Effects of Subchronic Aluminum Exposure on Serum Concentrations of Iron and Iron-Associated Proteins in Rats

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Aluminum (Al) is the most abundant metal in the earth's crust. Al accumulates in erythrocyte and causes toxicity on erythrocyte membrane. The dysfunction of erythrocyte membrane is a potential risk to hypertension. The high Al content in plasma was associated with hypertension. To investigate the effect of AlCl3 on blood pressure and the function of erythrocyte membrane, the rats were intragastrically exposed to 0, 64(1/20 LD50), 128(1/10 LD50), and 256(1/5 LD50) mg/kg body weight AlCl3 in double distilled water for 120 days, respectively. Then, we determined the systolic and mean arterial blood pressures of rats, the osmotic fragility, the percentage of membrane proteins, the activities of Na(+)/K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-pX), and malondialdehyde (MDA) content of the erythrocyte membrane in this experiment. The results showed that AlCl3 elevated the systolic and mean arterial blood pressure of rats, increased the osmotic fragility, decreased the percentage of membrane protein, inhibited the activities of Na(+)/K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, CAT, SOD and GSH-pX, and increased the MDA content of erythrocyte membrane. These results indicate that AlCl3 may induce hypertension by disturbing the function of erythrocyte membrane.

Section: Introductionmentioning

confidence: 99%

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Zhang

Cao

Sun

et al. 2015

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“…It has been suggested that Al is a systemic toxicant [4], and our previous researches have demonstrated that Al has adverse effects on the brain [5], bone [6], immune function [7], and hematopoietic system [8]. For now, several studies showed the toxic effects of Al on the reproductive system of male animals [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aluminum Exposure on Serum Sex Hormones and Androgen Receptor Expression in Male Rats

Sun

et al. 2011

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The effects of aluminum (Al) exposure on reproductive functions of male rats were investigated. Forty male Wistar rats (4 weeks old) weighing 75-95 g were randomly divided into four groups and orally exposed to 0 (control group GC), 64.18 (low-dose group GL), 128.36 (middle-dose group GM), and 256.72 (high-dose group GH) mg/kg aluminum trichloride in drinking water for 120 days. The levels of testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were determined by radioimmunoassay. The androgen receptor (AR) expressions in testes were detected respectively by immunohistochemistry and time quantitative PCR. Results showed that the levels of T and LH in GM and GH were lower than those in GC (P< 0.05), but there were no significant changes in FSH level in all Al-treated groups (P > 0.05). AR protein expressions in GM and GH were lower than those in GC (P < 0.05), and there was a dose-response relationship between Al-exposure doses and AR protein expressions. The levels of AR mRNA expressions were lower in all Al-treated groups than those of GC (P < 0.05). The results indicate that Al can cause endocrinal disorders and interfere with AR expression, which suppresses development and functional maintenance of the testes.

“…Decreased erythrocytes number following Al exposure was observed in rats in our previous research [10]. Decreased erythrocytes number should lead to decreased immune function of erythrocytes following Al exposure, as E-CR1 existed on the erythrocytes membrane.…”

Section: Discussionmentioning

confidence: 61%

“…You et al [6] showed that immune function of erythrocytes in older dementia senilis mice was inhibited by AlCl 3 of 100 mg/kg body weight in drinking water. In our previous research the number of erythrocytes in rats was also reduced by AlCl 3 at dose of 67-100 mg/kg body weight per day in drinking water [10]. This experiment was used to offer a service to those people at a risk of oral exposure of different doses of Al.…”

Section: Discussionmentioning

confidence: 98%

Effects of Subchronic Aluminum Exposure on the Immune Function of Erythrocytes in Rats

Zhu

Zhao

et al. 2011

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This study assessed effects of aluminum (Al) exposure on the immune function of erythrocytes in rats. Forty male Wistar rats (5 weeks old) weighed 110-120 g were randomly allocated equally into four groups according to their weights and were orally exposed to 0, 64.18, 128.36, and 256.72 mg/kg body weight aluminum trichloride in drinking water for 120 days. Levels of erythrocytes C(3b) receptor rate (RBC-C(3b)RR), erythrocytes C(3b) immune complex rosette rate (RBC-ICR), erythrocytes rosette forming enhancing rate (ERER) and erythrocytes rosette forming inhibitory rate (ERIR) were determined by the end of experiment. The three Al-treated groups had lower values of RBC-C(3b)RR and ERER, and higher values of RBC-ICR and ERIR than those in control group. The levels of RBC-C(3b)RR and ERER decreased, while the levels of RBC-ICR and ERIR increased with the increases of Al content in drinking water. The results suggest that the immune function of erythrocytes in rats is suppressed by Al exposure.