Effects of the 1-alkyl-3-methylimidazolium bromide ionic liquids on the antioxidant defense system of Daphnia magna

Yu, Miao; Wang, Sanhu; Luo, Yu; Han, Yanyan; Li, Xiaoyü; Zhang, Bangjun; Wang, Jianji

doi:10.1016/j.ecoenv.2009.05.002

Cited by 119 publications

(62 citation statements)

References 67 publications

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“…ILs based on imidazolium, pyridinium, phosphonium, and ammonium have been tested on Cyclotella meneghiniana, Selenastrum capricornutum, Daphnia magna, Pseudokirchneriella subcapitata, and zebrafish (Latala et al, 2005;Pretti et al, 2009;Yu et al, 2009). It was found that shorter alkyl-substituted chains demonstrated lower toxicity compared with the cations with a longer alkyl substituent.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Inhibitory Effects ofN-Butylpyridinium Chloride and Structurally Related Ionic Liquids on Organic Cation Transporters 1/2 and Human Toxic Extrusion Transporters 1/2-K In Vitro and In Vivo

Cheng¹,

Martinez-Guerrero²,

Wright³

et al. 2011

Drug Metab Dispos

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ABSTRACT:Ionic liquids (ILs) are a class of salts that are expected to be used as a new source of solvents and for many other applications. Our previous studies revealed that selected ILs, structurally related organic cations, are eliminated exclusively in urine as the parent compound, partially mediated by renal transporters. This study investigated the inhibitory effects of N-butylpyridinium chloride (NBuPy-Cl) and structurally related ILs on organic cation transporters (OCTs) and multidrug and toxic extrusion transporters (MATEs) in vitro and in vivo. After Chinese hamster ovary cells expressing rat (r) OCT1, rOCT2, human (h) OCT2, hMATE1, or hMATE2-K were constructed, the ability of NBuPy-Cl, 1-methyl-3-butylimidazolium chloride (Bmim-Cl), N-butyl-N-methylpyrrolidinium chloride (BmPyCl), and alkyl substituted pyridinium ILs to inhibit these transporters was determined in vitro. NBuPy-Cl (0, 0.5, or 2 mg/kg per hour) was also infused into rats to assess its effect on the pharmacokinetics of metformin, a substrate of OCTs and MATEs. NBuPy-Cl, Bmim-Cl, and BmPy-Cl displayed strong inhibitory effects on these transporters (IC 50 ‫؍‬ 0.2-8.5 M). In addition, the inhibitory effects of alkyl-substituted pyridinium ILs on OCTs increased dramatically as the length of the alkyl chain increased. The IC 50 values were 0.1, 3.8, 14, and 671 M (hexyl-, butyl-, and ethyl-pyridinium and pyridinium chloride) for rOCT2-mediated metformin transport. Similar structurally related inhibitory kinetics were also observed for rOCT1 and hOCT2. The in vivo coadministration study revealed that NBuPy-Cl reduced the renal clearance of metformin in rats. These results demonstrate that ILs compete with other substrates of OCTs and MATEs and could alter the in vivo pharmacokinetics of such substrates.

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Section: Introductionmentioning

confidence: 99%

Characterization of the Inhibitory Effects ofN-Butylpyridinium Chloride and Structurally Related Ionic Liquids on Organic Cation Transporters 1/2 and Human Toxic Extrusion Transporters 1/2-K In Vitro and In Vivo

Cheng¹,

Martinez-Guerrero²,

Wright³

et al. 2011

Drug Metab Dispos

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“…No other acclimation was conducted (laboratory conditions are 24 ±1 °C and a 16:8 h photoperiod). Therefore, individuals that were not fed were used in this assay (Yu et al, 2009). Individuals were checked every day at the same hour in terms of mortality and reproductive state (presence of eggs or offspring) and transferred to freshly filtrated lake water every day (Gonçalves and Mikulski, 2006).…”

Section: Laboratory Conditionsmentioning

confidence: 99%

Effects of salinity tolerances on survival and life history of 2 cladocerans

Gökçe¹,

Turhan²

2014

Turk J Zool

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“…Yu and co-workers reported the toxicity study of 1-alkyl-3-methylimidazolium bromide ionic liquids towards the antioxidant defence system of Daphnia Magna. [87] Increasing the length of alkyl side chain was found again to increase toxicity. Toxicity of ionic liquids in this case was due to oxidative stress in Daphnia Magna, which was evaluated by measuring the activity of antioxidant defence enzymes, levels of the antioxidant glutathione and malondialdehyde i.e.…”

Section: Toxicity and Eco(toxicity) Of Ionic Liquidsmentioning

confidence: 99%

Safer and Greener Catalysts – Design of High Performance, Biodegradable and Low Toxicity Ionic Liquids

Gore¹,

Gathergood²

2013

Ionic Liquids - New Aspects for the Future

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Effects of the 1-alkyl-3-methylimidazolium bromide ionic liquids on the antioxidant defense system of Daphnia magna

Cited by 119 publications

References 67 publications

Characterization of the Inhibitory Effects ofN-Butylpyridinium Chloride and Structurally Related Ionic Liquids on Organic Cation Transporters 1/2 and Human Toxic Extrusion Transporters 1/2-K In Vitro and In Vivo

Characterization of the Inhibitory Effects ofN-Butylpyridinium Chloride and Structurally Related Ionic Liquids on Organic Cation Transporters 1/2 and Human Toxic Extrusion Transporters 1/2-K In Vitro and In Vivo

Effects of salinity tolerances on survival and life history of 2 cladocerans

Safer and Greener Catalysts – Design of High Performance, Biodegradable and Low Toxicity Ionic Liquids

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