Effects of sustained isometric handgrip on praecordial accelerocardiogram in normal subjects and in patients with heart disease.

Hume, L.; Irving, John B.; Kitchin, A. H.; Reuben, S R

doi:10.1136/hrt.37.8.873

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…However, in their study, the patients’ cardiac autonomic function was not evaluated by means of HRV analysis 20. It is noteworthy that such maneuvers provide indices which represent powerful predictors of cardiovascular impairment and reliable diagnostic and prognostic markers 21–23…”

Section: Introductionmentioning

confidence: 99%

Is cardiac autonomic modulation during upper limb isometric contraction and Valsalva maneuver impaired in COPD patients?

Goulart¹,

Cabiddu²,

Schneiders³

et al. 2017

COPD

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PurposeTo evaluate the heart rate variability (HRV) indices and heart rate (HR) responses during isometric contraction (IC) and Valsalva maneuver (VM) in COPD patients.MethodsTwenty-two stable moderate to severe COPD patients were evaluated. R-R intervals were recorded (monitor Polar® S810i) during dominant upper limb IC (2 minutes). Stable signals were analyzed by Kubios HRV® software. Indices of HRV were computed in the time domain (mean HR; square root of the mean squared differences of successive RR intervals [RMSSD] and HRV triangular index [RR tri index]) and in the frequency domain (high frequency [HF]; low frequency [LF] and LF/HF ratio). The HR responses were evaluated at rest, at the peak and at the nadir of the VM (15 seconds). The Valsalva index was also calculated.ResultsDuring IC: time domain indices (mean HR increased [P=0.001], RMSSD, and RR tri index decreased [P=0.005 and P=0.005, respectively]); frequency domain indices (LF increased [P=0.033] and HF decreased [P=0.002]); associations were found between forced expiratory volume in 1 second (FEV1) vs RMSSD (P=0.04; r=−0.55), FEV1 vs HR (P=0.04; r=−0.48), forced vital capacity (FVC) vs RMSSD (P=0.05; r=−0.62), maximum inspiratory pressure (MIP) vs HF (P=0.02; r=0.68). FEV1 and FVC justified 30% of mean HR. During VM: HR increased (P=0.01); the nadir showed normal bradycardic response; the Valsalva index was =0.7.ConclusionCOPD patients responded properly to the upper limb IC and to the VM; however, HR recovery during VM was impaired in these patients. The severity of the disease and MIP were associated with increased parasympathetic modulation and higher chronotropic response.

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Section: Introductionmentioning

confidence: 99%

Is cardiac autonomic modulation during upper limb isometric contraction and Valsalva maneuver impaired in COPD patients?

Goulart¹,

Cabiddu²,

Schneiders³

et al. 2017

COPD

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“…It would seem unlikely that the results of studies from normal volunteers can be readily extrapolated to explain the behaviour of a heterogeneous group of hypertensive patients. Studies using isometric exercise as a stress test in the cardiac catheterization laboratory have demonstrated a wide range of responses of left ventricular filling pressure, contractility and cardiac output in patients with varying degrees of left ventricular dysfunction on other criteria (Helfant et al, 1971;Hume et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

“…Studies in healthy subjects have shown that sustained isometric exercise results in a highly significant rise in systemic blood pressure and heart rate (Lind, Taylor, Humphreys, Kennelly & Donald, 1964;Donald, Lind, McNicol, Humphreys, Taylor & Staunton, 1967;. In patients with left ventricular myocardial disease, sustained isometric handgrip exercise has been shown to evoke or accentuate haemodynamic evidence of cardiac dysfunction (Helfant, de Villa & Meister, 1971;Siegel, Gilbert, Nutter, Schlant & Hurst, 1972;Fisher, Nutter, Jacobs, & Schlant, 1973;Hume, Irving, Kitchin & Reuben, 1975).…”

Section: Introductionmentioning

confidence: 99%

The effects of alpha‐ and beta‐adrenergic receptor blockers on the pressure responses to isometric exercise in hypertensive patients.

Reuben¹,

Gale²,

Blake³

1979

Brit J Clinical Pharma

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1 The cardiovascular responses to handgrip exercise have been studied in ten patients with uncomplicated essential hypertension in a randomized crossover study of propranolol and prazosin. 2 Isometric handgrip exercise was performed with a calibrated strain gauge dynamometer at 30% of maximum voluntary contraction for 3 min. 3 Blood pressure and heart rate were measured in the supine position at rest and in the last 10 s of the exercise period. 4 These exercise studies were undertaken at the end of a run-in period and at the end of 1 month's optimal therapy with the two drugs. 5 The active treatment periods were separated by a 2 weeks placebo washout period. 6 Both drugs lowered the supine and standing systolic and diastolic pressures and there was no difference between these drugs in their effect on these variables. 7 Propranolol lowered the resting heart rate and neither drug suppressed the pressor response to isometric exercise. 8 The degree of pressure rise was similar with both drugs but propranolol suppressed isometric exercise-induced tachycardia.

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“…The praecordial accelerocardiogram transducer, which has been described in detail previously (Reuben and Littler, 1973;Hume et al, 1975), was attached by an adhesive disc to the chest wall overlying the fifth rib at a point medial to the apex beat. A simultaneous electrocardiogram was recorded with the accelerocardiogram on the second channel of an ultraviolet recorder.…”

mentioning

confidence: 99%

Non-invasive assessment of left ventricular response to Valsalva manoeuvre in normal and diabetic subjects using praecordial accelerocardiography.

Hume¹,

Ewing²,

Campbell³

et al. 1979

Heart

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SUMMARYThe left ventricular response to the Valsalva manoeuvre was studied in 5 normal subjects (group 1), 6 diabetics without autonomic neuropathy (group 2), and 5 diabetics with autonomic neuropathy (group 3), using the maximum amplitude of the praecordial accelerocardiogram (DE) as a noninvasive index of left ventricular performance.During the Valsalva manoeuvre DE decreased in all 3 groups. In groups 1 and 2, DE increased significantly above the control value after release of the manoeuvre (DE overshoot) but this did not occur in group 3. It is suggested that the overshoot of DE in groups 1 and 2 reflects an increase in left ventricular contractility after release of the Valsalva manoeuvre and the absence of an overshoot in DE in the patients with autonomic neuropathy is the result of loss of cardiac adrenergic innervation.The ability to detect an abnormal cardiovascular response to the Valsalva manoeuvre using the non-invasive technique of praecordial accelerocardiography may be of practical value in the assessment of left ventricular function.

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Effects of sustained isometric handgrip on praecordial accelerocardiogram in normal subjects and in patients with heart disease.

Cited by 5 publications

References 24 publications

Is cardiac autonomic modulation during upper limb isometric contraction and Valsalva maneuver impaired in COPD patients?

Is cardiac autonomic modulation during upper limb isometric contraction and Valsalva maneuver impaired in COPD patients?

The effects of alpha‐ and beta‐adrenergic receptor blockers on the pressure responses to isometric exercise in hypertensive patients.

Non-invasive assessment of left ventricular response to Valsalva manoeuvre in normal and diabetic subjects using praecordial accelerocardiography.

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