Effects of sub-chronic exposure to terbutryn in common carp (Cyprinus carpio L.)

Velíšek, Josef; Sudová, Eliška; Máchová, Jana; Svobodová, Zdeňka

doi:10.1016/j.ecoenv.2009.10.005

Cited by 43 publications

(18 citation statements)

References 46 publications

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“…Generally, triazine pesticides have a direct effect on kidney structure and function in freshwater fish [10, 11, 36–38]. No histopathological changes were demonstrated in gills and liver following exposure to terbuthylazine-2-hydroxy.…”

Section: Resultsmentioning

confidence: 99%

Effect of Terbuthylazine-2-hydroxy at Environmental Concentrations on Early Life Stages of Common Carp (Cyprinus carpioL.)

Velíšek

Stará

Koutnik

et al. 2014

BioMed Research International

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The aim of the study was to investigate effects of the triazine's herbicide terbuthylazine-2-hydroxy on early life stage of common carp (Cyprinus carpio L.) through antioxidant indices, mortality, growth, development, and histopathology. Based on accumulated mortality in the experimental groups, lethal concentrations of terbuthylazine-2-hydroxy were estimated at 35-day LC50 = 10.9 mg/L terbuthylazine-2-hydroxy. By day 15, fish were exposed to 3.5 mg/L and by day 26, fish were exposed to 0.0029 mg/L; real environmental concentration in Czech rivers, 0.07 mg/L, 1.4 mg/L, and 3.5 mg/L terbuthylazine-2-hydroxy, showed significantly lower mass and total length compared with controls. Based on inhibition of growth in the experimental groups, lowest observed effect concentration (LOEC) = 0.002 mg/L terbuthylazine-2-hydroxy and no observed effect concentration (NOEC) = 0.0001 mg/L terbuthylazine-2-hydroxy. No significant negative effects on hatching or embryo viability were demonstrated at the concentrations tested, but significant differences in early ontogeny among groups were noted. Fish from the two highest tested concentrations showed a dose-related delay in development compared with the controls. Total superoxide dismutase (SOD) activity was significant lower in all groups testedly for terbuthylazine-2-hydroxy compared with the control group. At concentrations of 1.4 and 3.5 mg/L damage to caudal kidney tubules when compared to control fish was found.

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Section: Resultsmentioning

confidence: 99%

Effect of Terbuthylazine-2-hydroxy at Environmental Concentrations on Early Life Stages of Common Carp (Cyprinus carpioL.)

Velíšek

Stará

Koutnik

et al. 2014

BioMed Research International

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“…Velisek et al [29] reported changes in the histology of the liver (diffused steatosis with the loss of cellular shape and the presence of lipid inclusions in hepatic cells) and caudal kidney (destruction of renal tubules) in common carp after 28-day exposure to 40 μ g L −1 of terbutryn. Arufe et al [30] detected pathological changes in the livers of yolk sac larvae of gilthead seabream ( Sparus aurata ) after 72 hours exposure to a commercial formulation containing simazine (4.5 mg L −1 ).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Subchronic Exposure to Metribuzin onDanio rerio

Plhalová

Štěpánová

Prášková

et al. 2012

The Scientific World Journal

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The aim of this study was to assess the impact of metribuzin in surface waters on fish under experimental conditions. The effects of subchronic exposure to metribuzin on fish growth and the development of histopathological changes in selected organs (gill, kidney, liver) and on activity of some biochemical markers (CYP450, EROD) in Danio rerio were investigated during a 28-day toxicity test. Juvenile growth tests were performed on D. rerio according to OECD method number 215. Fish at an initial age of 30 days were exposed to a range of metribuzin concentrations (1.5, 5, 16, 33, and 53 mg L−1). Exposure to metribuzin at 53 mg L−1 was associated with increased mortality. Negative effects with regard to total body weight, length, and the inhibition of specific growth rate were induced at concentrations of 33 and 53 mg L−1. Histopathological examination revealed pathological lesions in the liver in pesticide-exposed fish only at the highest concentration of 53 mg L−1 of metribuzin. Based on the results of growth rate, biochemical markers (CYP450, EROD), and histopathological examination, the lowest observed effect concentration (LOEC) value was 33 mg L−1 and the no observed effect concentration (NOEC) value was 16 mg L−1.

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“…Nevertheless, a subtle effect of terbutryn on larval metabolism or behaviour cannot be completely excluded. For in stance for fishes, which are more sensitive to terbutryn, Velisek et al (2010) found sublethal effects in the form of different histological and biochemical endpoints starting at 4 µg l −1 . Few data are available for invertebrates regarding sublethal effects of terbutryn, but Streit & Peter (1978) reported effects of the related 2-chloro triazine herbicide, atrazine, at levels of 2% of the LC 50 after 1 mo of chronic exposure.…”

Section: Discussionmentioning

confidence: 99%

Herbicide indirectly reduces physiological condition of a benthic grazer

Rybicki¹,

Winkelmann²,

Hellmann³

et al. 2012

Aquat. Biol.

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Freshwater ecosystems are polluted with various environmental chemicals. For example, pesticides enter the aquatic environment via spray drift or surface runoff from catchment areas used for industrialised agriculture. In the present study, we investigated the response of the grazer−aufwuchs interaction when exposed to the herbicide terbutryn in a microcosm experiment. Terbutryn induced a trophic cascade with negative effects on grazers by inhibiting growth of primary producers. We determined a no-observed-effect concentration (measured as particulate organic carbon, NOEC POC ) of 0.21 µg l −1 for aufwuchs biomass and a lowest-observed-effect concentration (LOEC POC ) of 2.01 µg l −1. Furthermore, a shift in the aufwuchs community was detected in all terbutryn treatments nearly 4 wk after exposure, and this shift persisted until the end of the experiment in the treatment with the highest terbutryn concentration. In addition, reduced energy stores (triglycerides, TG) of the grazer Rhithrogena semicolorata (Heptageniidae: Ephemeroptera) were found (NOEC TG = 0.03 µg l ), which was interpreted as an indication of moderate starvation during the experiment. While starvation did not result in reduced larval growth as might have been expected, the ob served reduction of TG content in larvae (24%) is consistent with results from a separate experiment in which starvation alone induced a 15% reduction of TG content as well as reduced emergence, reduced size at emergence, and reduced egg production.

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Effects of sub-chronic exposure to terbutryn in common carp (Cyprinus carpio L.)

Cited by 43 publications

References 46 publications

Effect of Terbuthylazine-2-hydroxy at Environmental Concentrations on Early Life Stages of Common Carp (Cyprinus carpioL.)

Effect of Terbuthylazine-2-hydroxy at Environmental Concentrations on Early Life Stages of Common Carp (Cyprinus carpioL.)

The Effects of Subchronic Exposure to Metribuzin onDanio rerio

Herbicide indirectly reduces physiological condition of a benthic grazer

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