Effect of beta-glucan in lung damage secondary to experimental obstructive jaundice

Erkol, Hayri; Kahramansoy, Nurettin; Kordon, Özgür; Büyükaşık, Oktay; Serin, Erdinç; Kükner, Aysel

doi:10.4318/tjg.2012.0396

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…MPO values decreasing but not with a significant difference may be due to the rats' count of group numerically. Erkol et al's study-on beta glucan as both prophylactic and therapeutic and it was found that beta glucan administration in the postoperative group decreased MPO, while in the prophylactic group did not provide a significant reduction for MPO [24]. MPO values not significantly decreasing may be the result of the administration of beta glucan prophylactically in our study.…”

Section: Discussionsupporting

confidence: 40%

Beta Glukanin Deneysel Böbrek İskemi Reperfüzyon Hasarina Karşi Koruyucu Etkileri

et al. 2022

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Amaç: Bu çalışma, böbrek dokusunda iskemi ve reperfüzyon hasarının neden olduğu oksidatif strese karşı beta glukanın olası koruyucu etkilerini araştırmayı amaçlamaktadır. Materyal ve metod: Çalışmada 300-350 gr ağırlığında 30 adet erkek Wistar albino sıçan kullanıldı (n=10). Sıçanlar rastgele Sham kontrol, iskemi reperfüzyon grubu (İR), iskemi reperfüzyon + beta glukan grubu (IR + BG) olmak üzere üç gruba ayrıldı. Sham grubuna sol nefrektomi yapıldı, sağ böbrek histopatolojik ve biyokimyasal inceleme için alındı. İR grubunda sol nefrektomi sonrası travmatik olmayan mikrovasküler klemp ile 45 dakika iskemi prosedürü uygulandı, ardından sağ böbrekte 60 dakika reperfüzyon uygulandı. IR+BG grubunda, sıçanlara 10 gün süreyle 100 mg/kg beta glukan gastrik gavaj yoluyla uygulandı. Anestezi altında sağ böbreğe 45 dakikalık iskemi sonrası 60 dakika reperfüzyon uygulandı. Bulgular: Biyokimyasal inceleme sonucunda MDA değerleri IR grubunda Sham grubuna göre anlamlı artış gösterdi (p<0,05). IR+BG grubunda IR grubuna göre anlamlı azalma oldu (p<0,05). IR grubunda doku MPO değerlerinde Sham grubuna göre anlamlı bir artış görülürken, IR+BG grubunda anlamlı bir azalma olmadı. Ayrıca doku katalaz seviyelerinde de anlamlı bir fark yoktu. Doku GSH değerleri IR grubunda Sham grubuna göre anlamlı düşüş gösterdi (p<0,05). IR+BG grubunda IR grubuna göre anlamlı artış bulundu (p<0,05). Histopatolojik incelemede IR+BG grubunda IR grubuna göre daha az hasar saptandı. Sonuç: Tüm bu veriler, beta glukanın renal iskemi reperfüzyon hasarı üzerinde antioksidan etkiye sahip olabileceğini göstermektedir.

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Section: Discussionsupporting

confidence: 40%

Beta Glukanin Deneysel Böbrek İskemi Reperfüzyon Hasarina Karşi Koruyucu Etkileri

et al. 2022

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“…β-Glucans are potent immunostimulants of both natural and adaptive immunity. Several experimental studies have reported antibacterial, antifungal, antiviral, and antioxidant activities of β-glucans (14,(16)(17)(18)(19). Babayigit et al (20) reported that β-glucan is effective in decreasing leukocyte infiltration in lung damage and improving survival.…”

Section: Discussionmentioning

confidence: 99%

“…Massive accumulation of neutrophils, interstitial pulmonary edema, and increased expression of proinflammatory mediators are the major characteristics of acute pulmonary injury (13). Neutrophil adhesion plays an important role in the development of chronic pulmonary inflammation (14,15). In LPS-induced endotoxemia, enhanced immune response is accomplished by an increased production of the proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of β-glucan on acute lung injury induced bylipopolysaccharide in rats

Iraz¹,

Eşrefoğlu²,

Aydın³

2015

Turk J Med Sci

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Background/aim: Lipopolysaccharide (LPS)-induced endotoxemia can cause serious organ damage such as acute lung injury and death by triggering the secretion of proinflammatory cytokines and acute-phase reactants. The goal of this study was to evaluate the effects of β-glucan on inflammatory mediator levels and histopathological changes in LPS-induced endotoxemia. Materials and methods:Forty-seven male Wistar albino rats were randomly allocated into four groups as follows: control group, LPS group (10 mg/kg LPS), LPS + β-glucan group (100 mg/kg β-glucan before LPS administration), and β-glucan group. Twelve hours after LPS administration, lung and serum samples were collected. Concentrations of IL-6, IL-8, C-reactive protein (CRP), and procalcitonin were measured in the serum at hours 0 (basal) and 12. The severity of lung damage was assessed by an appropriate histopathological scoring system. Results: Serum levels of CRP in the LPS group at 12 h were significantly higher than in the other groups, whereas serum IL-6 levels in the LPS and LPS + β-glucan groups at 12 h were significantly decreased. The mean histopathological damage score of the LPS group was slightly higher than that of the LPS + β-glucan group. Moreover, mortality rate was significantly decreased in the LPS + β-glucan group versus the LPS group.Conclusion: β-Glucan reduces endotoxemia-induced mortality and might be protective against endotoxemia-induced lung damage.

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“…If these conditions persist, acute respiratory distress syndrome may develop [ 17 ]. Furthermore, in experimental rat models with common bile duct ligation, it histologically demonstrated bronchiolar fluid accumulation and peribronchiolar neutrophil infiltration [ 8 ]. We did not perform lung biopsy in the present study, because this study was conducted in client-owned dogs.…”

Section: Discussionmentioning

confidence: 99%

Arterial blood gas anomaly in canine hepatobiliary disease

Kaneko

Torisu

Kobayashi³

et al. 2015

The Journal of Veterinary Medical Science

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Arterial blood gas analysis is an important diagnostic and monitoring tool for respiratory abnormalities. In human medicine, lung complications often occur as a result of liver disease. Although pulmonary complications of liver disease have not been reported in dogs, we have frequently encountered hypoxemia in dogs with liver disorders, especially extrahepatic biliary obstruction. In addition, respiratory disorders account for 20% of perioperative fatalities in dogs. Therefore, in this study, we evaluated the respiratory status in dogs with hepatobiliary disease by arterial blood gas analysis. PaO2 and PaCO2 were measured. Alveolar-arterial oxygen difference (AaDO2), the indicator of gas exchange efficiency, was calculated. Compared to healthy dogs (control group), hepatobiliary disease dogs had significantly lower PaO2 and higher AaDO2. Hypoxemia (PaO2 of ≤80 mmHg) was observed in 28/71 dogs with hepatobiliary disease. AaDO2 was higher (≥30 mmHg) than the control group range (11.6 to 26.4 mmHg) in 32/71 hepatobiliary disease dogs. By classifying type of hepatobiliary disease, dogs with extrahepatic biliary obstruction and chronic hepatitis showed significantly lower PaO2 and higher AaDO2 than in a control group. Dogs with chronic hepatitis also had significantly lower PaCO2. The present study shows that dogs with hepatobiliary disease have respiratory abnormalities more than healthy dogs. Preanesthetic or routine arterial blood gas analysis is likely beneficial to detect the respiratory abnormalities in dogs with hepatobiliary disease, especially extrahepatic biliary obstruction and chronic hepatitis.

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Effect of beta-glucan in lung damage secondary to experimental obstructive jaundice

Cited by 6 publications

References 29 publications

Beta Glukanin Deneysel Böbrek İskemi Reperfüzyon Hasarina Karşi Koruyucu Etkileri

Beta Glukanin Deneysel Böbrek İskemi Reperfüzyon Hasarina Karşi Koruyucu Etkileri

Protective effect of β-glucan on acute lung injury induced bylipopolysaccharide in rats

Arterial blood gas anomaly in canine hepatobiliary disease

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