Effects of technology or maternal factors on perinatal outcome after assisted fertilisation: a population-based cohort study

Congenital anomalies and other perinatal outcomes in ICSI vs. naturally conceived pregnancies: a comparative study

“…However, a recent population-based cohort study, assessed differences in singletons born to 2,546 Norwegian women who had conceived at least one child spontaneously and another after assisted conception. Their results demonstrated that the birth weight, gestational age, and risks of small for gestational age babies, and preterm delivery did not differ among infants of women who had conceived both spontaneously and after assisted fertilization [22]. In addition, in a retrospective case-control study of singleton children born after ICSI and a control group of normally conceived singleton children from Australia and the United Kingdom, it was demonstrated that more caesarean sections were performed in the case-patients, but this did not change the incidences of perinatal complications in the two groups, as were the rates of congenital anomalies [23] was shown that compared to spontaneously conceived singleton and twin pregnancies, IVF babies have no statistically significant differences in gestational age, birth weight, Apgar score, perinatal death, congenital defect [24].…”

Reduced protein C Global assay level in infertile women prior to IVF-ET treatment

“…increased risk of pre-term birth and low birth weight in singletons controlled for the maternal age [5][6][7][8][9][10]. Whether this increased rate of adverse pregnancy outcome in singleton pregnancies is related to ART practice; such as employment of medications, manipulation of gametes and use of culture media or to infertility per se, is still an open question.…”

Safety in Assisted Reproductive Technologies: Insights from Gene Expression Studies During Preimplantation Development

“…The studies were accused of design flows, including the retrospective nature of most of them. In addition, the debate was enlivened by several studies clashing with the evidence of safety risks associated with ART procedures: no evidence for worries in IVF/ICSI babies was in fact repeatedly reported (Bonduelle et al, 1996;Romundstad et al, 2008).…”

“…A large populationbased cohort study was carried out using sibling-relationship comparisons (women conceiving at least one child spontaneously and one after ART; Romundstad et al, 2008). Results suggested that the adverse outcomes of assisted fertilisation compared with those in the general population could be due to factors leading to infertility, rather than factors related to the reproductive technology.…”