Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films

Kelemen, András; Katona, Bálint; Módra, Szilvia; Aigner, Zoltán; Sebe, István; Pintye‐Hódi, Klára; Zelkó, Romána; Regdon, Géza; Kristó, Katalin

doi:10.3390/molecules25225248

Cited by 10 publications

(9 citation statements)

References 35 publications

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“…Different types of release exhibited by the buccal patch and important highlights are characterized in Table 2 . The contact angle measurement was suggested as a useful and rapid screening technique to identify potential mucoadhesive capacity of buccal formulation [ 82 ]. The buccal patch was fabricated from silica elastomer and various concentrations of carbopol 934P.…”

Section: Buccal Patchmentioning

confidence: 99%

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

et al. 2021

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Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery, anatomical and physiological aspects of oral mucosa, and various in vitro techniques frequently used for examining buccal drug-delivery systems. The role of mucoadhesive polymers, penetration enhancers, and enzyme inhibitors to circumvent the formulation challenges particularly due to salivary renovation cycle, masticatory effect, and limited absorption area are summarized. Biocompatible mucoadhesive films and patches are favored dosage forms for buccal administration because of flexibility, comfort, lightness, acceptability, capacity to withstand mechanical stress, and customized size. Preparation methods, scale-up process and manufacturing of buccal films are briefed. Ongoing and completed clinical trials of buccal film formulations designed for systemic delivery are tabulated. Polymeric or lipid nanocarriers incorporated in buccal film to resolve potential formulation and drug-delivery issues are reviewed. Vaccine-enabled buccal films have the potential ability to produce both antibodies mediated and cell mediated immunity. Advent of novel 3D printing technologies with built-in flexibility would allow multiple drug combinations as well as compartmentalization to separate incompatible drugs. Exploring new functional excipients with potential capacity for permeation enhancement of particularly large-molecular-weight hydrophilic drugs and unstable proteins, oligonucleotides are the need of the hour for rapid advancement in the exciting field of buccal drug delivery.

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Section: Buccal Patchmentioning

confidence: 99%

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

et al. 2021

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“…Polymers can be from natural sources, semi-synthetic, and synthetic. The most commonly used polymers are cellulose derivatives such as hydroxypropyl cellulose (HPC), hydroxypropyl-methylcellulose (HPMC), but chitosan, sodium alginate (SA), polyacrylic acid (PAA) and polyethylene glycol (PEG) are also common [ 12 , 13 , 14 , 15 , 16 ]. Plasticizers are also important additives in the formulation.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy

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et al. 2022

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“…In our previous work, the film-forming properties of HPMC were studied [ 18 ]. HPMC is a popular, water-soluble, semisynthetic polymer.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

et al. 2021

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Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, and polymer films, are among these possible products. Oral mucoadhesive systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused on formulating buccal mucoadhesive polymer films and investigating the physical and physical–chemical properties of films. Sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) were used as film-forming agents, glycerol (GLY) was added as a plasticizer, and cetirizine dihydrochloride (CTZ) was used as an active pharmaceutical ingredient (API). The polymer films were prepared at room temperature with the solvent casting method by mixed two-level and three-level factorial designs. The thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, and Raman spectra, as well as the dissolution of the prepared films, were investigated. The investigations showed that GLY can reduce the mucoadhesivity of films, and CTZ can increase the tensile strength of films. The distribution of CTZ proved to be homogeneous in the films. The API could dissolve completely from all the films. We can conclude that polymer films with 1% and 3% GLY concentrations are appropriate to be formulated for application on the buccal mucosa as a drug delivery system.

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Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films

Cited by 10 publications

References 35 publications

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

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