Effects of Tamsulosin on Bladder Blood Flow and Bladder Function in Rats With Bladder Outlet Obstruction

Effect of a single treatment with tadalafil on blood flow in lower urinary tract tissues in rat models of bladder overdistension/emptying and abdominal aorta clamping/release

“…In this model, we found that intraduodenal administration of tadalafil significantly blocked the progressive O/ E-induced reduction in BBF. Decreased BBF has been reported in BPH patients (Mitterberger Q5 et al, 2007) and animals with partial urethral obstruction (Greenland et al, 2000;Lin et al, 1995;Okutsu et al, 2010). These findings indicate that bladder ischemia is a key mechanism underlying symptoms that are associated with BPH.…”

“…In addition, in the aorta C/R model, it is difficult to relate the clamping of the abdominal aorta to the reduced blood flow in BPH patients. Other reports have shown that blood flow is impaired both in the bladder in animal BOO models (Greenland et al, 2000;Lin et al, 1995;Okutsu et al, 2010) and in the bladder and prostate in BPH patients (Pinggera et al, 2008a(Pinggera et al, , 2008b. However, the magnitude of the blood-flow impairment has not been compared in the animal models and BPH patients.…”

Effects of Chronic Treatment With Cilostazol, a Phosphodiesterase 3 Inhibitor, on Female Rat Bladder in a Partial Bladder Outlet Obstruction Model

“…Increasing evidence has shown that ischemia and reperfusion are major etiologic factors in the progression of bladder dysfunction induced by BOO, and that part of the damage is due to the generation of free radicals and the resultant cellular and subcellular membrane peroxidation [1]. The importance of ischemia as an etiologic factor in bladder dysfunction has been supported by recent animal studies in which bladder ischemia was experimentally created by BOO, bladder overdistension and atherosclerosis [2][3][4][5][6][7]. The evidence has suggested that bladder ischemia causes significant bladder dysfunction and leads to decreased contractile responses of the bladder.…”

“…The evidence has suggested that bladder ischemia causes significant bladder dysfunction and leads to decreased contractile responses of the bladder.  1 -blocker has been shown to have a protective effect on bladder function of the rat after BOO or bladder overdistension possibly through an improvement of bladder ischemia [6,7]. In clinical practice, 1 -blocker is widely used as a first-line treatment for male patients with LUTS that are associated with BOO due to BPH (LUTS/BPH).…”

Androgen Deficiency and Progression of Benign Prostatic Hyperplasia in Patients With Metabolic Syndrome: Is There Any Controversy? (A Literature Review)

“…Доказательства развития хронической ишемии гипер-плазированной ПЖ представлены в многочисленных исследованиях [9,40,41]. При этом у больных с артери-альной гипертонией и гипергликемией, являющимися И ГЕНИТАЛЬНАЯ ХИРУРГИЯ ТОМ 18 / VOL.…”