Effects of taurine in glucose and taurine administration

Abstract

Taurine has several biological processes such as hypoglycemic action, antioxidation, detoxification, etc. To assess the effect of taurine administration on the guinea pigs with hyperglycemia, blood glucose, C-peptide levels together with morphologic alterations in the pancreatic ultrastructure were investigated in terms of hypoglycemic action and malondialdehyde and total sulfhydryl group levels with regard to oxidation-antioxidation relation. Animals were divided into four groups of six. Glucose supplementation group was administrated a single dose of glucose (400 mg/kg, i.p.) injection. Glucose and taurine supplementation group was administrated glucose treatment (a single dose, 400 mg/kg, i.p.) following taurine (a single dose, 200 mg/kg, i.p.). Taurine and glucose supplementation group was administered taurine treatment (a single dose, 200 mg/kg, i.p.) following glucose treatment (a single dose, 400 mg/kg, i.p.). Control animals received no treatment. Blood samples were collected at the end of the experiments for the determination of glucose, C-peptide (indicator of insulin secretion), lipid peroxidation (thiobarbituric acid reactive substances), and total sulfhydryl groups levels. Pancreatic tissue samples were then collected and processed for transmission electron microscopy. The findings showed that glucose supplementation following taurine administration significantly decreased blood glucose level by increasing C-peptide level and the pancreatic secretion stimulated morphologically and insignificantly changed thiobarbituric acid reactive substances and total sulfhydryl group levels. These observations suggest that taurine administration may be useful in hyperglycemia because of its hypoglycemic and protective effects.

Post-exercise taurine administration enhances glycogen repletion in tibialis anterior muscle

“…2B). This effect of taurine treatment is in agreement with some rodent studies that showed taurine administration attenuated the increase of blood glucose concentration during glucose tolerance testing [11][12][13][14][15][16][17] . In general, most glucose (>80%) is taken up by skeletal muscle 21) .…”

“…Glycogen repletion in skeletal muscle after exercise is one of the major determinants of performance during subsequent exercise since higher pre-exercise glycogen content in skeletal muscle resulted in improving performance during both prolonged endurance and high-intensity intermittent exercise [2][3][4][5] . Some rodent studies have shown the possibility that taurine administration enhances glucose uptake in tissues [11][12][13][14][15][16][17] , which is one of the limiting factors for glycogen synthesis in skeletal muscle. Therefore, we hypothesized that taurine administration enhanced postexercise glycogen repletion in skeletal muscle.…”

“…Although we should consider that there are possibilities that taurine admin- treatment is stimulation of insulin secretion. Some studies demonstrated that taurine administration improved glucose tolerance in rodents without altering the plasma insulin concentration 11,13) ; whereas others reported that taurine administration increased insulin secretion from islets 14,16,17) . In our experiment, no significant difference was observed in the plasma insulin concentration between the two groups ( Fig.…”

“…These results suggest that taurine administration has some positive effects during the post-exercise phase. Some rodent studies have demonstrated the possibility that taurine administration enhances glucose uptake, one of the rate-limiting factors for glycogen resynthesis in skeletal muscle [11][12][13][14][15][16][17] . Moreover, Kulakowski et al showed that a single dose of taurine was able to increase glycogen content in the liver at resting state in non-diabetic rats 11) .…”

Effects of taurine administration on exercise-induced fatigue and recovery

“…Thus, glycogen repletion in skeletal muscle after exercise should be a determinant for performance in subsequent exercise. Some rodent studies have reported that taurine administration enhances glucose uptake, which is a rate-limiting step for skeletal muscle glycogen re-synthesis [46][47][48][49][50][51] . Kulakowski et al showed that taurine administration increased incorporation of [ 3 H] deoxyglucose into skeletal muscle at the resting state in rats compared to a control group administered glucose only 46) .…”