Antiplatelet agents and extracorporeal circulation

Mj, Weston; Hf, Woods; Jh, Turney

doi:10.1177/039139888000300302

Int J Artif Organs

1980

DOI: 10.1177/039139888000300302

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Antiplatelet agents and extracorporeal circulation

Weston Mj

Woods Hf

Turney Jh

Abstract: A controlled study on the value of oral supplementation with essential amino acids and keto analogues in chronic .hemodialysis. Proc. Clin. Dial. Transpl.

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1981

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Cited by 3 publications

References 21 publications

(17 reference statements)

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Albumin-IgG complexes in human serum and plasma that inhibit blood platelet adhesion.

Sharma¹,

Mohammad²,

Mason³

1981

Proc. Natl. Acad. Sci. U.S.A.

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Macromolecular albumin-IgG complexes have been isolated from human serum and characterized immunologically. These complexes are shown to be present in plasma also and appear to be normal constituents of blood., The complexes can be demonstrated in normal serum and plasma by immunoelectrophoresis and rocket immunoelectrophoresis, as well as by use of a two-step radioimmunologic binding test. The albumin-IgG complexes inhibit adhesion ofhuman platelets to glass and account for 12-16% of the total protein in serum.

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Albumin-IgG complexes in human serum and plasma that inhibit blood platelet adhesion.

Sharma¹,

Mohammad²,

Mason³

1981

Proc. Natl. Acad. Sci. U.S.A.

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Factor VIII complex in uraemia and effects of haemodialysis.

Turney¹,

Woods²,

Fewell³

et al. 1981

BMJ

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Levels of the factor VII complex were found to be raised in patients with chronic renal failure and further raised by regular dialysis. Increased fibrinogen concentrations were also found. These results suggest the existence of a prothrombotic state in uraemia that is exacerbated by haemodialysis. Ristocetin-induced platelet agglutination, however, was depressed in uraemia and worsened by dialysis. This defect may be transferred to normal platelets from dialysed uraemic plasma, suggesting the existence of an inhibitor of the interaction between factor VIII and platelet glycoprotein.These results may help to explain the anomaly of a prolonged bleeding time together with accelerated atherogenesis that is found in patients with uraemia receiving dialysis.

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Physiopathology and Management of Coagulation during Long-term Extracorporeal Respiratory Assistance

et al. 1990

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Thrombohemorrhagic risk is one of the main limiting factors in extracorporeal circulation. We describe here our experience in managing some life-threatening hematological complications in 58 patients with acute respiratory failure treated with long-term extracorporeal assistance. These patients were studied by clinical and laboratory means to assess questions related to heparin monitoring, coagulation complications and bleeding incidence. We found that two clotting tests, activated partial thromboplastin time (APTT) and activated clotting time (ACT) can be easily used to assess the safety of anticoagulant treatment (therapeutic ranges: APTT from 55 to 95 sec and ACT from 170 to 220 sec). A certain degree of coagulation activation, despite heparin, was indicated by the constant finding of thrombin-antithrombin complexes, while fibrinolytic activation, measured as plasminogen activator activity, was confined to the time of bypass connection and was of no clinical consequence. Platelet function was always impaired without relation to the platelet loss. Disseminated intravascular coagulation (DIC) (13 episodes) and severe bleeding (11 episodes) were major complications. DIC was corrected with a good outcome for 8 of 13 patients, while severe bleeding was correlated with a poor outcome in 8 of the 11 patients, probably because of the severity of the underlying disease.

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Antiplatelet agents and extracorporeal circulation

Abstract: A controlled study on the value of oral supplementation with essential amino acids and keto analogues in chronic .hemodialysis. Proc. Clin. Dial. Transpl.

Cited by 3 publications

References 21 publications

Albumin-IgG complexes in human serum and plasma that inhibit blood platelet adhesion.

Albumin-IgG complexes in human serum and plasma that inhibit blood platelet adhesion.

Factor VIII complex in uraemia and effects of haemodialysis.

Physiopathology and Management of Coagulation during Long-term Extracorporeal Respiratory Assistance

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