Effects of Supplemental D-Psicose on Glucose Tolerance and Serum Adipocytokine Levels in Rats Fed a High-Fat Diet or a Low-Fat Diet

Matsuo, Tatsuhiro; Izumori, Ken

doi:10.5650/jos.53.453

Cited by 13 publications

(10 citation statements)

References 33 publications

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“…Matsuo and Izumori (2004) proposed that d ‐psicose induced higher glycogen deposition and liver enlargement. Liver enlargement occurs in animals and humans under a variety of conditions and can be the result of a physiological adaptation to an enhanced workload or metabolic demand, a toxic effect, an inflammatory process, or a proliferative disease (Bar and others 1999).…”

Section: Resultsmentioning

confidence: 99%

“…It was also reported that supplemental d ‐psicose reduced body weight gain and abdominal fat mass in normal rat for 8 wk (Matsuo and Izumori 2006). However, d ‐psicose supplementation did not show significant lowering effect on weight gain and abdominal fat mass in rats fed high fat diet for 16 wk (Matsuo and Izumori 2004). It seems that these inconsistent results were due to different experimental design and diet.…”

Section: Introductionmentioning

confidence: 99%

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Dietary d‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats

Chung¹,

Lee²,

Kim³

et al. 2012

Journal of Food Science

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary d‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats

Chung¹,

Lee²,

Kim³

et al. 2012

Journal of Food Science

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“…D-Allulose is an epimer at the carbon 3 position of D-fructose ( Supplementary Fig. 1) and has antihyperlipidemic and antihyperglycemic effects that decrease adipose tissue mass in animals and humans, providing a potential use as a zerocalorie functional sweetener [4][5][6][7][8][9][10] . D-Allulose and D-allose, a C-3 epimer of D-glucose ( Supplementary Fig.…”

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confidence: 99%

The rare sugar d-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical

et al. 2020

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The rare sugar D-tagatose is a safe natural product used as a commercial food ingredient. Here, we show that D-tagatose controls a wide range of plant diseases and focus on downy mildews to analyze its mode of action. It likely acts directly on the pathogen, rather than as a plant defense activator. Synthesis of mannan and related products of D-mannose metabolism are essential for development of fungi and oomycetes; D-tagatose inhibits the first step of mannose metabolism, the phosphorylation of D-fructose to D-fructose 6-phosphate by fructokinase, and also produces D-tagatose 6-phosphate. D-Tagatose 6-phosphate sequentially inhibits phosphomannose isomerase, causing a reduction in D-glucose 6-phosphate and D-fructose 6-phosphate, common substrates for glycolysis, and in D-mannose 6-phosphate, needed to synthesize mannan and related products. These chain-inhibitory effects on metabolic steps are significant enough to block initial infection and structural development needed for reproduction such as conidiophore and conidiospore formation of downy mildew.

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“…13,14) We found that 5% D-psicose supplementation increased liver weight and glycogen content in rats as compared with a 5% cellulose supplementation. 8,15) Moreover, Murao et al found that D-psicose stimulated insulin secretion in a dose-dependent manner in INS-1 cells and that Dpsicose might have a different insulin stimulating mechanism from glucose. 16) The blood glucose level is regulated by glucose uptake in several peripheral tissues, mostly the liver and skeletal muscles.…”

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confidence: 99%

Effects of DietaryD-Psicose on Diurnal Variation in Plasma Glucose and Insulin Concentrations of Rats

Matsuo

Izumori

2006

Bioscience, Biotechnology, and Biochemistry

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The effects of supplemental D-psicose in the diet on diurnal variation in plasma glucose and insulin concentrations were investigated in rats. Forty-eight male Wistar rats were divided into four groups. Each group except for the control group was fed a diet of 5% Dfructose, D-psicose, or psico-rare sugar (3:1 mixture of D-fructose and D-psicose) for 8 weeks. Plasma glucose levels were lower and plasma insulin levels were higher at all times of day in the psicose and psico-rare sugar groups than in the control and fructose groups. Weight gain was significantly lower in the psicose group than in the control and fructose groups. Liver glycogen content, both before and after meals was higher in the psicose group than in the control and fructose groups. These results suggest that supplemental D-psicose can lower plasma glucose levels and reduce body fat accumulation. Hence, D-psicose might be useful in preventing postprandial hyperglycemia in diabetic patients.

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Effects of Supplemental D-Psicose on Glucose Tolerance and Serum Adipocytokine Levels in Rats Fed a High-Fat Diet or a Low-Fat Diet

Cited by 13 publications

References 33 publications

Dietary d‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats

Dietary d‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats

The rare sugar d-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical

Effects of DietaryD-Psicose on Diurnal Variation in Plasma Glucose and Insulin Concentrations of Rats

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