Effects of synbiotic on the intestinal morphology and humoral immune response in broiler chickens

Hassanpour, Hossein; Moghaddam, A. K. Zamani; Khosravi, Mohammad; Mayahi, M

doi:10.1016/j.livsci.2013.02.004

Cited by 51 publications

(61 citation statements)

References 23 publications

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“…Hassanpour et al (9) in a synbiotic group in the jejunum (after 42 days) found decreased width of the villi, which differs from our study. After Bacillus subtilis supplementation, significant higher villus height and crypt depth were noted in the jejunum in Pelicano et al 's (8) research.…”

Section: Discussioncontrasting

confidence: 99%

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Effect of Effective Microorganisms on intestinal morphology and morphometry in Japanese quails

Gesek¹,

Sokół²,

Lambert³

et al. 2018

Turk J Vet Anim Sci

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The aim of this study was to determine the effect of supplementation with Effective Microorganisms (EM) on the morphology and the morphometry of the intestine, and on proliferation activity of crypt cells in Japanese quails. The EM group (16 birds) received EM for 30 days in water (3 L/1000 L of water) and in feed (5 kg/1000 kg of feed) mixed with standard diet. The second group (16 birds) was established as the control group (no EM supplementation). Histopathological analysis revealed infiltration of lymphoid cells mainly in the duodenum and jejunum similarly in the EM and the control groups. The EM group showed irregular villus surfaces when compared to the control group. Morphometric analysis revealed significant differences in the EM group for villus width in the duodenum (186.0 µm to 170.7 µm; P ≤ 0.05), in crypt depth (129.2 µm to 110.7 µm; P ≤ 0.05), muscular layer thickness in the jejunum (70.88 µm to 57.44 µm) (P ≤ 0.05), and muscular layer thickness in the ileum (76.88 µm to 64.76 µm; P ≤ 0.05). Immunohistochemical analysis of proliferating cell nuclear antigen activity was similar for the EM and the control groups: in the duodenum 90.82% in the control group and 91.89% in the EM group, in the jejunum 93.32% in the control group and 94.53% in the EM group, and in the ileum 92.53% in the control group and 93.92% in the EM group. Supplementation with EM resulted in improved structure and functions of the villi and changed their surface, height, width, and crypt depth.

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Section: Discussioncontrasting

confidence: 99%

“…Administration of synbiotics has been shown to increase final body weight (9) and had positive effects on intestinal morphology and morphometry (10). Yeast products as growth promoters have also been of interest to poultry researchers.…”

mentioning

confidence: 99%

Effect of Effective Microorganisms on intestinal morphology and morphometry in Japanese quails

Gesek¹,

Sokół²,

Lambert³

et al. 2018

Turk J Vet Anim Sci

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“…Hassanpour et al. () also indicated that 0.1% synbiotic had positive effect on intestinal morphology. Our study agrees with the above reports.…”

Section: Discussionmentioning

confidence: 93%

Effects of dietary supplementation of synbiotics on growth performance, intestinal morphology, sIgA content and antioxidant capacities of broilers

Min

Yang

et al. 2016

Animal Physiology Nutrition

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Today, several strategies are being used to decrease the serious effects of antibiotics abuse on broilers industry and public health, among which synbiotics are one of the most promising antibiotic alternative. This study was undertaken to assess the effects of synbiotics, which composed of probiotics (Bacillus subtilis) and prebiotics (xylooligosaccharide and mannanoligosaccharide), on growth performance, intestinal morphology, sIgA content and antioxidant parameters of broilers. Four hundred and fifty one-day-old commercial Cobb48 broilers were assigned to five treatments consisting of six replicates of 15 birds each pen. Five dietary treatments include basal diets (control), basal diets plus antibiotics (4 mg/kg Xanthomycin), basal diets plus 1 g of probiotics B. subtilis product/kg of diets (4 × 10 cfu/kg), basal diets plus 150 mg/kg xylooligosaccharide (35%) and 1 g/kg mannanoligosaccharide (75%), and basal diets plus synbiotics (1 g of probiotics B. subtilis product/kg of diets (4 × 10 cfu/kg), 150 mg/kg xylooligosaccharide (35%) and 1 g/kg mannanoligosaccharide (75%). The results demonstrated that on 21 and 42 days, dietary supplementation of the synbiotics significantly increased daily weight gain (p < 0.05), feed efficiency (p < 0.05), the villus height and villus:crypt ratio in the duodenum, jejunum and ileum (p < 0.05), as well as intestinal mucosa sIgA content (p < 0.05), serum T-SOD activity (p < 0.05) and lysozyme content (p < 0.05), comparing with control group. In conclusion, synbiotics (B. subtilis and xylooligosaccharide and mannanoligosaccharide) is one of the safe and ideal dietary supplementations to increase broilers' growth performance by improving small intestinal morphology, sIgA content and antioxidant capabilities.

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“…Synbiotics were effective in improving the growth of broiler in the diet of chickens (AbdelRaheem et al, 2012;Mookiah et al, 2014). Feeding of synbiotics in broiler chicken was found to have beneficial effect on intestinal morphology and nutrient absorption leading to enhanced performance (Awad et al, 2008;Hassanpour et al, 2013). Very few studies have reported the optimal benefits of synbiotics in poultry (Li et al, 2008).…”

Section: Synbioticsmentioning

confidence: 99%

Exploring alternatives to antibiotics as health promoting agents in poultry- a review

Yadav¹,

Kolluri²,

Gopi³

et al. 2016

JEBAS

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Poultry industry has undergone rapid growth during last three decades. For which even higher usage of antibiotics, both as growth promoters as well as therapeutic agents, has been adopted. However, due to the fear of resistance development in bacterial populations to antibiotics, presence of antibiotic residues in poultry products and increasing consumer demand for products free from antibiotic residues, search for alternatives that could replace antibiotics without causing loss to productivity or product quality has accelerated. Such alternatives in poultry include the use of organic acids, probiotic microorganisms, prebiotic substrates that benefit proliferation of beneficial bacterial populations or synbiotic (combinations of prebiotics and probiotics) ensuring better production and maintaining health of the birds. Others include vitamins and minerals, herbal drugs, plant extracts, phytobiotics and antimicrobial peptides. Probiotic organisms provides competition to pathogenic organisms for intestinal colonizing sites, reduce the diversion of nutrients for harmful microbes and the toxins produced by them and stimulates the immune systems. Similarly, prebiotic offers an alternative, as it alters the intestinal microbes and immune system to reduce colonization by pathogens and allows proliferation of beneficial microflora in the gut. Even using synbiotic is a better strategy for enhancing poultry production, however, more research is needed for selection of probiotic, prebiotics or synbiotics either alone or in combination that can result in the selection of strains capable of performing effectively in the gastrointestinal tract. The contents of this review will be useful for researchers to enrich their knowledge on alternatives of antibiotics in poultry birds without compromising performance of birds and bird welfare.

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Effects of synbiotic on the intestinal morphology and humoral immune response in broiler chickens

Cited by 51 publications

References 23 publications

Effect of Effective Microorganisms on intestinal morphology and morphometry in Japanese quails

Effect of Effective Microorganisms on intestinal morphology and morphometry in Japanese quails

Effects of dietary supplementation of synbiotics on growth performance, intestinal morphology, sIgA content and antioxidant capacities of broilers

Exploring alternatives to antibiotics as health promoting agents in poultry- a review

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