2010
DOI: 10.1016/j.inoche.2010.06.040
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An unexpected oxovanadium(IV) complex with in situ generated lactone ligand: Synthesis, crystal structure and DNA-binding property

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Cited by 32 publications
(6 citation statements)
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(53 reference statements)
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“…Oxidovanadium complexes with N-donor heterocycle ligands show activity towards DNA cleavage upon near-IR irradiation [35][36][37]. In some cases, selective binding to cancer cell DNA is observed [37][38][39][40][41]. Thus, such complexes can be used in cancer photodynamic therapy.…”
Section: Introductionmentioning
confidence: 99%
“…Oxidovanadium complexes with N-donor heterocycle ligands show activity towards DNA cleavage upon near-IR irradiation [35][36][37]. In some cases, selective binding to cancer cell DNA is observed [37][38][39][40][41]. Thus, such complexes can be used in cancer photodynamic therapy.…”
Section: Introductionmentioning
confidence: 99%
“…113,241 The complexes in Figures 1.15 DNA in a partial/weak intercalative binding mode. 113,167,211,216,219 The DPPZ complexes in found to be groove binders. 21,167 Electrostatic attraction to DNA was also noted in some cases.…”
Section: Phen Dpq Dppzmentioning
confidence: 99%
“…Planar nitrogen-donor heterocyclic aromatic ligands such as 1,10-phenanthroline (PHEN), dipyrido[3,2-d:2',3'-f]quinoxaline (DPQ) and dipyrido[3,2-a:2',3'-c]phenazine (DPPZ) (Figure 1.13) enable vanadium (and indeed other metal) complexes to bind to DNA through intercalative or groove binding modes. 2,20,21,34,42,99,100,113,134,135,167,171,[182][183][184][211][212][213][214][215][216][217][218][219][220][221][222][223][224][225][226] It has been consistently shown that the inclusion of phenanthroline-derived ligands improves the DNA binding affinity of oxovanadium(IV) complexes. 227 Phenanthroline-type ligands also enhance the lipophilic character of the complexes, enabling the drug to enter lipophilic cellular membranes.…”
Section: Co-ligandsmentioning
confidence: 99%
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