Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells

Miao, Jinfeng; Zhang, Jinqiu; Zheng, Liuhai; Yu, Xiaoming; Zhu, Wei; Zou, Shanmei

doi:10.1007/s00726-011-1047-3

Cited by 36 publications

(27 citation statements)

References 48 publications

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“…33, 34 Other evidence suggests that taurine may have a protective role by increasing T-regulatory cells which are known to protect against atherosclerosis. 35 Future studies should include examination of taurine levels in different tissues including plaques, and measuring the cytokine levels involved with T-cell activation and NF-kB pathways.…”

Section: Discussionmentioning

confidence: 99%

Effect of 9p21.3 Coronary Artery Disease Locus Neighboring Genes on Atherosclerosis in Mice

Kim¹,

deLuna²,

Mungrue³

et al. 2012

Circulation

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Background The human 9p21.3 chromosome locus has been shown to be an independent risk factor for atherosclerosis in multiple large scale genome-wide association studies, but the underlying mechanism remains unknown. We set out to investigate the potential role of the 9p21.3 locus neighboring genes, including Mtap, the two isoforms of Cdkn2a, p16Ink4a and p19Arf, and Cdkn2b in atherosclerosis using knockout mice models. Methods and Results Gene targeted mice for neighboring genes, including Mtap, Cdkn2a, p19Arf, and Cdkn2b, were each bred to mice carrying the human APO*E3 Leiden transgene which sensitizes the mice for atherosclerotic lesions through elevated plasma cholesterol. We found that the mice heterozygous for Mtap developed larger lesion compared to wild-type mice (49623±21650 vs. 18899±9604 μm2/section (Mean±SD); p=0.01), with similar morphology as wild type mice. The Mtap heterozygous mice demonstrated changes in metabolic and methylation profiles and CD4+ cell counts. The Cdkn2a knockout mice had smaller lesions compared to wild-type and heterozygous mice and there were no significant differences in lesion size in p19Arf and Cdkn2b mutants as compared to wild type. We observed extensive, tissue-specific compensatory regulation of the Cdkn2a and Cdkn2b genes among the various knockout mice, making the effects on atherosclerosis difficult to interpret. Conclusions Mtap plays a protective role against atherosclerosis, whereas Cdkn2a appears to be modestly proatherogenic. However, no relation was found between the 9p21 genotype and the transcription of 9p21 neighboring genes in primary human aortic vascular cells in vitro. There is extensive compensatory regulation in the highly conserved 9p21 orthologous region in mice.

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Section: Discussionmentioning

confidence: 99%

Effect of 9p21.3 Coronary Artery Disease Locus Neighboring Genes on Atherosclerosis in Mice

Kim¹,

deLuna²,

Mungrue³

et al. 2012

Circulation

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“…Additionally, inflammatory cell infiltration was more severe in the C groups than in the T groups. Numerous previous studies have reported that inflammatory cell infiltration is the first step in metabolic and inflammatory diseases (Grisham et al, 1986;Miao et al, 2012). Therefore, the oviducts of laying hens reared in a high-density environment could be protected from injury by taurine supplementation or by lowering the housing density.…”

Section: Discussionmentioning

confidence: 93%

Influence of dietary taurine and housing density on oviduct function in laying hens

Dai

Zhang

Zhi-gang

et al. 2015

J. Zhejiang Univ. Sci. B

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Experiments were conducted to study the effects of dietary taurine and housing density on oviduct function in laying hens. Green-shell laying hens were randomly assigned to a free range group and two caged groups, one with low-density and the other with high-density housing. Each group was further divided into control (C) and taurine treatment (T) groups. All hens were fed the same basic diet except that the T groups' diet was supplemented with 0.1% taurine. The experiment lasted 15 d. Survival rates, laying rates, daily feed consumption, and daily weight gain were recorded. Histological changes, inflammatory mediator levels, and oxidation and anti-oxidation levels were determined. The results show that dietary taurine supplementation and reduced housing density significantly attenuated pathophysiological changes in the oviduct. Nuclear factor-κB (NF-κB) DNA binding activity increased significantly in the high-density housing group compared with the two other housing groups and was reduced by taurine supplementation. Tumor necrosis factor-α (TNF-α) mRNA expression in the high-density and low-density C and T groups increased significantly. In the free range and low-density groups, dietary taurine significantly reduced the expression of TNF-α mRNA. Supplementation with taurine decreased interferon-γ (IFN-γ) mRNA expression significantly in the low-density groups. Interleukin 4 (IL-4) mRNA expression was significantly higher in caged hens. IL-10 mRNA expression was higher in the high-density C group than in the free range and low-density C groups. Supplementation with taurine decreased IL-10 mRNA expression significantly in the high-density group and increased superoxide dismutase (SOD) activity in the free range hens. We conclude that taurine has important protective effects against oviduct damage. Reducing housing density also results in less oxidative stress, less inflammatory cell infiltration, and lower levels of inflammatory mediators in the oviduct. Therefore, both dietary taurine and reduced housing density can ameliorate oviduct injury, enhance oviduct health, and promote egg production in laying hens.

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“…In the CNS it plays a role in: neuromodulation [55,56,57], osmoregulation [33,58], the maintenance of calcium homeostasis [59,60,61,62,63], membrane stabilization [64], anti-oxidation [65,66], anti-inflammation [67,68] and neuroprotection [59,69,70,71,72,73] and is also seen as a trophic factor during CNS development [40,74]. Its neuroprotective effect is observed against l -glutamate induced excitotoxicity whereby it counteracts the glutamate-induced increase of intracellular calcium through L-, P/Q-, N-type voltage-gated calcium channels (VGCCs) and the N -methyl- d -aspartate (NMDA) receptor, thus preventing glutamate-induce membrane depolarization [59,69].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Mechanisms of Taurine against Ischemic Stroke

Menzie

Prentice

2013

Brain Sciences

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Ischemic stroke exhibits a multiplicity of pathophysiological mechanisms. To address the diverse pathophysiological mechanisms observed in ischemic stroke investigators seek to find therapeutic strategies that are multifaceted in their action by either investigating multipotential compounds or by using a combination of compounds. Taurine, an endogenous amino acid, exhibits a plethora of physiological functions. It exhibits antioxidative properties, stabilizes membrane, functions as an osmoregulator, modulates ionic movements, reduces the level of pro-inflammators, regulates intracellular calcium concentration; all of which contributes to its neuroprotective effect. Data are accumulating that show the neuroprotective mechanisms of taurine against stroke pathophysiology. In this review, we describe the neuroprotective mechanisms employed by taurine against ischemic stroke and its use in clinical trial for ischemic stroke.

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Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells

Cited by 36 publications

References 48 publications

Effect of 9p21.3 Coronary Artery Disease Locus Neighboring Genes on Atherosclerosis in Mice

Effect of 9p21.3 Coronary Artery Disease Locus Neighboring Genes on Atherosclerosis in Mice

Influence of dietary taurine and housing density on oviduct function in laying hens

Neuroprotective Mechanisms of Taurine against Ischemic Stroke

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