Effects of sulforaphane in the central nervous system

Huang, Chao; Wu, Jingjing; Chen, Dongjian; Jin, Jie; Wu, Yue; Chen, Zhuo

doi:10.1016/j.ejphar.2019.03.010

Cited by 54 publications

(35 citation statements)

References 191 publications

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“…Thus, Nrf2 pathway activation takes place to act against the accumulation of ROS. Consequently, Nrf2 activators have been proposed as antioxidant targets in neurodegenerative and neuropsychiatric disorders (Alzheimer's disease, Parkinson's disease, Huntington's disease, autism, schizophrenia, and depression) to counteract the increase in oxidative stress [138][139][140]. The action mechanisms of the antioxidants used against oxidative stress are shown in Figure 2.…”

Section: Antioxidant Treatment Against Oxidative Stress In Adhdmentioning

confidence: 99%

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

et al. 2020

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Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked with an increased risk of substance use and side effects. The pathophysiology of ADHD is not completely known, although it has been associated with an increase in inflammation and oxidative stress. This review presents an overview of findings following antioxidant treatment for ADHD and describes the potential amelioration of inflammation and oxidative stress using antioxidants that might have a future as multi-target adjuvant therapy in ADHD. The use of antioxidants against inflammation and oxidative conditions is an emerging field in the management of several neurodegenerative and neuropsychiatric disorders. Thus, antioxidants could be promising as an adjuvant ADHD therapy.

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Section: Antioxidant Treatment Against Oxidative Stress In Adhdmentioning

confidence: 99%

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

et al. 2020

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“…Interestingly, SFN has a unique ability in Nrf2 activation, which enhances the expression of heme oxygenase-1 (HO-1) and nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1 (NQO1) (59,67), thereby protecting neurons from 6-hydroxydopamine (6-OHDA), methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP) (68), amyloid β (Aβ) (69), and pro-inflammatory cytokines (70,71). Moreover, in Nrf2-deficient mice, SFN has no significant effect on the pro-inflammatory response, indicating SFN might be an Nrf2dependent anti-inflammatory agent (72,73). Therefore, we speculate that Nrf2 activation mediates the anti-oxidant stress and anti-inflammatory effects of SFN, thereby exerting SFN's neuroprotective effect (73).…”

Section: Sulforaphanementioning

confidence: 99%

Nrf2 Activators as Dietary Phytochemicals Against Oxidative Stress, Inflammation, and Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review

Yang

2020

Front. Psychiatry

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Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder with limited available treatments and diverse causes. In ASD patients, numerous researches demonstrated various alterations in inflammation/immune, oxidative stress, and mitochondrial dysfunction, and these alterations could be regulated by Nrf2. Hence, we aimed to systematically review the current evidence about the effects of Nrf2 activator supplementation on ASD objects from in vitro studies, animal studies, and clinical studies. Relevant articles were retrieved through searching for the Cochrane Library, PubMed, Web of Science, Scope, Embase, and CNKI databases (through September 23, 2020). Ultimately, we identified 22 preclinical studies, one cell culture study, and seven clinical studies, covering a total of five Nrf2 activators. For each Nrf2 activator, we focused on its definition, potential therapeutic mechanisms, latest research progress, research limitations, and future development directions. Our systematic review provided suggestive evidence that Nrf2 activators have a potentially beneficial role in improving autism-like behaviors and abnormal molecular alterations through oxidant stress, inflammation, and mitochondrial dysfunction. These dietary phytochemicals are considered to be relatively safer and effective for ASD treatment. However, there are few clinical studies to support the Nrf2 activators as dietary phytochemicals in ASD, even though several preclinical studies. Therefore, caution should be warranted in attempting to extrapolate their effects in human studies, and better design and more rigorous research are required before they can be determined as a therapeutic option.

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“…These results are promising to GLSs derivatives as a possible treatment to prevent MetS, however, there are few human trials. In addition, caution should be exercised since certain toxic effects have also been described ( 276 ). When other vegetable components with a high antioxidant capacity, like β-carotenes and vitamin E, have been administered as co-treatment or preventive agents for certain cancers, adverse effects have been found, reaching the point of having to stop the study because cancer progressed faster than among those that did not receive the supplement ( 283 , 284 ).…”

Section: Discussionmentioning

confidence: 99%

“…Jayakumar et al found that I3C and DIM treatment of HFD fed mice induces decreases in the levels of glucose, insulin, and glycated hemoglobin and ameliorated overall oxidative stress ( 275 ). It has recently been reported that SFN could prevent Alzheimer progression and cerebral ischemia ( 276 ). Thus, all these pieces of evidence highlight that the use of GLS derivatives from cruciferous vegetables might be considered for the treatment of MetS.…”

Section: Metabolic Syndrome: Definitionmentioning

confidence: 99%

Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome

Esteve

2020

Front. Nutr.

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An inverse correlation between vegetable consumption and the incidence of cancer has long been described. This protective effect is stronger when cruciferous vegetables are specifically consumed. The beneficial properties of vegetables are attributed to their bioactive components like fiber, antioxidants vitamins, antioxidants, minerals, and phenolic compounds. Cruciferous vegetables contain all these molecules; however, what makes them different are their sulfurous components, called glucosinolates, responsible for their special smell and taste. Glucosinolates are inactive biologically in the organism but are hydrolyzed by the enzyme myrosinase released as a result of chewing, leading to the formation of active derivatives such as isothiocyanates and indoles. A considerable number of in vitro and in vivo studies have reported that isothiocyanates and indoles elicit chemopreventive potency through multiple mechanisms that include modulation of phases I and II detoxification pathway enzymes, regulation of cell cycle arrest, and control of cell growth, induction of apoptosis, antioxidant activity, anti-angiogenic effects, and epigenetic regulation. Nuclear erythroid 2-related factor 2 (Nrf2) and Nuclear factor-κB (NF-κB) are key and central regulators in all these processes with a main role in oxidative stress and inflammation control. It has been described that isothiocyanates and indoles regulate their activity directly and indirectly. Today, the metabolic syndrome (central obesity, insulin resistance, hyperlipidemia, and hypertension) is responsible for a majority of deaths worldwide. All components of metabolic syndrome are characterized by chronic inflammation with deregulation of the PI3K/AKT/mTOR, MAPK/EKR/JNK, Nrf2, and NF-κB signaling pathways. The effects of GLSs derivatives controlling these pathways have been widely described in relation to cancer. Changes in food consumption patterns observed in the last decades to higher consumption of ultra-processed foods, with elevation in simple sugar and saturated fat contents and lower consumption of vegetables and fruits have been directly correlated with metabolic syndrome prevalence. In this review, it is summarized the knowledge regarding the mechanisms by which cruciferous glucosinolate derivatives (isothiocyanates and indoles) directly and indirectly regulate these pathways. However, the review places a special focus on the knowledge of the effects of glucosinolates derivatives in metabolic syndrome, since this has not been reviewed before.

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Effects of sulforaphane in the central nervous system

Cited by 54 publications

References 191 publications

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

Nrf2 Activators as Dietary Phytochemicals Against Oxidative Stress, Inflammation, and Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review

Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome

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