Effects of supercoiling on the sequence-specific photo-modification of DNA by a vanadium(V)-peroxo complex

Synthesis, structure, DNA binding and DNA cleavage activity of oxovanadium(IV) N-salicylidene-S-methyldithiocarbazate complexes of phenanthroline bases

“…Bleomycin vanadyl(IV) and [VO(phen)(H 2 O) 2 ] 2+ complexes are known to show chemical nuclease activity in the presence of H 2 O 2 [41,42]. There are few reports on oxovanadium(V) and peroxovanadium(V) complexes cleaving DNA on photo-activation in UV-A light [43][44][45][46]. Herein, we present the synthesis, structure, DNA binding and photo-induced DNA cleavage activity of oxovanadium(IV) complexes [VO(salmdtc)(B)] (1-3), where salmdtcH 2 is N-salicylidene-S-methyldithiocarbazone and B is N,N-donor heterocyclic base, viz.…”

Synthesis, Characterization, and DNA‐Binding and ‐Photocleavage Properties of Water‐Soluble Lanthanide Porphyrinate Complexes

“…The plasmid DNA (pBluescript) used in the DNA-unwinding and -photocleavage assays was extracted and purified from Escherichia coli JM/109 Bluescript according to a literature procedure that was detailed in our previous work. [60] Elemental analyses (C, H, N) were performed by the Shanxi University, P.R. China.…”

An unexpected oxovanadium(IV) complex with in situ generated lactone ligand: Synthesis, crystal structure and DNA-binding property

“…On the other hand, amino acid Schiff bases and their first-row transition metal complexes exhibit fungicidal, bactericidal, antiviral, and antitubercular activity [13][14][15][16][17]. Furthermore, oxovanadium complexes, especially with phenanthroline ligands, exhibit potent antitumor activity [18,19], DNA binding and DNA-photocleavage activities [20][21][22][23][24].…”

“…On the other hand, amino acid Schiff bases and their first-row transition metal complexes exhibit fungicidal, bactericidal, antiviral, and antitubercular activity [13][14][15][16][17]. Furthermore, oxovanadium complexes, especially with phenanthroline ligands, exhibit potent antitumor activity [18,19], DNA binding and DNA-photocleavage activities [20][21][22][23][24].In our previous work, we have synthesized and structurally characterized some oxovanadium complexes with multidentate Schiff base ligand and 1, 10-phenanthroline [25][26][27][28][29][30]. To continue our research in this project, we designed a new aminophenol-based multifunctional Schiff base ligand K 2 HL 1 (K 2 HL 1 = potassium 2-(((2-hydroxynaphthalen-1-yl)methylene)amino)pentanedioate) to construct potential oxovanadium-based material and drug.…”