence: 99%

In-Taken Labeling and in Vivo Tracing Foodborne Probiotics via DNA-Encapsulated Persistent Luminescence Nanoprobe Assisted Autofluorescence-Free Bioimaging

Liu

Zhao

Wang

et al. 2018

J. Agric. Food Chem.

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An in vivo probing strategy that can real-time and in situ trace target probiotics inside the living body is herein proposed by employing plasmid-like DNA as in-taken assistance, persistent luminescence nanophosphors (PLNPs) as optical labeling, and background-free fluorescence bioimaging as signal readout. PLNPs with superlong afterglow and excellent biocompatibility and stability were surface-modified by DNA molecules with a specific sequence, which greatly promoted the nanoparticle penetration into the bacteria and facilitated the in vivo bioimaging with high sensitivity and signal-to-noise ratio. Compared with the previous surface-labeling strategy by antibody recognition, the in-taken optical labeling demonstrated improved stability, and reached ideal results of real-time and in situ monitoring the in vivo behaviors of target probiotics, supporting the further development of in vivo investigation methodology for foodborne probiotics. Moreover, such a strategy offers a promising platform that leverage nanoscience to food nutrition as well as food-safety research, aiming to collect more accurate and fresh information from the living body.

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Effects of the Administration of Probiotics on Fecal Microbiota Diversity and Composition in Healthy Individuals

Cited by 12 publications

References 31 publications

Effect of the administration of probiotics on the fecal microbiota of adult individuals

Effect of the administration of probiotics on the fecal microbiota of adult individuals

Gut integrity in critical illness

In-Taken Labeling and in Vivo Tracing Foodborne Probiotics via DNA-Encapsulated Persistent Luminescence Nanoprobe Assisted Autofluorescence-Free Bioimaging

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