Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages

Zhang, Xuemei; Xiong, Huanzhang; Li-ben, Liu

doi:10.1016/j.jep.2012.02.020

Cited by 90 publications

(52 citation statements)

References 39 publications

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“…and prevents LPS-induced nuclear factor κB (NF-κB) translocation from the cytoplasm to the nucleus. These results emphasize the anti-inflammatory effect of TS, as it was shown to block the NF-κB pathway that regulates protein-inflammatory gene expression [79]. Similarly to other medicinal plants (e.g.…”

Section: Anti-hyperglycemic Actionssupporting

confidence: 57%

“…It is also extracted from the flowers of Carthamus tinctorius, Chrysanthemum morifolium, and Helianthus annuus. According to Zhang et al (2012), TS has antiinflammatory properties, and is considered a therapeutic agent for the treatment of inflammatory diseases. It is known as a monohydroxy triterpene, which is found in burdock, arnica, and chicory, and which displays several biological activities [51].…”

Section: Taraxasterolmentioning

confidence: 99%

“…TS is a component of TO, and has anticarcinogenic and anti-tumor properties, as it was shown to cause a dose-dependent reduction in tumor cell viability by 26% [78]. Zhang et al (2012) showed that TS inhibits nitric oxide (NO), prostaglandin E 2 , TNF-α, IL-1β, and IL-6 in lipopolysaccharide-induced macrophages. and prevents LPS-induced nuclear factor κB (NF-κB) translocation from the cytoplasm to the nucleus.…”

Section: Anti-hyperglycemic Actionsmentioning

confidence: 99%

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The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes

2016

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■ AbstractThe tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential anti-diabetic properties. The Taraxacum genus from the Asteraceae family is found in the temperate zone of the Northern hemisphere. It is available in several areas around the world. In many countries, it is used as food and in some countries as therapeutics for the control and treatment of T2D. The anti-diabetic properties of dandelion are attributed to bioactive chemical components; these include chicoric acid, taraxasterol (TS), chlorogenic acid, and sesquiterpene lactones. Studies have outlined the useful pharmacological profile of dandelion for the treatment of an array of diseases, although little attention has been paid to the effects of its bioactive components on T2D to date. This review recapitulates previous work on dandelion and its potential for the treatment and prevention of T2D, highlighting its anti-diabetic properties, the structures of its chemical components, and their potential mechanisms of action in T2D. Although initial research appears promising, data on the cellular impact of dandelion are limited, necessitating further work on clonal β-cell lines (INS-1E), α-cell lines, and human skeletal cell lines for better identification of the active components that could be of use in the control and treatment of T2D. In fact, extensive invitro, in-vivo, and clinical research is required to investigate further the pharmacological, physiological, and biochemical mechanisms underlying the effects of dandelion-derived compounds on T2D.

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Section: Anti-hyperglycemic Actionssupporting

confidence: 57%

Section: Taraxasterolmentioning

confidence: 99%

Section: Anti-hyperglycemic Actionsmentioning

confidence: 99%

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The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes

2016

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“…En effet, plusieurs auteurs ont déjà rapporté ses propriétés antitumorale (Jamshieed et al, 2010), anti-allergique (Liu et al, 2013), antioxydante (Gallová et al, 2007) et anti-inflammatoire (Zhang et al, 2012). Ovesna et al (2004) ont enregistré expérimentalement l'inhibition du développement du cancer du côlon et du sein par le taraxastérol et le β-sitostérol.…”

Section: Importance Pharmacologique Des Composés Identifiésunclassified

Identification de deux phytostérols biologiquement actifs de l’extrait cyclohexanique des feuilles de <i>Ficus sur</i> (Moraceae)

Boyode¹,

Simalou²,

Eloh³

et al. 2018

Int. J. Bio. Chem. Sci

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Tel. : (+228) 91 58 81 61 REMERCIEMENTS Nos sincères remerciements vont à l'Agence Universitaire de la Francophonie (AUF) pour le financement de ce travail. RESUMEFicus sur est une plante alimentaire couramment utilisée en médecine traditionnelle au Togo. Elle a cependant fait l'objet de très peu d'études phytochimiques. Le présent travail a pour but de valoriser cette espèce à travers l'identification continue de ses métabolites. Ainsi, l'extraction cyclohexanique au Soxhlet a été réalisée sur les feuilles de Ficus sur. Cet extrait cyclohexanique obtenu a été ensuite fractionné puis purifié par chromatographie sur colonne de gel de silice. L'identification des composés a été réalisée par GC-MS, précédée quelquefois d'une étape de dérivatisation. Treize fractions (A1 à A13) ont été obtenues du fractionnement de cet extrait. Après deux purifications successives de la fraction A5, deux sous-fractions A5. Identification of two bioactive phytosterols of the cyclohexane extract of Ficus sur (moraceae) leaves ABSTRACTFicus sur is a food plant commonly used in traditional medicine in Togo. However, few phytochemical studies of this species are available. This work aims at contributing to the enhancement of this approach through an identification of its metabolites. The leaves of Ficus sur were then extracted with cyclohexane using soxhlet. The obtained cyclohexane extract was fractionated and purified by chromatography on silica gel column. Identification of the compounds was carried out by GC-MS, sometimes preceded by a derivatization step. Thirteen fractions (A1 to A13) were obtained from the fractionation of this extract. After two successive purifications of the fraction A5, two subfractions A5.1 and A5.2 were obtained. The mass spectrum of a compound of A2 has a molecular peak at m/z 426 and peaks [M-69]

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“…Inflammation is the first response of the immune system to irritation or infection caused by numerous stimuli and the normal result of host protective response to tissue injury; it often shows as redness, swelling, pain and dysfunction of tissues and organs (Ialenti et al, 1993;Zhang et al, 2012). On the one hand, inflammation initiates the healing process and eliminates invading pathogens.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Anti-Inflammatory Effects of Taraxasterol Against Animal Models

Wang

Liu

et al. 2016

AJTCAM

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Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages

Cited by 90 publications

References 39 publications

The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes

The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes

Identification de deux phytostérols biologiquement actifs de l’extrait cyclohexanique des feuilles de <i>Ficus sur</i> (Moraceae)

In Vivo Anti-Inflammatory Effects of Taraxasterol Against Animal Models

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