Effects of synbiotic food consumption on metabolic status of diabetic patients: A double-blind randomized cross-over controlled clinical trial

Asemi, Zatollah; Khorramirad, Ashraf; Alizadeh, Sabihe‐Alsadat; Shakeri, Hossein; Esmaillzadeh, Ahmad

doi:10.1016/j.clnu.2013.05.015

Cited by 168 publications

(137 citation statements)

References 24 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…The activities of glutathione dependent antioxidant enzymes, SOD, catalase, and MDA remained unchanged in dextrin or oligofructose groups. 9 Asemi and colleagues 32 reported that symbiotic food (lactobacillus + inulin for 6 weeks) consumption in diabetic patients led to a significant increase in plasma total GSH and serum uric acid levels. No significant change was observed in plasma TAC levels.…”

Section: Discussionmentioning

confidence: 99%

A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

et al. 2015

View full text Add to dashboard Cite

“…For TC and TG, when the study by Asemi et al [14] was excluded, the pooled standardized mean differences in the T2DM group changed from −0. [16] significantly affected the pooled effects in the subgroup of T2DM, in that the pooled standardized mean difference changed from −0.08 (95% CI −1.21, 1.04; p = 0.88) to 0.82 (95% 0.02, 1.62; p = 0.04) when the study was excluded.…”

Section: Effects Of Probiotics On Insulinmentioning

confidence: 99%

“…Several clinical trials have shown the effect of probiotics on the reduction of glucose, insulin, HbA 1c and other glycemic factors for type 2 diabetes mellitus (T2DM) [10][11][12][13][14][15][16][17][18][19] and other diabetes or metabolic syndrome (defined as MS) [9,[20][21][22][23][24][25][26]. However, their dosages, bacterial strains and time of therapy were short of homogeneity.…”

Section: Introductionmentioning

confidence: 99%

Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials

Wang

Juan

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Background: A systematic review and meta-analysis was designed to evaluate the effect of probiotics on diabetes and its associated risk factors. Methods: We systematically searched the Cochrane Library, PubMed, EMBASE and Web of Science to June 2016. We also hand-searched the citation lists of included studies and previously identified systematic reviews to identify further relevant trials. Our primary outcome variables included glucose, glycated hemoglobin (HbA 1c ) and insulin. The pooled standardized mean difference was used to compare the effect between the probiotics and controlled groups, and the pooled standardized mean difference effect size with a 95% confidence interval (CI) was estimated using a random-effect model. Heterogeneity was assessed with Cochran's Q and Higgins I 2 tests. Two reviewers assessed trial quality and extracted data independently. The analysis and bias for each included study was performed and assessed using Review Manager 5.2. Results: Eighteen randomized, placebo-controlled studies (n = 1056 participants, 527 consuming probiotics, 529 not consuming probiotics) were included for analysis. Comparing the probiotics groups with the control groups, there were statistically significant pooled standardized

show abstract

“…In addition, data on the effects of synbiotics and probiotics on metabolic status are conflicting. Administration of a synbiotic food containing Lactobacillus sporogenes (27 × 10 7 CFU) and 1.08 g inulin to diabetic patients for 6 weeks compared to the control food resulted in decreased serum insulin levels [19]. However, no significant effects on fasting plasma glucose (FPG), serum insulin levels, and homeostatic model assessment for insulin resistance (HOMA-IR) were seen following the consumption of probiotic supplements among patients with T2DM after 8 weeks [20].…”

Section: Introductionmentioning

confidence: 99%

Effects of Daily Consumption of Synbiotic Bread on Insulin Metabolism and Serum High-Sensitivity C-Reactive Protein among Diabetic Patients: A Double-Blind, Randomized, Controlled Clinical Trial

et al. 2014

Self Cite

View full text Add to dashboard Cite

Background: This study was conducted to evaluate the effects of daily consumption of synbiotic bread on the metabolic status of patients with type 2 diabetes mellitus. Methods: This randomized, double-blind, controlled clinical trial was performed in 81 diabetic patients. The subjects were randomly assigned to consumption of synbiotic (n = 27), probiotic (n = 27), or control bread (n = 27) for 8 weeks 3 times a day in a 40-gram package. The synbiotic bread contained Lactobacillus sporogenes (1 × 10⁸ CFU) and 0.07 g inulin per 1 g. The probiotic bread contained L. sporogenes (1 × 10⁸ CFU per 1 g). Fasting blood samples were taken at baseline and after an 8-week intervention for quantification of related factors. Results: Consumption of the synbiotic bread resulted in a significant reduction in serum insulin levels (-3.2 ± 5.4 vs. -0.3 ± 3.4 and 0.6 ± 4.7 µIU/ml, respectively, p = 0.007), homeostatic model assessment for insulin resistance scores (-1.5 ± 2.7 vs. -0.2 ± 1.6 and 0.4 ± 3.5, respectively, p = 0.03), and homeostatic model assessment-β-cell function (-7.2 ± 16.3 vs. -0.7 ± 10.8 and 0.7 ± 8.2, respectively, p = 0.04) compared to the probiotic and control breads. We did not find any significant effect of synbiotic bread consumption on fasting plasma glucose, the quantitative insulin sensitivity check index, or serum hs-CRP levels compared to other breads. Conclusion: Consumption of the synbiotic bread among diabetic patients had beneficial effects on insulin metabolism.

show abstract

Effects of synbiotic food consumption on metabolic status of diabetic patients: A double-blind randomized cross-over controlled clinical trial

Cited by 168 publications

References 24 publications

A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials

Effects of Daily Consumption of Synbiotic Bread on Insulin Metabolism and Serum High-Sensitivity C-Reactive Protein among Diabetic Patients: A Double-Blind, Randomized, Controlled Clinical Trial

Contact Info

Product

Resources

About