Evidence for endogenous triggering of perinatal inducibility of hepatic monooxygenase

Schubert, Ingrid; Netter, K.J.

doi:10.1016/0006-2952(81)90250-1

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…It has been established that drugmetabolizing enzymes have low activities in fetal rat liver. Several studies have been concerned with the development of these enzymes in rat liver during the perinatal period and also in aging [9][10][11]. In addition, the effect of several inducers during these periods has been studied [12,13].…”

Section: Introductionmentioning

confidence: 99%

Ontogeny of Benzo(a)pyrene Hydroxylase, Epoxide Hydrolase and Glutathione-S Transferase in the Brain, Lung and Liver of C57B1/6 Mice

Rouet¹,

Dansette²,

Frayssinet³

1984

Dev Pharmacol Ther

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Typical developmental patterns of three drug-metabolizing enzymes in C57B1/6 mouse brain, lung and liver could be divided into three stages: stage I, at the end of intrauterine life, where an increase in enzymatic activity was observed; stage II. during the first days after birth, where a decrease was seen; and stage III from the 6th day until weaning, where there was a gradual increase, reaching the same values as in the adult animal. However, pulmonary benzo(a)pyrene hydroxylase activity showed an abrupt burst starting on day 6 of postnatal life, then decreased slowly to become steady, and finally increased again. Our data show that the major metabolic pathways catalyzed by gluta- thione-S transferase and epoxide hydrolase are operative in mouse fetal brain and lung, just as in liver. In addition, we show that enzymatic systems are inducible during fetal life by exogenous compounds such as 5,6-benzoflavone. The early developmental evolution of the drug-metabolizing enzymes should help understand feto-toxicological and teratological phenomena.

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Section: Introductionmentioning

confidence: 99%

Ontogeny of Benzo(a)pyrene Hydroxylase, Epoxide Hydrolase and Glutathione-S Transferase in the Brain, Lung and Liver of C57B1/6 Mice

Rouet¹,

Dansette²,

Frayssinet³

1984

Dev Pharmacol Ther

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“…However, enzyme activity did not necessarily correlate with mRNA expression and, similar to the present findings, was always lower at PND1 than at any subsequent age. 19 Some investigators suggest that hormones in the maternal circulation, such as progesterone, are responsible for the low activity of phase I drug-metabolizing enzymes during the perinatal period, 24,25 while the rapid postnatal increases in enzyme activity are driven by the onset of pituitary released growth hormone. 23,26…”

Section: Age-dependent Changes In Cyp Activitymentioning

confidence: 99%

Effects in Rats of Maternal Exposure to Raspberry Leaf and Its Constituents on the Activity of Cytochrome P450 Enzymes in the Offspring

Makaji

Holloway

et al. 2010

Int J Toxicol

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The goal of our study was to determine whether maternal exposure to red raspberry leaf (RRL) and its constituents can permanently alter biotransformation of fluorogenic substrates by cytochrome P450 (CYP) in the livers of male and female offspring. Nulliparous female rats received vehicle, raspberry leaf, kaempferol, quercetin, or ellagic acid orally once breeding had been confirmed until parturition. Hepatic microsomes were prepared from animals at birth (postnatal day 1 [PND1]), weaning (PND21), PND65, and PND120 to determine the biotransformation of 8 fluorogenic substrates. The pattern of biotransformation of all but 2 of the substrates was gender specific. Maternal consumption of RRL increased biotransformation of 3 substrates by female offspring at PND120 resulting in a more masculine profile. Kaempferol and quercetin had a similar effect to RRL. These results suggest that maternal consumption of either RRL or some of its constituents leads to long-term alterations of CYP activity in female offspring.

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Regulation of drug‐metabolizing enzymes during the perinatal period in rat and human liver

Cresteil

1987

BioEssays

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The importance of drug‐metabolizing enzymes in developing mammals has been recently reevaluated in view of the activities and potential inducibilities of these enzymes. The role of endogenous factors raises the question of whether there is a positive regulation of the expression of drug‐metabolizing enzymes by hormones. In humans, among the different isoenzymes of cytochrome P‐450 described in adult liver, only one is absent in 20‐week‐old fetuses. Epoxide hydrolase and glutathione S‐transferases are active while UDP‐glucuronidation develops postnatally. The consequence of this asynchronous rise of activities is briefly discussed.

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Evidence for endogenous triggering of perinatal inducibility of hepatic monooxygenase

Cited by 8 publications

References 17 publications

Ontogeny of Benzo(a)pyrene Hydroxylase, Epoxide Hydrolase and Glutathione-S Transferase in the Brain, Lung and Liver of C57B1/6 Mice

Ontogeny of Benzo(a)pyrene Hydroxylase, Epoxide Hydrolase and Glutathione-S Transferase in the Brain, Lung and Liver of C57B1/6 Mice

Effects in Rats of Maternal Exposure to Raspberry Leaf and Its Constituents on the Activity of Cytochrome P450 Enzymes in the Offspring

Regulation of drug‐metabolizing enzymes during the perinatal period in rat and human liver

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