Effects of tenuifolin extracted from radix polygalae on learning and memory: A behavioral and biochemical study on aged and amnesic mice

Zhang, Hong; Han, Ting; Zhang, Lei; Yu, Chenghao; De-guang, Wan; Rahman, Khalid; Qin, Lu‐Ping; Peng, Cheng

doi:10.1016/j.phymed.2007.12.004

Cited by 90 publications

(71 citation statements)

References 25 publications

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“…Cistanche deserticola Ma has been used as memory enhancer in Asia for thousands of years. Various animal models have demonstrated that Cistanche deserticola Ma can improve brain functions [15]. In the present study, the memoryenhancing effects of CDME on normal aged mice were investigated by using an open-field test.…”

Section: Discussionmentioning

confidence: 93%

“…Cistanche deserticola Ma (Orobanchaceae) is a well-known medicinal shrub-like herb that has been commonly used as memory enhancer in China. Cistanche deserticola Ma (Orobanchaceae) extract (CDME) is also included in some traditional prescriptions for treating central nervous system disturbances [4][5][6]. This study was designed to investigate the effects of CDME on learning and memory impairment in normal aged mice.…”

Section: Introductionmentioning

confidence: 99%

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Effect of <i>Cistanche deserticola</i> Ma extract on memory of aged mice

Guifang¹,

Yin²,

Zhang³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of <i>Cistanche deserticola</i> Ma extract on memory of aged mice

Guifang¹,

Yin²,

Zhang³

et al. 2017

Trop. J. Pharm Res

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“…Oral administration of tenuifolin extracted from RP evidently improved latency and the number of errors in aged mice. Moreover, tenuifolin at the same dose increases the relative levels of norepinephrine and dopamine in the hippocampus of aged mice, and decreases AChE activity in the cortex [43]. A root extract of P. tenuifolia also induces the proliferation of a stem cell population in the rat hippocampal CA1 region [49].…”

Section: Polygala Tenuifoliamentioning

confidence: 98%

“…Polygalasaponins are the main constituents of this plant responsible for cognitive improvement. There is growing support for improved memory function in many animal models [41][42][43]. BT-11, an ethanolic extract of Polygala root, is effective against scopolamine-induced cognitive impairment in passive avoidance response and water maze tests [44], as well as improving stress-induced memory deficits in rats [45].…”

Section: Polygala Tenuifoliamentioning

confidence: 99%

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

Kumar

Song

et al. 2013

Molecules

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Abstract:Hanbang, the Traditional Korean Medicine (TKM), is an inseparable component of Korean culture both within the country, and further afield. Korean traditional herbs have been used medicinally to treat sickness and injury for thousands of years. Oriental medicine reflects our ancestor's wisdom and experience, and as the elderly population in Korea is rapidly increasing, so is the importance of their health problems. The proportion of the population who are over 65 years of age is expected to increase to 24.3% by 2031. Cognitive impairment is common with increasing age, and efforts are made to retain and restore the cognition ability of the elderly. Herbal materials have been considered for this purpose because of their low adverse effects and their cognitive-enhancing or anti-dementia activities. Herbal materials are reported to contain several active compounds that have effects on cognitive function. Here, we enumerate evidence linking TKMs which have shown benefits in memory improvements. Moreover, we have also listed Korean herbal formulations which have been the subject of scientific reports relating to memory improvement.

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“…It has been generally recognized that traditional Chinese herbal medicines play a unique therapeutic role in the treatment of many diseases (Zhang et al, 2008a;Du et al, 2009;Wu et al, 2009;Xing et al, 2009). Particularly, essential oils (EO) from many plant species have become popular in recent years, and the investigations on their bioactivities and mechanisms of action have been carried out for human health (Zhang et al, 2007(Zhang et al, , 2008bSamarth et al, 2008).…”

Section: Short Communicationmentioning

confidence: 99%