Effects of substance p on the spontaneous binding of <i>salmonella minnesota</i> r345 (rb) to human peripheral blood lymphocytes

Simone, Claudio De; Misefari, A.; Antonaci, Salvatore; Maffione, Angela Bruna; Jirillo, Emilio; Covelli, Venusia

doi:10.1002/jcla.1860030606

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Findings documented on capsaicin reveals long-term inhibitory effects on sensory neurons, which involve the release of neuropeptides such as substance P ( Holzer, 1990 ). De Simon et al. (1989) stated that this chemical is found in the brain and intestinal tissues, capable of modulating inflammation and immune response of host.…”

Section: Discussionmentioning

confidence: 99%

Performance and blood biochemistry profile of broiler chickens fed dietary turmeric (Curcuma longa) powder and cayenne pepper (Capsicum frutescens) powders as antioxidants

Adegoke

Abimbola

Sanwo

et al. 2018

Veterinary and Animal Science

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A 56-day experimental trial was conducted to investigate the performance and blood biochemistry profile of broiler chickens fed dietary turmeric ( Curcuma longa ) powder (t) and cayenne pepper ( Capsicum frutescens ) powder (c) as antioxidants. Two hundred and forty three (two-week old) broiler chicks were randomly allotted into nine treatment groups consisting of 27 selected chicks and three replicates of nine birds each. Three levels of t – (0, 200 and 400 g/ 100 kg basal diet) and three levels of c – (0, 100 and 200 g/ 100 kg basal diet) were used to formulate nine dietary treatments (basal diet (B) inclusive) and fed to each groupin two phases, starter (3–4 weeks) and finisher (5–8 weeks) phases in a randomized design. Feed intake and weight gain were highest ( p < 0.05) in chicks fed B + 100c diet at the starter phase, while feed conversion ratio was best ( p < 0.05) in chickens fed B + 400t + 200c diet at finisher phase. All chickens fed dietary additives had significantly ( p < 0.05) decreased serum alanine aminotransferase and low density lipoproteins but increased high density lipoproteins in the starter phase. The hematological count determined indicate poor ( p < 0.05) profile in groups fed B + 200c diet. Feeding broiler chicks dietary B + 400t + 200c was recommended for optimal growth performance. However, indices measured in the finisher phase allude that the best ( p < 0.05) lipid profile were for chickens allotted B + 400t and B + 200t + 100c diets, while chicks fed B + 200t + 100c diet had overall a better serum count in the finisher phase.

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Section: Discussionmentioning

confidence: 99%

Performance and blood biochemistry profile of broiler chickens fed dietary turmeric (Curcuma longa) powder and cayenne pepper (Capsicum frutescens) powders as antioxidants

Adegoke

Abimbola

Sanwo

et al. 2018

Veterinary and Animal Science

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“…Studies in animal models indicate that SP participates in the pathophysiology of Salmonella infection. Thus, SP exposure to a strain of Salmonella inhibited binding to lymphocytes, with a more pronounced effect on the T‐suppressor/cytotoxic T‐cell subset 59 . Oral intake of Salmonella in mice promptly results in substantial NK‐1R upregulation in the Peyer's patches and mesenteric lymph nodes 60 .…”

Section: Role Of Sp and Nk‐1r In Immune Responses During Salmonella Imentioning

confidence: 98%

Immunomodulatory Properties of Substance P

Koon

Pothoulakis

2006

Annals of the New York Academy of Sciences

123

112

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Communication between nerves and immune and inflammatory cells of the small and large intestine plays a major role in the modulation of several intestinal functions, including intestinal motility, ion transport, and mucosal permeability. Neuroimmune interactions at intestinal sites have been associated with the pathophysiology of infectious and enterotoxin-mediated diarrhea and intestinal inflammation, including inflammatory bowel disease (IBD). During the past 20 years the neuropeptide substance P (SP) has been identified as an important mediator in the development and progress of intestinal inflammation by binding to its high-affinity neurokinin-1 receptor (NK-1R). This peptide, released from enteric nerves, sensory neurons, and inflammatory cells of the lamina propria during intestinal inflammation, participates in gut inflammation by interacting, directly or indirectly, with NK-1R expressed on nerves, epithelial cells, and immune and inflammatory cells, such as mast cells, macrophages, and T cells. SP-dependent activation of these cells leads to the release of cytokines and chemokines as well as other neuropeptides that modulate diarrhea, inflammation, and motility associated with the pathophysiology of several intestinal disease states. The recent development of specific nonpeptide NK-1R antagonists and NK-1R-deficient mice helped us understand the functional importance of the SP-NK-1R system in mediating intestinal neuroimmune interactions and to identify the particular cells and signaling pathways involved in this response. This review summarizes our understanding on the immunomodulatory properties of SP and its receptor in the intestinal tract with particular focus on their involvement in intestinal physiology as well as in the pathophysiology of several intestinal disease states at the in vivo and cell signaling level.

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The orchestra of human bacteriome by hormones

Luqman

2023

Microbial Pathogenesis

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Effects of substance p on the spontaneous binding of salmonella minnesota r345 (rb) to human peripheral blood lymphocytes

Cited by 6 publications

References 19 publications

Performance and blood biochemistry profile of broiler chickens fed dietary turmeric (Curcuma longa) powder and cayenne pepper (Capsicum frutescens) powders as antioxidants

Performance and blood biochemistry profile of broiler chickens fed dietary turmeric (Curcuma longa) powder and cayenne pepper (Capsicum frutescens) powders as antioxidants

Immunomodulatory Properties of Substance P

The orchestra of human bacteriome by hormones

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