Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive–compulsive disorder

Effects of Saffron Aqueous Extract and Its Main Constituent, Crocin, on Health-Related Quality of Life, Depression, and Sexual Desire in Coronary Artery Disease Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

“…Moreover, it has shown a functional interaction with the serotonergic system (32). On the other hand, some neurotransmitters, such as dopamine and serotonin, are dramatically affected in depression.…”

Saffron: a natural product with potential pharmaceutical applications

“…[49] 40 adult patients with mild to moderate depression (Hamilton Rating Scale: [18][19][20][21][22][23][24][25] were randomized to C. sativus 15-mg bid versus fluoxetine 10-mg bid.…”

“…[1,3,[7][8][9][10][11][12][13][14] In parallel, the possible uses of saffron and its active constituents lead to an increasing number of research studies, some of which have drawn some very useful and intriguing results of active ingredients of saffron, especially against malignancies, cardiovascular and Alzheimer's disease. [15][16][17][18][19][20][21][22] In this minireview, we aim to summarize and critically address previous and current evidence regarding the biological/ pharmacological activities of saffron and its active ingredients and their possible therapeutic uses. The history and structural features of saffron constituents are given in the first part of the review, followed by a comprehensive and critical presentation of the published preclinical and clinical studies and review papers on the pharmacology and potential therapeutic applications of saffron and its main active components.…”

Effect of Saffron (Crocus Satious L.) as an Add-On Therapy to Sertraline in Mild to Moderate Generalized Anxiety Disorder: A Double Blind Randomized Controlled Trial

“…Experimental evidence indicated to the anxiolytic effect the crocin (17,21). In a study carried out in mice, low doses of the aqueous extracts of saffron (56 and 80 mg/kg) and safranal (0.15 and 0.35 mL/kg) caused anxiolytic like effects, not different from that of diazepam (3 mg/kg), explained by increment in the time spent in the open arms of an elevated plus maze (18).…”