Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

Terenzi, Damiano; Muth, Anne-Katrin; Park, Soyoung Q.

doi:10.3390/nu14142781

Cited by 3 publications

(2 citation statements)

References 177 publications

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“…Based on previous studies on schizophrenia ( 40 ), we also examined whether food intake indexed by certain nutrient compositions (e.g., carbs, fat, fruit, and vegetables) is associated with CAPE. More in details, high total intake of fruit and vegetables has been associated with better mental health ( 22 , 41 , 42 ). In line with this evidence, several studies reported a negative association between dietary intake of fruits and vegetables and the presence of psychosis ( 40 , 41 , 43 – 45 ).…”

Section: Resultsmentioning

confidence: 99%

Psychotic-like experiences in the lonely predict conspiratorial beliefs and are associated with the diet during COVID-19

et al. 2022

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The COVID-19 pandemic has increased the occurrence of conspiracy theories. It has been suggested that a greater endorsement of these theories may be associated with psychotic-like experiences (PLEs), as well as with social isolation. In this preregistered study, we investigated whether both PLEs and measures of social isolation (e.g., loneliness) can predict conspiratorial beliefs and, if so, which of these variables can mediate the association with conspiratorial beliefs. Furthermore, based on previous studies on schizophrenia, we explored whether the diet is associated with PLEs and conspiratorial beliefs. Participants (N = 142) completed online questionnaires measuring PLEs, social isolation, mental well-being, and conspiratorial beliefs. They also submitted their daily food intake for a week using a smartphone app. We found that loneliness predicted the endorsement of conspiracy theories during the COVID-19 lockdown. Strikingly, the proneness to experience subclinical psychotic symptoms played an underlying mediating role. In addition, these subclinical symptoms were associated with lower fruit, carbohydrate, and iron intakes, as well as with higher fat intake. Our results add insights into how conspiratorial beliefs can affect individuals’ mental health and relationships. Moreover, these results open the avenue for potential novel intervention strategies to optimize food intake in individuals with PLEs.

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Section: Resultsmentioning

confidence: 99%

Psychotic-like experiences in the lonely predict conspiratorial beliefs and are associated with the diet during COVID-19

et al. 2022

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“…Evidence from a systematic review involving 52 studies suggests that following a Mediterranean diet can reduce the onset and clinical progression of PD ( 138 ). Specific dietary patterns can regulate intestinal inflammation and influence the risk of PD ( 139 ). Western diet rich in refined carbohydrates and animal saturated fats, may have a harmful effect on the microbiota-gut-brain axis, which can lead to intestinal microbiome dysbiosis and increase bacteria containing a large amount of LPS, thus affecting intestinal barrier function and leading to endotoxemia, systemic inflammation, and mitochondrial dysfunction ( 140 ), which is associated with increased risk and deterioration of PD.…”

Section: Pd Therapy: Disease Remission Strategies Based On Regulation...mentioning

confidence: 99%

The role of the microbiota-gut-brain axis and intestinal microbiome dysregulation in Parkinson’s disease

Meng

Chen

et al. 2023

Front. Neurol.

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Parkinson’s disease (PD) is a complex progressive neurodegenerative disease associated with aging. Its main pathological feature is the degeneration and loss of dopaminergic neurons related to the misfolding and aggregation of α-synuclein. The pathogenesis of PD has not yet been fully elucidated, and its occurrence and development process are closely related to the microbiota-gut-brain axis. Dysregulation of intestinal microbiota may promote the damage of the intestinal epithelial barrier, intestinal inflammation, and the upward diffusion of phosphorylated α-synuclein from the enteric nervous system (ENS) to the brain in susceptible individuals and further lead to gastrointestinal dysfunction, neuroinflammation, and neurodegeneration of the central nervous system (CNS) through the disordered microbiota-gut-brain axis. The present review aimed to summarize recent advancements in studies focusing on the role of the microbiota-gut-brain axis in the pathogenesis of PD, especially the mechanism of intestinal microbiome dysregulation, intestinal inflammation, and gastrointestinal dysfunction in PD. Maintaining or restoring homeostasis in the gut microenvironment by targeting the gut microbiome may provide future direction for the development of new biomarkers for early diagnosis of PD and therapeutic strategies to slow disease progression.

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Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease

Santos

Oliveira

Noleto

et al. 2023

Neural Regeneration Research

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This critical review of the literature shows that there is a close link between the microbiome, the gut, and the brain in Parkinson’s disease. The vagus nerve, the main component of the parasympathetic nervous system, is involved in the regulation of immune response, digestion, heart rate, and control of mood. It can detect microbiota metabolites through its afferents, transferring this gut information to the central nervous system. Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression, as well as treatment responses. These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson’s disease. More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient’s benefit.

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Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

Cited by 3 publications

References 177 publications

Psychotic-like experiences in the lonely predict conspiratorial beliefs and are associated with the diet during COVID-19

Psychotic-like experiences in the lonely predict conspiratorial beliefs and are associated with the diet during COVID-19

The role of the microbiota-gut-brain axis and intestinal microbiome dysregulation in Parkinson’s disease

Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson’s disease

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