In Vivo Anti-Inflammatory Effects of Taraxasterol Against Animal Models

Wang, Ying; Li, Guanhao; Liu, Xinyu; Xu, Lu; Wang, Shasha; Zhang, Xuemei

doi:10.21010/ajtcam.v14i1.6

Cited by 14 publications

(7 citation statements)

References 27 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Herba Taraxaci Mongolici, Flos Carthami, and Semen Coicis are related to inflammatory index, such as ESR and CRP. The new research demonstrated that taraxasterol has the in vitro anti-inflammatory effect, which is one of the chief active components isolated from Herba Taraxaci Mongolici [ 21 ]. Flos Carthami [ 22 ] and Semen Coicis [ 23 ] are perhaps connected to its antioxidation and anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Zhou

Liu

Xin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Osteoarthritis (OA) is a degressive and complex disease which is a growing public health problem on a global scale. On basis of an in-house database consisting of clinical records of 13,083 OA patients, the Traditional Chinese Medicine (TCM) was divided into 4 categories of medicines on the basis of the curative properties of herbs. Due to the lack of depth and internal relationship in the calculation results of TCM compatibility law data mining methods such as statistics and frequency analysis, we use a variety of multidimensional complex network methods that can efficaciously find the compatibility law of TCM, including similarity measure, graphical visualization of network diagram, random walking, and propensity score methods. We summarize common couplet medicines utilized for the treatment of osteoarthritis. The similarity measure method was used to investigate the commonly used drugs for the treatment of osteoarthritis. The method of association rule analysis is used to recognize the compatibility between the components. On basis of the propensity score methods, the evaluation displayed that, compared with single drug, the drug group increased ESR, CRP, C3, C4, IgG, and IgA more efficiently. Concluding, a random walk model was constructed to assess drug efficacy. After applying a random walk model, while revealing the compatibility among different components of TCM, their therapeutic efficacy against OA is analyzed. We obtained four groups of drug combination clusters by similarity measure and 11 pairs of highly connected drugs by association rules, which are cardinal drug combinations in the prescription for the treatment of OA. We also found that different traditional drug pairs were associated with different laboratory indexes, and drug combinations could better optimize laboratory indexes. This study presented that the TCM constituents complement one another. Besides, the therapeutic effects resulting from a variety of combinations of these constituents are quite different.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Zhou

Liu

Xin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In this study, ethanol increased TNF- α and IL-6 secretion, and taxarasterol significantly reduced ethanol-induced TNF- α and IL-6 secretion, indicating that taraxasterol could protect ethanol-induced liver injury by involving antagonism of proinflammatory cytokines. Many of our previous studies have also shown that taraxasterol has the in vitro and in vivo anti-inflammatory activity by suppressing the production of various inflammatory cytokines and mediators [ 15 , 17 – 19 , 34 ]. The present data are consistent with our previous studies.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Taraxasterol against Ethanol‐Induced Liver Injury by Regulating CYP2E1/Nrf2/HO‐1 and NF‐κB Signaling Pathways in Mice

Sang

et al. 2018

Oxidative Medicine and Cellular Longevity

Self Cite

153

View full text Add to dashboard Cite

Taraxasterol, a pentacyclic-triterpene compound, is one of the main active components isolated from the traditional Chinese medicinal herb Taraxacum. The objective of this study is to evaluate the protective effects of taraxasterol and its possible underlying mechanisms against ethanol-induced liver injury in mice. ICR mice were fed with Lieber-DeCarli diet containing 5% ethanol for 10 d and then challenged with a single dose of 20% ethanol (5 g/kg BW) by intragastric administration. The mice were intragastrically treated daily with taraxasterol (2.5, 5, and 10 mg/kg). Tiopronin was used as a positive control. The liver index was calculated, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in sera were detected. The contents of reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione (GSH) and the activity of superoxide dismutase (SOD) in the livers were measured. The histopathological changes of liver tissues were observed by hematoxylin and eosin (H&E) staining. The protein expression levels of hepatic cytochrome P450 2E1 (CYP2E1), nuclear factor erythroid 2-related factor 2 (Nrf2), antioxidant protein heme oxygenase-1 (HO-1), and nuclear factor-kappa B (NF-κB) signaling pathway in liver tissues were detected by immunohistochemistry and Western blot methods. Taraxasterol significantly reduced the ethanol-induced increases of liver index, ALT, AST, and TG levels in sera and TG and MDA contents in the livers and hepatic ROS production and suppressed the ethanol-induced decreases of hepatic GSH level and SOD activity. Taraxasterol also significantly inhibited the secretion of proinflammatory cytokines TNF-α and IL-6 induced by ethanol. In addition, taraxasterol improved the liver histopathological changes in mice with ethanol-induced liver injury. Further studies revealed that taraxasterol significantly inhibited the ethanol-induced upregulation of CYP2E1, increased the ethanol-induced downregulation of Nrf2 and HO-1, and inhibited the degradation of inhibitory kappa Bα (IκBα) and the expression level of NF-κB p65 in liver tissues of ethanol-induced mice. These findings suggest that taraxasterol possesses the potential protective effects against ethanol-induced liver injury in mice by exerting antioxidative stress and anti-inflammatory response via CYP2E1/Nrf2/HO-1 and NF-κB signaling pathways.

show abstract

“… 73 After sacrifice, the weight of granuloma, the expression of inflammatory mediators (proinflammatory cytokines, NO and so on) and the level of ROS related indexes are assessed to evaluate anti‐inflammatory activity. The anti‐inflammatory effect of Taraxacum officinale , 83 Ipomoea stolonifera 73 and Qingdaisan (Formulated Indigo powder) 84 has been confirmed in a cotton pellet‐induced granuloma model. Thus, granuloma is a widely used model for the assessment of chronic anti‐inflammatory activity of TCM.…”

Section: The Classical Experimental Model Of the Anti‐inflammatory Ef...mentioning

confidence: 89%

Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Hou

Guo

et al. 2022

Anim Models and Exp Med

View full text Add to dashboard Cite

Inflammation is a common disease involved in the pathogenesis, complications, and sequelae of a large number of related diseases, and therefore considerable research has been directed toward developing anti‐inflammatory drugs for the prevention and treatment of these diseases. Traditional Chinese medicine (TCM) has been used to treat inflammatory and related diseases since ancient times. According to the review of abundant modern scientific researches, it is suggested that TCM exhibit anti‐inflammatory effects at different levels, and via multiple pathways with various targets, and recently a series of in vitro and in vivo anti‐inflammatory models have been developed for anti‐inflammation research in TCM. Currently, the reported classic mechanisms of TCM and experimental models of its anti‐inflammatory effects provide reference points and guidance for further research and development of TCM. Importantly, the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation‐related diseases.

show abstract

In Vivo Anti-Inflammatory Effects of Taraxasterol Against Animal Models

Abstract: contributed equally to this study. AbstractBackground: Traditional Chinese medicine Taraxacum officinale has been widely used to treat various inflammatory diseases.

Cited by 14 publications

References 27 publications

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Protective Effects of Taraxasterol against Ethanol‐Induced Liver Injury by Regulating CYP2E1/Nrf2/HO‐1 and NF‐κB Signaling Pathways in Mice

Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Contact Info

Product

Resources

About