Effects of taurine on reperfusion injury

Akdemır, Ovunc; Yan, Hede; Zhang, Feng; Lineaweaver, William C.; Arslan, Zikri; Songür, Ecmel

doi:10.1016/j.bjps.2010.12.007

Cited by 33 publications

(14 citation statements)

References 52 publications

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“…Treatment with Tau significantly decreased the MPO activity at 16 h, 48 h and 72 h PI suggesting that PMN infiltration and function are modulated by Tau. A similar result was observed by Akdemir et al (Akdemir et al 2011) regarding reperfusion injury in which the numbers of PMNs and amount of tissue necrosis in the Tau treatment group was significantly lower than the untreated control group.…”

Section: Discussionsupporting

confidence: 79%

Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells

et al. 2011

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Taurine (Tau) is reported to have a key role in the regulation of the innate immune response and thus reduce tissue damage induced by bacterial infection. In this study, the effects of Tau on a rat model of mastitis induced by Streptococcus uberis (S. uberis) and the changes of T regulatory cells (Tregs) were assessed. Starting on gestation day 14 and continuing until parturition, 100 mg/kg of taurine (group TS) or an equal volume of physiological saline (group CS) was administered daily, per os. Seventy-two hours after parturition, rats were infused with approximately 100 cfu of S. uberis into each of two mammary glands. The results showed that the resultant inflammation, evidenced by swelling, secretory epithelial cell degeneration, increased adipose tissue and neutrophil (PMN) infiltration were evident in mammary tissue following injection with S. uberis. Pre-treatment with Tau attenuated these morphologic changes, the expression of interleukin (IL)-2, interferon (INF)-γ mRNA, myeloperoxidase (MPO) activity and N-acetyl-β-D-glucosaminidase (NAGase) in mammary tissue. The percentages of Foxp3+CD25+CD4+/lymphocytes (Tregs) were dramatically increased after the S. uberis challenge. Significant differences (P<0.05) were observed at 24, and 72 h post S. uberis-injection (PI) in CS. Pre-treatment further increased the percentage of Tregs and a significant difference between CS and TS (P<0.05) was apparent at 24 h PI. Our data indicate that in rats, Tau can be used to regulate the immune response following infection by S. uberis and consequently prevent mammary tissue damage by increasing Tregs.

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Section: Discussionsupporting

confidence: 79%

Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells

et al. 2011

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“…The sections were painted with haematoxylin and examined under a high‐performance light microscope (×10, ×20 and ×100 magnifications) by two blinded examiners. According to modified Verhofstad scoring , the samples were examined based on the following seven parameters: neutrophil [polymorphonuclear granulocytes (PMN)], lymphocyte density, vascularity, fibroblast proliferation, the amount of oedema, collagen density and necrosis (Table ).…”

Section: Methodsmentioning

confidence: 82%

Comparison of skin effects of immediate treatment modalities in experimentally induced hydrofluoric acid skin burns

Songur

Akdemır

Lineaweaver

et al. 2014

International Wound Journal

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Hydrofluoric acid (HF) burns cause immediate damage and painful long-term sequellae. Traditionally, chelating agents have been used as the initial treatment for such burns. We have introduced epidermal growth factor (EGF) into an HF model to compare EGF with Ca(2+) and Mg(2+) treatments; 40 Sprague Dawley rats were divided into five groups. Each rat suffered a 6 × 4 cm(2) burn induced by 40% HF. Group 1 had no treatment, group 2 had saline injected beneath the burn, group 3 received magnesium sulphate injections, group 4 received calcium gluconate and group 5 received EGF. Specimens were evaluated via planimetry and biopsy at intervals of 4, 8, 24 and 72 hours. Fluid losses were significantly less in the Mg(2+) and EGF groups. The EGF group had the smallest burn area, least oedema, least polymorphonuclear granulocyte (PMN) infiltration, most angiogenesis and highest fibroblast proliferation of any group (P < 0·005). EGF limited HF damage morphologically and histologically more effectively than Ca(2+) or Mg(2+). This finding indicates that HF treatment via growth factors may be an improvement over chelation therapy.

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“…The flap was then placed in a drying oven and maintained for 24 hours at 65°C and the dry weight of the flap was measured with the same precision scale. The water content is calculated using the following formula [22]: Water content (%) = (Wet weight−Dry weight)/Wet weight × 100…”

Section: Methodsmentioning

confidence: 99%

The complicated role of venous drainage on the survival of arterialized venous flaps

et al. 2017

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The arterialized venous flap (AVF) has been gradually popularized in clinical settings; however, its survival is still inconsistent and the role of venous drainage remains elusive. In this study, we aimed to investigate the role of venous drainage on the flap survival of arterialized venous flaps. An arterialized venous flap was outlined symmetrically in the rabbit abdomen. The arterial perfusion flap with a unilateral vascular pedicle was taken as the control group and three other experimental groups (I, II and III) were designed based on the number of drainage veins (n = 1, 2 and 3 in the three groups, respectively). Compared with the control group, significant venous congestion was noted in all the experimental groups and the most severe one was seen in group I; while no statistical difference was observed between groups II and III. Similar results regarding blood perfusion state, epidermal metabolite levels and flap survival status were obtained among the three groups. These findings suggested that venous drainage is vital in the survival of the flap, but unlike in the arterial perfusion flaps, the problem of venous congestion can only be partially solved by increasing the number of draining veins. Further studies are warranted to gain insight into this complicated issue.

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Effects of taurine on reperfusion injury

Cited by 33 publications

References 52 publications

Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells

Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells

Comparison of skin effects of immediate treatment modalities in experimentally induced hydrofluoric acid skin burns

The complicated role of venous drainage on the survival of arterialized venous flaps

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