Effects of synthetic progestagens on drug metabolism in rat liver musomes

Tüttenberg, Klaus H.; Hüthwohl, B; Kahl, Regine; Kahl, Georg F.

doi:10.1016/0006-2952(74)90262-7

Cited by 14 publications

(2 citation statements)

References 14 publications

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“…We were unable to detect any decrease in the activity of the liver microsomal enzymes after combined contraceptive treatments in mice and rats. The inhibition of drug metabolism by the progestogens was generally found in experiments in vitro and at very high concentrations (Soyka & Long, 1972;Tuttenberg et al, 1974). In vivo only norethynodrel has been reported to inhibit pentobarbitone metabolism (Juchau & Fouts, 1966;Jori et al, 1969), after a single acute treatment.…”

Section: Discussionmentioning

confidence: 95%

Effects of Contraceptive Agents on Drug Metabolism in Various Animal Species

Briatico

Guiso

Jori

et al. 1976

British J Pharmacology

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I The effect on liver microsomal enzyme activity of three steroid contraceptive drug (SCD) combinations was compared in rats, mice and guinea-pigs. Lynestrenol plus mestranol, norethisterone plus mestranol and norethynodrel plus mestranol were given orally for 4 consecutive days (acute treatment) or 30 days (chronic treatment) at various doses eliciting an experimentally controlled antifertility activity which varied in its extent. 2 In rats and mice all the combined treatments (with the exception of norethynodrel plus mestranol in mice) were active as inducers of liver microsomal enzymes. This induction seems to be mediated mainly by the progestogenic compounds. Oestrogens showed a very poor effect bordering on significance only in a few cases. 3 No effect on liver microsomal protein or cytochrome P 450 concentration was obtained after treatment with doses capable of increasing the microsomal enzyme activity. 4 The activity of the liver microsomal enzymes did not appear to be reduced immediately (2 h) after the last administration of the SCD given during 4 or 30 days. 5Contraceptive treatments at doses capable of eliciting complete antifertility activity were inactive on liver microsomal enzyme activity in guinea-pigs.

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Section: Discussionmentioning

confidence: 95%

Effects of Contraceptive Agents on Drug Metabolism in Various Animal Species

Briatico

Guiso

Jori

et al. 1976

British J Pharmacology

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“…Numerous reports indicate that steroid inactivation in the endoplasmic reticulum of hepatocytes is carried out b y the same enzyme system responsible for the oxidation of foreign compounds (Tuttenberg et al 1974). Interactions between steroids a n d d r u g metabolism have been extensively described (Sotaniemi et al 1973;Nishino 1975).…”

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confidence: 99%

Effect of Androgens on Antipyrine Metabolism in the Rabbit

et al. 1978

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The inactivation of endogenous steroids and foreign compounds by the liver hydroxylative pathway, can be modified by androgenic substances. The inhibitory or inductory activity, can be estimated by measuring the half‐life of antipyrine. Androgens (testosterone propionate, 5α‐dihydro‐testosterone and mesterolone) reduce antipyrine metabolism in male rabbits. In females, androgens are not inhibitors, but one of them, 5α‐dihydrotestosterone, shows an inductive effect on liver oxidative mechanisms.

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Evidence for endogenous triggering of perinatal inducibility of hepatic monooxygenase

Schubert

Netter

1981

Biochemical Pharmacology

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Effects of synthetic progestagens on drug metabolism in rat liver musomes

Cited by 14 publications

References 14 publications

Effects of Contraceptive Agents on Drug Metabolism in Various Animal Species

Effects of Contraceptive Agents on Drug Metabolism in Various Animal Species

Effect of Androgens on Antipyrine Metabolism in the Rabbit

Evidence for endogenous triggering of perinatal inducibility of hepatic monooxygenase

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