Effects of temperature on diffusion from PNIPA-based gels in a BioMEMS device for localized chemotherapy and hyperthermia

Oni, Y.; Theriault, Christian; Hoek, A. van; Soboyejo, W.O.

doi:10.1016/j.msec.2010.07.016

Cited by 23 publications

(18 citation statements)

References 41 publications

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“…Further experiments showed the time lag increases with length of the channel and flow is diffusion controlled that is affected by shape and materials in the channel. [ 13 ] Similar results were obtained using the cancer drug, biosynthesized prodigiosin. [ 15 ]…”

Section: Polymer-metal Compositessupporting

confidence: 53%

“…We have reported different in-vitro simultaneous hyperthermia and drug release studies. [ 13 , 15 ] As with the previous device, the conditions of hyperthermia were achieved based on Joule heating. In a proof of concept experiment, the pulsatile release of rhodamine dye from the device was compared to an unencapsulated PNIPA gel.…”

Section: Polymer-metal Compositesmentioning

confidence: 99%

“…The results showed that about 60% and 90% of the dye was released by the device and unencapsulated gel respectively after 5-min long activation (hyperthermia conditions) period every 15 min for a total of nine cycles. [ 13 ] The authors attributed the difference to the time lag associated with diffusion of drugs through the channels in the PDMS shell. Further experiments showed the time lag increases with length of the channel and flow is diffusion controlled that is affected by shape and materials in the channel.…”

Section: Polymer-metal Compositesmentioning

confidence: 99%

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Polymeric composite devices for localized treatment of early-stage breast cancer

2017

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For early-stage breast cancers mastectomy is an aggressive form of treatment. Therefore, there is a need for new treatment strategies that can enhance the use of lumpectomy by eliminating residual cancer cells with limited side effects to reduce local recurrence. Although, various radiotherapy-based methods have been developed, residual cells are found in 20–55% of the time at the first operation. Furthermore, some current treatment methods result in poor cosmesis. For the last decade, the authors have been exploring the use of polymeric composite materials in single and multi-modal implantable biomedical devices for post-operative treatment of breast cancer. In this paper, the concept and working principles of the devices, as well as selected results from experimental and numerical investigations, are presented. The results show the potential of the biomedical implants for cancer treatment.

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Section: Polymer-metal Compositessupporting

confidence: 53%

Section: Polymer-metal Compositesmentioning

confidence: 99%

Section: Polymer-metal Compositesmentioning

confidence: 99%

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Polymeric composite devices for localized treatment of early-stage breast cancer

2017

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“…The feasibility of heat activated flow of drugs through micro channels to biological media has been reported previously by our research group. 53 The results of the fluid flow visualization experiments at the different flow rates showed evidence of how cancer drugs can be eluted from the micro channels to the surrounding media. The results also showed that higher internal pressure results in higher flow rates and fluid elution from the channels to the surrounding media.…”

Section: D Implicationsmentioning

confidence: 99%

“…The results also showed that higher internal pressure results in higher flow rates and fluid elution from the channels to the surrounding media. 53 However, further experiments are needed to explore the synergistic effects of the heat and drugs on the targeted area, and the diffusion of drug to the targeted area.…”

Section: D Implicationsmentioning

confidence: 99%