Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: a randomized double‐blind placebo‐controlled trial

Abstract

Previous studies have shown a beneficial effect of curcuminoids supplementation on serum concentrations of adipokines; however, there are no published studies that have examined this effect among critically ill patients. We aimed to assess the effects of supplementation with curcuminoids on serum concentrations of leptin and adiponectin in critically ill patients with traumatic brain injury (TBI). In this trial, 62 critically ill patients with TBI, aged 18-65 years, were randomly allocated to receive either 500 mg/day curcuminoids (co-administered with 5 mg/day piperine) or matched placebo for 7 days. Patients in both intervention groups received routine treatments for TBI as well as enteral nutrition. Serum concentrations of leptin and adiponectin were measured at baseline and at the end of trial. We found a significant reduction in serum levels of leptin in both curcuminoids (47.1%) and placebo (22.8%) groups; though the magnitude of reduction was greater in the former (p < .05). Supplementation with curcumioinds was not found to alter serum concentrations of adiponectin (p > .05). Supplementation with curcumioinds significantly reduced serum levels of leptin but had no significant effect on adiponectin levels in critically ill

Curcumin-Impregnated Drug Delivery Systems May Show Promise in the Treatment of Diseases Secondary to Traumatic Brain Injury: Systematic Review

“…Of the studies investigating TBI-related curcumin between 2005 and 2022, 42 were clinical trials. 30,31 The number of studies investigating curcumin in TBI through drug delivery system is three [32][33][34] (Table 1).…”

“…About 59,722 studies performed between 1891 and 2022 were retrieved using the keyword “traumatic brain injury.” Of the studies investigating TBI-related curcumin between 2005 and 2022, 42 were clinical trials. 30, 31 The number of studies investigating curcumin in TBI through drug delivery system is three 32–34 (Table 1).…”

“…Curcumin significantly reduces neuroinflammation and improves behavioral status by slightly increasing the levels of nuclear factor erythroid 2-related to factor 2 brain-derived neurotrophic factor. 50 Shadnoush et al 30 reported that curcuminoid supplementation has a beneficial effect on serum concentrations of adipokines, but this beneficial effect has not yet been studied in the treatment of critical TBI cases. Placebo-controlled 500 mg/day curcuminoids were administered to 62 critical cases with TBI aged 18 to 65 years.…”

“…There was a significant decrease in serum leptin levels in the curcuminoids group compared to the placebo group; however, despite supplementation with curcuminoids, serum concentrations of adiponectin in cases with TBI did not change. 30 Zahedi et al 31 reported that the effects of curcuminoid supplementation on inflammatory and oxidative stress biomarkers, clinical outcomes, and nutritional status in critically ill patients with TBI are unknown, although the beneficial effects of polyphenolic curcuminoids in the treatment of TBI have been proposed in experimental studies. In one such study, serum levels of interleukin-6, tumor necrosis factor-alpha, monocyte chemoattractant protein-1, and C-reactive protein were significantly decreased in patients treated with curcuminoid compared to the placebo group.…”

Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus

“…Human studies with repeated piperine administrations comprise only a small number of studies using piperine without concomitant administration of other substances (drug interaction studies with piperine-only run-in phases of 3–10 days and piperine doses of 15–20 mg/day) [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ]. In addition, there are a number of other studies in which piperine (in several cases in form of highly piperine-enriched pepper extracts) was given in combination with other substances, e.g., curcumin, resveratrol, Camellia sinensis extract, herbal extracts or others, in order to increase the bioavailability or effectiveness of these substances [ 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 ]. Some of these piperine combination studies included control groups receiving piperine without concomitant administration of the other substances mentioned above, but these s...…”