Effects of testosterone on<i>Heterakis spumosa</i>infections in mice

Harder, Achim; Wunderlich, Frank; Marinovski, Predrag

doi:10.1017/s0031182000074266

Cited by 35 publications

(15 citation statements)

References 29 publications

(25 reference statements)

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“…Males have higher blood levels of testosterone, a hormone presumed to have an immunosuppressive effect (Owens and Wilson 1999). Testosterone supplementation can reduce spleen size in mice (Harder et al 1992). We consider that this factor may explain the sexdependent nature of the relationships between nematode abundance and body condition and between spleen size and colour brightness…”

Section: Fig 1 Relationship Between Body Mass (Standardized By Regrmentioning

confidence: 96%

Do carotenoids and spleen size vary with helminth load in greylag geese?

Figuerola¹,

Torres²,

Garrido³

et al. 2005

Can. J. Zool.

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It has been suggested that carotenoid-derived coloration serves as an indicator of parasite levels and (or) the general health of birds. We investigated relationships among spleen size (sometimes considered an indicator of the cellular immune response capacity of birds), carotenoid level, helminth load, and leg and bill coloration of greylag geese, Anser anser (L., 1758), from Doñana National Park (southwest Spain). Nematode abundance was positively related to spleen size and negatively to body condition, but only in males. Coloration of bill and legs was a reliable indicator of cestode but not nematode abundance. Individuals with many cestodes had greater carotenoid stores, suggesting that helminths do not limit carotenoid absorption. Rather, it suggests either that parasitized geese were accumulating more carotenoids to control parasite-induced damage, or that carotenoid-rich diets expose geese to more intermediate hosts of cestodes. Our results support the role of integumentary carotenoid-derived coloration as an indicator of parasitism, but only for particular taxonomic groups.

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Section: Fig 1 Relationship Between Body Mass (Standardized By Regrmentioning

confidence: 96%

Do carotenoids and spleen size vary with helminth load in greylag geese?

Figuerola¹,

Torres²,

Garrido³

et al. 2005

Can. J. Zool.

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“…According to Harder et al 15 , rodent males would be more susceptible to parasitic infections because of the deleterious effect of testosterone, which impairs the hosts' immunological response. However, Eloi-Santos et al 10 found that Schistosoma mansoni cercariae were more successful in developing into adult worms in experimentally infected female mice, when compared to male mice exposed to the same number of cercariae.…”

Section: Tablementioning

confidence: 99%

Migration pattern of Toxocara canis larvae in experimentally infected male and female Rattus norvegicus

Santos

Lescano

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Migration of Toxocara canis larvae was investigated in male and female Rattus norvegicus. Methods: Eighteen male and 18 female R. norvegicus were infected with 300 T. canis eggs. Three male and three female rats were euthanized at 3, 7, 10, 15, 30, and 60 days post-infection, and T. canis larvae were recovered by means of organ and tissue digestion. Results: Female rats showed a greater number of larvae in the liver than males. Conclusions: Paratenic host sex influences the migration pattern of T. canis larvae.

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“…Testosterone treatment in mice aects the development and growth of another nematode, Heterakis spumosa, by prolonging the period of infection (Harder et al 1992). It has also been reported that S. ratti L3 migration is aected by the temperature and sodium concentration to which the parasites are exposed (Tobata and Shimada 1996;personal communication).…”

Section: Discussionmentioning

confidence: 98%

Strongyloides ratti : additive effect of testosterone implantation and carbon injection on the susceptibility of female mice

Watanabe

Hamano

Noda

et al. 1999

Parasitology Research

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A sex-related difference in host susceptibility to Strongyloides ratti was previously known. Male mice were more susceptible to S. ratti infection and the difference was seen against migrating larvae under the regulation of testosterone. Against migrating larvae, macrophages were assumed to play important roles in host natural immunity. On the basis of these findings, to examine the effect of testosterone on macrophages we treated female mice with testosterone and/or carbon to block the function of macrophages. Mice were then infected with third-stage larvae of S. ratti. By counting of the migrating larvae in the cranial cavity at 36 h after infection the effect of each treatment was assayed. Testosterone treatment alone (Te) or carbon injection alone (Ca) effectively increased the worm recovery. Given together, Te and Ca (Te + Ca) significantly increased the worm recovery to levels almost equal to the sum of those achieved with Te and Ca. The serum testosterone concentration was elevated in mice that had undergone Te and Te + Ca at the time of worm recovery. Surprisingly, the serum testosterone concentration reached after Te + Ca was elevated more than that attained by Te. The same experiment with a half-dose of Te and Ca (Te half + Ca) resulted in the same testosterone concentration achieved with Te and resulted in a worm recovery almost equal to the sum of that achieved with Te and Ca. These results clearly showed that Te and Ca had an additive effect on the recovery of migrating S. ratti larvae. Testosterone had an effect after macrophages had been blocked. The relationship between testosterone and macrophage function during S. ratti infection is discussed.

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Effects of testosterone onHeterakis spumosainfections in mice

Cited by 35 publications

References 29 publications

Do carotenoids and spleen size vary with helminth load in greylag geese?

Do carotenoids and spleen size vary with helminth load in greylag geese?

Migration pattern of Toxocara canis larvae in experimentally infected male and female Rattus norvegicus

Strongyloides ratti : additive effect of testosterone implantation and carbon injection on the susceptibility of female mice

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