Effects of synthesis conditions on the morphology of hydroxyapatite nanoparticles produced by wet chemical process

Wang, Peipei; Li, Caihong; Gong, Hongyu; Jiang, Xuerong; Wang, Hongqiang; Li, Kaixing

doi:10.1016/j.powtec.2010.05.023

Cited by 260 publications

(131 citation statements)

References 28 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…3. The sample exhibited absorption bands due to hydroxyl stretch at *3500 cm -1 (Wang et al 2010). A previous study shows that the hydroxyl group decreases when carbonate content increases (Rehman and Bonfield 1997).…”

Section: Atr-ftirmentioning

confidence: 82%

“…The spectrum shows the characteristic of nHA where the intense peak of 1021 cm -1 was associated with PO 4 3-antisymmetric stretching mode (Paz et al 2012). The 961 cm -1 peak corresponds to the PO 4 3--derived bands (Wang et al 2010). The peak between 1420 and 1427 cm -1 shown in spectrum, at 1348 cm -1 and another peak at 826 cm -1 , are related to carbonated apatite.…”

Section: Atr-ftirmentioning

confidence: 86%

See 1 more Smart Citation

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

Hassan

Sultana

2017

3 Biotech

View full text Add to dashboard Cite

Considering the important factor of bioactive nanohydoxyapatite (nHA) to enhance osteoconductivity or bone-bonding capacity, nHA was incorporated into an electrospun polycaprolactone (PCL) membrane using electrospinning techniques. The viscosity of the PCL and nHA/PCL with different concentrations of nHA was measured and the morphology of the electrospun membranes was compared using a field emission scanning electron microscopy. The water contact angle of the nanofiber determined the wettability of the membranes of different concentrations. The surface roughness of the electrospun nanofibers fabricated from pure PCL and nHA/PCL was determined and compared using atomic force microscopy. Attenuated total reflectance Fourier transform infrared spectroscopy was used to study the chemical bonding of the composite electrospun nanofibers. Beadless nanofibers were achieved after the incorporation of nHA with a diameter of 200-700 nm. Results showed that the fiber diameter and the surface roughness of electrospun nanofibers were significantly increased after the incorporation of nHA. In contrast, the water contact angle (132°± 3.5°) was reduced for PCL membrane after addition of 10% (w/ w) nHA (112°± 3.0°). Ultimate tensile strengths of PCL membrane and 10% (w/w) nHA/PCL membrane were 25.02 ± 2.3 and 18.5 ± 4.4 MPa. A model drug tetracycline hydrochloride was successfully loaded in the membrane and the membrane demonstrated good antibacterial effects against the growth of bacteria by showing inhibition zone for E. coli (2.53 ± 0.06 cm) and B. cereus (2.87 ± 0.06 cm).

show abstract

Section: Atr-ftirmentioning

confidence: 82%

Section: Atr-ftirmentioning

confidence: 86%

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

Hassan

Sultana

2017

3 Biotech

View full text Add to dashboard Cite

show abstract

“…Nanoparticles with several morphologies have been synthesized by means of solid-state reaction, the emulsion technique, sol-gel and the hydrothermal method. [6][7][8][9][10][11] However, the wet chemical precipitation method was proven to be one of the easiest ways of preparing HAn powders. Akao et al 10 prepared HAn nanocrystals based on the following reaction of calcium hydroxide (Ca(OH) 2 ) with orthophosphoric acid (H 3 PO 4 ):…”

Section: Introductionmentioning

confidence: 99%

“…11 Another interesting and low-cost method of synthesis is by preparing HAn in metastable synthetic body fluid (SBF) under "biomimetic" conditions (37 o C and pH 7.4). Tas et al 12 reported the formation of HAn by the biomimetic method in 24 h, with controlled morphology and a high degree of phase purity.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of hydroxyapatite nanoparticles synthesized by different routes

Paz¹,

Guadarrama²,

López³

et al. 2012

Quím. Nova

View full text Add to dashboard Cite

In this study, bioactive hydroxyapatite nanoparticles were prepared by two different methods: wet chemical precipitation and biomimetic precipitation. The aim was to evaluate the morphology, particle-size, crystallinity and phases of the powders obtained by traditional wet chemical precipitation and the novel biomimetic precipitation using a supersaturated calcium solution. The nanoparticles were investigated by transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. The results revealed that the nanoparticles were formed by hydroxyapatite with a high crystallinity and controlled morphology. Additionally, it was found that the shape and size of the nanoparticles can be modified with each preparation method.

show abstract

“…The experimental involve additional of desired amount of 0.67 M of ortho-phosphoric acid (Merck, 85%) to desired amount of 1 M calcium hydroxide (Merck). The chemical equation involve is: 10Ca(OH) 2 + 6H 3 PO 4 Ca 10 (PO 4 ) 6 …”

Section: Materials and Methods Precipitationmentioning

confidence: 99%

Synthesis and Characterization of Hydroxyapatite Nanoparticle

Rafie

Nordin²

2017

MJAS

View full text Add to dashboard Cite

In this research, hydroxyapatite (HA) nano-size powder was synthesized using wet chemical precipitation technique under atmospheric pressure where calcium hydroxide (Ca(OH) 2 ) and ortho-phosphoric acid (H 3 PO 4 ) were used as precursors. Distilled water was used as a diluting media for the reaction and sodium hydroxide (NaOH) was used to control the initial pH. The initial pH values, reaction temperature and calcined temperature play an important role in the morphology on HA as well as the phase formation and degree of crystallinity. Nano HA powder has been studied at different initial pH value which is between 9.00 to 11.00, reaction temperature from 80 °C to 100 °C and calcined temperature at 700 °C to 800 °C. The optimum initial pH value was found at pH 10.00, reaction temperature at 100 °C and calcined temperature was at 800 °C. The crystallographic properties were evaluated by X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) and Field Emission Scanning Microscope (FESEM). The Design Expert version 9.0.2 with statistical and graphical analysis of the result, by using analysis of variance (ANOVA) was applied to optimize variable in the process of synthesis of HA. Based on analysis of variance (ANOVA) that has been perform, calcined temperature was to be influential variables on mass of HA with value of probability less than 0.05. Keywords: hydroxyapatite, chemical precipitation, crystallinity, morphology, optimization AbstrakDalam kajian ini, nanozarah hidroksiapatit (HA) dihasilkan melalui kaedah pemendakan di bawah tekanan atmosfera di mana kalsium hidroksida (Ca(OH) 2 ) dan asid orto fosforik (H 3 PO 4 ) merupakan larutan asas bagi penyediaan HA. Air suling digunakan sebagai agen pelarut dalam menyediakan larutan asas bagi proses pemendakan ini. Larutan natrium hidroksida di gunakan bagi mengawal nilai pH. Nilai pH, suhu tindak balas dan suhu relau merupakan faktor penting dalam pencirian dan penghabluran nanozarah HA. Nanozarah HA disediakan pada nilai pH antara 9.00 hingga 11.00, suhu tindak balas 80 °C hingga 100 °C dan suhu relau pada 700 °C hingga 800 °C. Pencirian nanozarah HA di uji menggunakan X-ray Difractometer (XRD), Inframerah Transformasi Fourier (FTIR), dan Mikroskop Pengimbas Pancaran Medan (FESEM). Perisian Design-Expert 9.0.2 digunakan untuk menganalisis data dan pengoptimuman penghasilan mendakan HA. Berdasarkan analisis varian (ANOVA) yang dilakukan, suhu relau merupakan pemboleh ubah yang mempengaruhi berat HA dengan nilai kemungkinan kurang dari 0.05.Kata kunci: hikdroksiapatit, mendakan bahan kimia, penghabluran, pencirian, pengoptimuman IntroductionTissue disease and defect, and bone disease are serious health condition that can affect the life for those who suffer on it. Since last four decades, various revolution has been introduced in order to make improvement of the uses of

show abstract

Effects of synthesis conditions on the morphology of hydroxyapatite nanoparticles produced by wet chemical process

Cited by 260 publications

References 28 publications

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

A comparative study of hydroxyapatite nanoparticles synthesized by different routes

Synthesis and Characterization of Hydroxyapatite Nanoparticle

Contact Info

Product

Resources

About