Effects of Taurine on Signal Transduction Steps Induced during Hypertrophy of Rat Heart Myocytes

Rao, Man-Ren; Liu, Tao

doi:10.1007/978-1-4899-0117-0_18

Cited by 14 publications

(10 citation statements)

References 10 publications

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“…For instance, studies have shown that taurine regulates myocardial Ca 2+ homeosta-sis through direct or indirect modulation of several key calcium transport systems 16 . Long-term exposure of heart myocytes to taurine decreased both nuclear and cytosolic Ca 2+ without significantly changing either nuclear or cytosolic Na + levels 14 . Changes in cytoplasmic Ca 2+ levels are involved in the regulation of a number of mammalian genes.…”

Section: Discussionmentioning

confidence: 86%

“…However, the signal pathway through which the taurine transporter gene is regulated by the availability of dietary taurine is unknown. The calcium ion (Ca 2+ ) is a fundamental agent for cell signaling, and there exist numerous examples of taurine-calcium interactions 14,16 . The present study demonstrates that the Ca 2+ signal may play an important role in the renal dietary adaptive regulation of taurine transporter gene expression demonstrated in LLC-PK1 cells.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of Promoter Elements Involved in Adaptive Regulation of the Taurine Transporter Gene: Role of Cytosolic Ca2+ Signaling

Han

Budreau

Chesney

2002

Advances in Experimental Medicine and Biology

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Identification of Promoter Elements Involved in Adaptive Regulation of the Taurine Transporter Gene: Role of Cytosolic Ca2+ Signaling

Han

Budreau

Chesney

2002

Advances in Experimental Medicine and Biology

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“…Surprisingly, taurine therapy mimics some of the actions of the ACE inhibitors. Takahashi et al (1997) and Rao and Tao (1998) have shown that treatment of rat cardiac cardiomyocytes with 20 mM taurine prevents angiotensin II-induced stimulation of [ 3 H]-phenylalanine incorporation. Moreover, taurine abolishes both angiotensin II-induced cell proliferation and the stimulation of [ 3 H]-thymidine uptake by rat cardiac nonmyocytes (primarily fibroblasts).…”

Section: Effect Of Taurine On Angiotensin Ii-induced Cell Proliferationmentioning

confidence: 99%

Interaction between the actions of taurine and angiotensin II

2000

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The amino acid, taurine, is an important nutrient found in very high concentration in excitable tissue. Cellular depletion of taurine has been linked to developmental defects, retinal damage, immunodeficiency, impaired cellular growth and the development of a cardiomyopathy. These findings have encouraged the use of taurine in infant formula, nutritional supplements and energy promoting drinks. Nonetheless, the use of taurine as a drug to treat specific diseases has been limited. One disease that responds favorably to taurine therapy is congestive heart failure. In this review, we discuss three mechanisms that might underlie the beneficial effect of taurine in heart failure. First, taurine promotes natriuresis and diuresis, presumably through its osmoregulatory activity in the kidney, its modulation of atrial natriuretic factor secretion and its putative regulation of vasopressin release. However, it remains to be determined whether taurine treatment promotes salt and water excretion in humans with heart failure. Second, taurine mediates a modest positive inotropic effect by regulating [Na+]i and Na+/Ca2+ exchanger flux. Although this effect of taurine has not been examined in human tissue, it is significant that it bypasses the major calcium transport defects found in the failing human heart. Third, taurine attenuates the actions of angiotensin II on Ca2+ transport, protein synthesis and angiotensin II signaling. Through this mechanism taurine would be expected to minimize many of the adverse actions of angiotensin II, including the induction of cardiac hypertrophy, volume overload and myocardial remodeling. Since the ACE inhibitors are the mainstay in the treatment of congestive heart failure, this action of taurine is probably very important.

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“…A long term effect of hypertension is the development of hypertrophy of the left ventricle, in which Angiotensin II (Ang II) plays an important role. Several studies have shown that taurine reverses these actions of Ang II [67,68]. Animal studies have also indicated that taurine may reduce insulin resistance [69,70], but most of the clinical studies have failed to prove the beneficial role of taurine in insulin resistance and diabetic complications [71,72].…”

Section: Taurine and Associated Health Benefitsmentioning

confidence: 99%

Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent

Eilertsen¹,

Larsen²,

Mæhre³

et al. 2012

Lipoproteins - Role in Health and Diseases

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Effects of Taurine on Signal Transduction Steps Induced during Hypertrophy of Rat Heart Myocytes

Cited by 14 publications

References 10 publications

Identification of Promoter Elements Involved in Adaptive Regulation of the Taurine Transporter Gene: Role of Cytosolic Ca2+ Signaling

Identification of Promoter Elements Involved in Adaptive Regulation of the Taurine Transporter Gene: Role of Cytosolic Ca2+ Signaling

Interaction between the actions of taurine and angiotensin II

Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent

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