“…However, gastrointestinal blood-loss would seem to make aspirin inappropriate for use in patients with chronic uraemia who are already anaemic (17). On the other hand, sulphinpyrazone is an effective antiplatelet agent which does not increase gastrointestinal blood-loss in normal subjects (5) and which has been shown to reduce clotting of Quinton-Scribner shunts (9). In experiments conducted in our unit, oral administration of sulphinpyrazone, in addition to heparin, reduced the deposition of fibrin within the dialyser and allowed a significant rise of plasma fibrinogen during haemodialysis, rather than the decrease observed when heparin alone was employed (31).…”