Congenital anomalies and other perinatal outcomes in ICSI vs. naturally conceived pregnancies: a comparative study

Al-Fifi, Suliman H.; Al-Binali, Ali M.; Al-Shahrani, Mesfer; Shafiq, H; Bahar, Mohamad; Almushait, Mona; Sobandi, Lukanle; Eskandar, Mamdoh

doi:10.1007/s10815-009-9329-3

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…A large Australian study obtained from three registries in western Australia found that 8.6% of infants who were conceived with ICSI had a major birth defect, as compared with naturally conceived infants (OR for a major birth defect, 2; 95% CI = 1.3-3.2); however, in this study anomalies included were those reported up to 1 year of age [7]. A retrospective study from Saudi Arabia found a similar incidence of congenital fetal malformations [11], and similarly a Belgian study found no increased incidence of congenital malformations in ICSI children [12]. However, other studies did not show this increase.…”

Section: Discussioncontrasting

confidence: 55%

Ultrasonically detected fetal anomalies at mid-trimester scan in 1669 ICSI pregnancies compared with 3365 spontaneous pregnancies

Aboulghar

Serour

et al. 2012

Evidence Based Womenʼs Health Journal

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ObjectiveComparison of mid-trimester ultrasound-detected anomalies in inttracytoplasmic sperm Injection (ICSI) pregnancies with those in spontaneous pregnancies. Materials and methods A retrospective controlled study was conducted at a tertiary ultrasound referral center affiliated to a large in vitro fertilization (IVF) center. Pregnant women who conceived through ICSI (n = 1669) and those who conceived spontaneously (n = 3365) were compared with regard to incidence of congenital fetal malformations. ResultsThe number of ultrasonically detected anomalous fetuses in the ICSI group was 30 (1.3%) and that in the spontaneous pregnancy group was 66 (1.9%) [odds ratio (OR) 0.68; 95% confidence interval (CI) 0.44-1.05]. There were 14 anomalous fetuses in the ICSI singleton group and 63 in the spontaneous singleton group (OR 0.7; 95% CI 0.39-1.09). In the ICSI twin group there were 16 anomalous fetuses out of 637 twins and in the spontaneous group there were three anomalous fetuses out of 102 twins (OR 0.85; 95% CI 0.25-2.95). The incidence of singleton ICSI anomalies was 1.3% compared with 1.5% in twins in the ICSI group (OR 0.93; 95% CI 0.45-1.9). The types of anomalies were comparable in both groups. ConclusionThere is no significant difference in the incidence or type of ultrasound-detected anomalies in ICSI compared with spontaneous pregnancies in the examined sample of Egyptian women.

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Section: Discussioncontrasting

confidence: 55%

Ultrasonically detected fetal anomalies at mid-trimester scan in 1669 ICSI pregnancies compared with 3365 spontaneous pregnancies

Aboulghar

Serour

et al. 2012

Evidence Based Womenʼs Health Journal

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“…Of note, the potential negative impact of micromanipulation techniques should be considered, but only a few research studies have made precise distinctions between IVF and ICSI pregnancies [11,12,14]. …”

Section: Discussionmentioning

confidence: 99%

“…This fact can be explained partly by the high rate of multiple pregnancies as a result of these procedures, and by advanced maternal age [10], but past research has also focused on the potential negative impact of micromanipulation techniques, extended culture systems, and medications used in the context of IVF/ICSI [11,12]. …”

Section: Introductionmentioning

confidence: 99%

“…Although most pregnancies after IVF result in normal healthy outcomes, an increased risk for a number of obstetric and neonatal complications (such as preeclampsia, preterm delivery, lower average birth weight, and congenital malformations), compared to naturally conceived pregnancies, has been reported among singletons and twins [ 1 - 9 ]. This fact can be explained partly by the high rate of multiple pregnancies as a result of these procedures, and by advanced maternal age [ 10 ], but past research has also focused on the potential negative impact of micromanipulation techniques, extended culture systems, and medications used in the context of IVF/ICSI [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Obstetric and perinatal outcomes in IVF versus ICSI-conceived pregnancies at a tertiary care center - a pilot study

Nouri

Ott

Stoegbauer

et al. 2013

Reprod Biol Endocrinol

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BackgroundAlthough most pregnancies after IVF result in normal healthy outcomes, an increased risk for a number of obstetric and neonatal complications, compared to naturally conceived pregnancies, has been reported. While there are many studies that compare pregnancies after assisted reproductive techniques with spontaneously conceived pregnancies, fewer data are available that evaluate the differences between IVF and ICSI-conceived pregnancies. The aim of our present study was, therefore, to compare obstetric and perinatal outcomes in pregnancies conceived after in vitro fertilization (IVF) versus intracytoplasmatic sperm injection (ICSI).MethodsThree-hundred thirty four women who had become pregnant after an IVF or ICSI procedure resulted in a total of 530 children referred between 2003 und 2009 to the Department of Obstetrics and Gynecology of the Medical University of Vienna, a tertiary care center, and were included in this retrospective cohort study. We assessed maternal and fetal parameters in both groups (IVF and ICSI). The main study outcomes were preterm delivery, the need for neonatal intensive care, and congenital malformations. Moreover, we compared the course of pregnancy between both groups and the occurrence of complications that led to maternal hospitalization during pregnancy.ResultsThere were 80 children conceived via ICSI and 450 children conceived via IVF.Mean gestational age was significantly lower in the ICSI group (p = 0.001). After ICSI, the birth weight (p = 0.008) and the mean APGAR values after 1 minute and after 10 minutes were lower compared to that of the IVF group (p = 0.016 and p = 0.047, respectively). Moreover, ICSI-conceived children had to be hospitalized more often at a neonatal intensive care unit (p = 0.004). There was no difference in pH of the umbilical artery or in major congenital malformations between the two groups. Pregnancy complications (i.e., premature rupture of membranes, cervical insufficiency, and premature uterine contractions) and the need for maternal hospitalization during pregnancy were found significantly more often after IVF (p = 0.0016 and p = 0.0095, respectively), compared to the ICSI group.ConclusionsWhen comparing IVF versus ICSI-conceived pregnancies at a tertiary care center, we found the course of pregnancy to be more complicated after IVF, whereas the primary fetal outcome seemed to be better in this group than after ICSI treatment.

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“…Single embryo transfer is now promoted which has reduced these complications. Despite this ART children still have a higher perinatal morbidity and mortality than matched controls (Al-Fifi et al, 2009;Helmerhorst et al, 2004). A systematic review found that for singletons the relative risk of a very preterm birth (<32 weeks) was 3.27 (95% CI 2.03 -5.28) after assisted conception (Helmerhorst et al, 2004).…”

Section: Adverse Perinatal Outcomesmentioning

confidence: 99%

Assisted Reproductive Technology and Congenital Malformations

Reed¹,

Sutcliffe²

2012

Congenital Anomalies - Case Studies and Mechanisms

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Congenital anomalies and other perinatal outcomes in ICSI vs. naturally conceived pregnancies: a comparative study

Abstract: Background Intracytoplasmic sperm injection (ICSI) procedures have become accepted worldwide and their effect on society is well-known. However, the full extent of the possible complications of these procedures on maternal and neonatal outcome is still unclear.

Cited by 17 publications

References 24 publications

Ultrasonically detected fetal anomalies at mid-trimester scan in 1669 ICSI pregnancies compared with 3365 spontaneous pregnancies

Ultrasonically detected fetal anomalies at mid-trimester scan in 1669 ICSI pregnancies compared with 3365 spontaneous pregnancies

Obstetric and perinatal outcomes in IVF versus ICSI-conceived pregnancies at a tertiary care center - a pilot study

Assisted Reproductive Technology and Congenital Malformations

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