Effects of sulfasalazine on lipid peroxidation and histologic liver damage in a rat model of obstructive jaundice and obstructive jaundice with lipopolysaccharide-induced sepsis

Abstract

Sulfasalazine was associated with decreased neutrophil accumulation and lipid peroxidation in these rats with OJ. Administration of sulfasalazine before or after LPS-induced sepsis was associated with a reduction in lipid peroxidation and neutrophil accumulation; however, it did not attenuate histologic liver damage. There was no difference between the findings when sulfasalazine was administered before or after sepsis in OJ.

Effects of beta-glucan on hepatic damage caused by obstructive jaundice

“…[13][14][15][16][17] Bazı çalış-malarda TS'de karaciğerde ve uzak organlarda nötro-fil infiltrasyonunun olduğu, dolayısıyla MPO aktivitesinin arttığı gösterilmiştir. [2,18] Şener ve arkadaşları-nın [19] çalışmasında bası ülseri oluşturulan sıçanlarda, beta glukanın, MPO düzeyini düşürdüğü tespit edilmiştir. Babayiğit ve arkadaşlarının [20] çalışmasında da, karın sepsis modelinde, beta glukanın serumda MPO düzeyini azalttığı ve akciğer hasarını düzelttiği göste-rilmiştir.…”

“…[21] TS'de MDA düzeyinin arttığı çeşitli çalışmalarla ortaya konulmuştur. [18,[22][23][24][25][26] LPO'da benzer şekilde hücre-sel hasara işaret eder. Beta glukanın sepsis, yanık gibi durumlarda ortaya çıkan karaciğer hasarını ve MDA seviyesini azalttığını bildiren yayınlar vardır.…”

Effect of beta-glucan in lung damage secondary to experimental obstructive jaundice

“…MDA is an end product of lipid peroxidation and its increased level is an indicator of oxidative damage. MDA level increases in OJ (6,(24)(25)(26)(27)32). In a study conducted by fiener et al (14), in pulmonary damage resulting secondary to abdominal sepsis, beta-glucan reduced both MDA level and damage in the pulmonary tissue.…”

“…It has been reported that, in OJ, neutrophil infiltration is observed in the liver and distant internal organs, and thereby, that MPO activity is increased (5,32,34). In an experimental study conducted by fiener et al (35) in rats, in which pressure-induced ulcer was generated, it was determined that beta-glucan reduced the MPO level and organ damage.…”

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

“…However, in this study, 16 µM of PNE and PFNE exhibited inhibition of LP by 74.52% and 66.89% respectively. The oxidation/peroxidation of lipids by foreign chemicals is a major cause of liver injury [22]. In this in vitro test, the dose-response relationship and the significant (p < 0.05) inhibition of LP suggests PYT has potent antioxidant capacity.…”