Effects of sulphinpyrazone and aspirin on gastrointestinal blood loss in man

Nutrition and platelet function in atherogenesis

“…They are released during platelet aggregation to a variety of agonists (Holmsen & Weiss, 1979). The most abundant protein is B-thromboglobulin (molecular weight 35000) and since it has a plasma half-life of 100 min (Dawes et al 1978) it is a useful indicator of enhanced in vivo platelet activation and release reaction.…”

Antiplatelet agents and extracorporeal circulation

“…However, gastrointestinal blood-loss would seem to make aspirin inappropriate for use in patients with chronic uraemia who are already anaemic (17). On the other hand, sulphinpyrazone is an effective antiplatelet agent which does not increase gastrointestinal blood-loss in normal subjects (5) and which has been shown to reduce clotting of Quinton-Scribner shunts (9). In experiments conducted in our unit, oral administration of sulphinpyrazone, in addition to heparin, reduced the deposition of fibrin within the dialyser and allowed a significant rise of plasma fibrinogen during haemodialysis, rather than the decrease observed when heparin alone was employed (31).…”