Effects of tDCS on reward responsiveness and valuation in Parkinson’s patients with impulse control disorders

Terenzi, Damiano; Catalan, Mauro; Polverino, Paola; Bertolotti, Claudio; Manganotti, Paolo; Rumiati, Raffaella I.; Aiello, Marilena

doi:10.1007/s00415-021-10733-0

Cited by 11 publications

(20 citation statements)

References 45 publications

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“…This suggests potential for a behavioral screening approach. 15 The task we use is short, only 30 minutes, and can likely be signi cantly shortened. Development of such a screening tool would be a valuable addition to other more complex multisession interactions or neuroimaging based approaches.…”

Section: Resultsmentioning

confidence: 99%

“…14 In patients with ICD, increased subjective 'wanting' was observed when patients were on dopaminergic therapies. 15 These and related ndings raise questions regarding how 'subjective feelings' in the context of risky -dopamine-system engaging -behavior may differ in individuals at risk for developing ICD, but also the potential utility predictive measures of 'subjective feelings' may have in identifying neurobehavioral conditions that predispose patients to developing addiction and substance use disorders more generally.…”

Section: Introductionmentioning

confidence: 99%

“…Dopaminergic processes have previously been implicated in the modulation of subjective feelings and emotional changes induced by stimuli and substances in both behavioral and substance-based addiction disorders. [12][13][14][15] Positron Emission Tomography imaging has shown that patients with gambling disorder have increased dopamine release associated with higher levels of excitement while. 12 Increased D2-receptor availability has been shown to be associated with modulations of subjective feelings in Alcohol Use Disorder.…”

Section: Introductionmentioning

confidence: 99%

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Subjective Feelings associated with Expectations and Rewards during Risky Decision-making in Impulse Control Disorder

Kishida

Liebenow

Jiang

et al. 2022

Preprint

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Impulse Control Disorder (ICD) in Parkinson’s disease is a behavioral addiction induced by dopaminergic therapies, but otherwise unclear cognitive etiology. The current study investigates the influence of objective reward processing variables, dopaminergic therapy, and risky decision-making on ‘subjective feelings’ in patients with versus without ICD. Patients with (n = 18) and without (n = 12) a history of ICD secondary to Parkinson’s disease performed a risky decision-making task (on and off standard-of-care dopaminergic therapies). During the task, participants choose a ‘gamble’ or a ‘certain reward’ and report how they feel about decision outcomes. The subjective feeling of ‘pleasure’ is driven by different aspects of reward processing in patients with, versus without, a history of ICD. While off-medication, expectations about risky-decisions have a negative influence on subjective feelings in patients with a history of ICD versus a positive influence in patients without ICD. While on-medication, the influence of reward processing variables and recent experience on modulating subjective feelings in both patient groups are altered; patients with ICD become more emotionally reactive, whereas patients without ICD become less emotionally reactive. Computational modeling of risky decision-making behavior reveals latent factors that drive subjective feelings and risky behaviors in patients with versus without a history of ICD. Group differences are observed in off-medication states. Changes are induced in both groups with medication suggesting ICD-related decision-making may be driven by mechanisms associated with emotion regulation and that heightened dopaminergic processes may induce more reactive, less stable, emotion regulation in patients predisposed to developing ICD.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Subjective Feelings associated with Expectations and Rewards during Risky Decision-making in Impulse Control Disorder

Kishida

Liebenow

Jiang

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Neuroimaging studies have shown that the orbitofrontal cortex (OFC) (Plassmann et al, 2007) and the striatum (Knutson et al, 2007;Levy & Glimcher, 2012) have a crucial role in value processing (e.g., WTP for food) while brain regions including the dorsolateral prefrontal cortex (DLPFC) and the anterior cingulate cortex (ACC) may play a role in choice execution and choice conflict, respectively (Botvinick et al, 2004;Rangel & Hare, 2010;Terenzi, Catalan, et al, 2021). However, whether and how this neural network plays a role also in value changes driven by a gazecueing paradigm is unclear.…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates Underlying Social-Cue-Induced Value Change

et al. 2022

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As humans are social beings, human behavior and cognition are fundamentally shaped by information provided by peers, making human subjective value for rewards prone to be manipulated by perceived social information. Even subtle nonverbal social information, such as others' eye gazes, can influence value assignment, such as food value. In this study, we investigate the neural underpinnings of how gaze cues modify participants' food value (both genders) by means of functional magnetic resonance imaging. During the gaze-cuing task, food items were repeatedly presented either while others looked at them or while they were ignored by others. We determined participants' food values by assessing their willingness to pay before and after a standard gaze-cuing training. Results revealed that participants were willing to pay significantly more for food items that were attended to by others compared with the unattended to food items. Neural data showed that differences in subjective values between the two conditions were accompanied by enhanced activity in the inferior frontal gyrus, middle temporal gyrus, and caudate after food items were attended to. Furthermore, the functional connectivity between the caudate and the angular gyrus precisely predicted the individual differences in the preference shift. Our results unveil the key neural mechanism underlying the influence of social cues on the subjective value of food and highlight the crucial role of social context in shaping subjective value for food rewards in human. SIGNIFICANCE STATEMENT We investigated how social information like others' gaze toward foods affects individuals' food value. We found that individuals more often choose food items that were looked at by another person compared with food items that were ignored. Using neuroimaging, we showed that this increased value for attended to food items was associated with higher brain activity in the inferior frontal gyrus, middle temporal gyrus, and caudate. Furthermore, functional connectivity between the caudate and the angular gyrus was associated with individual differences in values for food items that were attended to by others versus being ignored. These findings provide novel insights into how the brain integrates social information into food value and could suggest possible interventions like using gaze cuing to promote healthier food choices.

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“…Clinically, PD is defined as a progressive movement disorder, including bradykinesia, rigidity, and rest tremor [ 7 , 8 ]. Furthermore, PD is often characterized by different nonmotor symptoms affecting sensory perception, cognition, mood, motivation, autonomic functions, and sleep, among others [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

2022

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An emerging body of literature suggests that long-term gut inflammation may be a silent driver of Parkinson’s disease (PD) pathogenesis. Importantly, specific nutritive patterns might improve gut health for PD risk reduction. Here, we review the current literature on the nutritive patterns and inflammatory markers as a predictor for early detection of PD. This knowledge might be used to foster the detection of early nutritive patterns and preclinical biomarkers to potentially alter PD development and progression.

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Effects of tDCS on reward responsiveness and valuation in Parkinson’s patients with impulse control disorders

Cited by 11 publications

References 45 publications

Subjective Feelings associated with Expectations and Rewards during Risky Decision-making in Impulse Control Disorder

Subjective Feelings associated with Expectations and Rewards during Risky Decision-making in Impulse Control Disorder

Neural Correlates Underlying Social-Cue-Induced Value Change

Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

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